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H-Invitational ID: HIT000261638 Accession number: BC064930 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: ATP-binding cassette sub-family B member 10, mitochondrial; ATP-binding cassette transporter 10; ABC transporter 10 protein; Mitochondrial ATP-binding cassette 2; M-ABC2; Precursor;
 
 

Transcript original information
Accession number BC064930.1
CAGE tag ID NA
EST ID NA
Clone Number MGC:70707 IMAGE:6143235
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (ABCB10) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (ABCB10);
Sequence data provider NA
Annotation project NA
Length of cDNA 3621[bp] (No. of exon:13)[A:941 T:1008 G:885 C:787]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type Eye, retinoblastoma
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA Site: 3591(+) Signal: 3572-3576(+)
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0028493
Genomic location  G-integra Help Chromosome 1
Location 1q42.13
Position 229652590- 229694437
Strand -
Possible duplicated location(s) NA
Gene structure 13 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:23456
KEGG GENES KEGG GENES(23456)
GeneCard GeneCardABCB10*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000091862
Predicted CDS 39..2255;  738[aa];  Orientation:+3; 
Codon Adaptation Index (CAI). 0.728
Database links RefSeq NP_036221
UniProt Q9NRK6
CCDS CCDS1580

Motif information
ORF

length(738),orf(39:2255)
MRGPPAWPLRLLEPPSPAEPGRLLPVACVWAAASRVPGSLSPFTGLRPAR
LWGAGPALLWGVGAARRWRSGCRGGGPGASRGVLGLARLLGLWARGPGSC
RCGAFAGPGAPRLPRARFPGGPAAAAWAGDEAWRRGPAAPPGDKGRLRPA
AAGLPEARKLLGLAYPERRRLAAAVGFLTMSSVISMSAPFFLGKIIDVIY
TNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTS
LFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQA
SVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQA
TQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFG
ATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSS
FYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFA
YPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGT
ISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTA
EEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLK
NPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANM
VAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQSFISA*
a.a.
length
InterPro Name
length(316), motif(158:473) 316 IPR011527 ABC transporter type 1, transmembrane domain [Domain]
length(286), motif(172:457) 286 IPR011527 ABC transporter type 1, transmembrane domain [Domain]
length(247), motif(487:733) 247 IPR027417 P-loop containing nucleoside triphosphate hydrolase [Domain]
length(236), motif(491:726) 236 IPR027417 P-loop containing nucleoside triphosphate hydrolase [Domain]
length(240), motif(492:731) 240 IPR003439 ABC transporter-like [Domain]
length(152), motif(511:662) 152 IPR003439 ABC transporter-like [Domain]
length(196), motif(519:714) 196 IPR003593 AAA+ ATPase domain [Domain]
length(15), motif(634:648) 15 IPR017871 ABC transporter, conserved site [Conserved_site]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000261638
H-Inv cluster ID Locus viewHIX0028493
Accession number BC064930.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help Representative H-Inv IDRepresentative transcript; 
Coding potential  Help Protein coding; 
Definition ATP-binding cassette sub-family B member 10, mitochondrial; ATP-binding cassette transporter 10; ABC transporter 10 protein; Mitochondrial ATP-binding cassette 2; M-ABC2; Precursor;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (Q9NRK6)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 77669931092247511829140152152431548933416710414169599741960886121269460ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol ABCB10
HGNC aliases NA
HGNC name ATP-binding cassette, sub-family B (MDR/TAP), member 10
DDBJ ABCB10
UniProt ABCB10
EC number NA
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000091862
No. of interaction 8
Interaction partner(s) HIP000028200HIP000042416HIP000059423HIP000065350HIP000068366HIP000097703HIP000109379HIP000133997
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:23456
KEGG GENES KEGG GENES(23456)
GeneCard GeneCardABCB10*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Human curated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function ATPase activity, coupled to transmembrane movement of substances (GO:0042626);  ATP binding (GO:0005524);  ATPase activity (GO:0016887); 
Biological process transport (GO:0006810); 
Cellular component integral to membrane (GO:0016021); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT plasma membrane;  peroxisome; 
Target P Not predicted
SOSUI membrane protein
TMHMM membrane protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
158 473 2hydA2 6e-48 15.8 316/323 f.37.1.1
492 718 1e69A 5e-49 20.3 217/263 c.37.1.12
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene AGhsA241621; 
Affymetrix
GeneChip
HG-Focus NA
HG-U133 223320_s_at; 
HG-U133A NA
HG-U133A_2 NA
HG-U133B 223320_s_at; 
HG-U133_Plus_2 223320_s_at; 
HG-U95 35458_r_at;  59294_at; 
HG-U95A 35458_r_at; 
HG-U95B NA
HG-U95C 59294_at; 
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 2384672;  2384673;  2384683;  2384687;  2459926;  2459927;  2459928;  2459929;  2459930;  2459933;  2459936;  2459940;  2459941;  2459944;  2459945;  2459949;  2459950;  2459952;  2459954;  2459956;  2459960;  2459961;  2459962;  2459963;  2459964;  3585625;  3585627;  3585628;  3585630;  3585632;  3585634;  3585635;  3585638;  3585640;  3585642;  3585644;  3613120;  3613121;  3613122;  3613124;  3613125;  3613127;  3613129;  3613131;  3613132;  3615145;  3615147;  3615150;  3615151;  3615153;  3615154;  3615155;  3615157;  3615159;  3615160;  3615163;  3615165;  4038851;  4038853;  4038854;  4038856;  4038857;  4038858;  4038860;  4038862;  4038863;  4038865;  4038866;  4038867; 
HuGeneFL U18237_at; 
Agilent Human 1A Oligo Microarray:PGID215 A_23_P201918; 
Whole Human Genome Oligo Microarray:PGID247 A_23_P201918;  A_24_P274073;  A_24_P324449;  A_32_P23624; 
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Evolutionary information  Evola Help Last modified:27-May-2015
Relationship Species Accession number MGI Links
Orthology Mus sp. (Mouse) BC054793 MGI:1860508 G-integraG-integra
Orthology Rattus sp. (Rat) BC089900 G-integraG-integra
Orthology Canis sp. (Dog) ENSCAFT00000019279 G-integraG-integra
Orthology Gallus sp. (Chicken) ENSGALT00000018079 G-integraG-integra
Orthology Oryzias sp. (Medaka) ENSORLT00000013666 G-integraG-integra
Orthology Pongo sp. (Orangutan) ENSPPYT00000000136 G-integraG-integra
Orthology Tetraodon sp. (Tetraodon) GSTENT00032810001 G-integraG-integra
Orthology Takifugu sp. (Fugu) SINFRUT00000158953 G-integraG-integra
Orthology Macaca sp. (Macaque) XM_001082734 G-integraG-integra
Orthology Bos sp. (Cow) XM_001256448 G-integraG-integra
Orthology Danio sp. (Zebrafish) XM_001343182 G-integraG-integra
Orthology Monodelphis sp. (Opossum) XM_001379070 G-integraG-integra
Orthology Equus sp. (Horse) XM_001496372 G-integraG-integra
Orthology Pan sp. (Chimpanzee) XR_023717 G-integraG-integra
Phylogenetic tree [View by ATV]
Neighbor-joining (phb) 
Related H-InvDB links EvolaEvoladN/dS (under constraction); 

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
16 .. 16 G/A rs72559415 - 5'UTR
122 .. 122 C/G rs76878151 - CDS Nonsynonymous[Cys28Trp]
289 .. 289 T/C rs138947511 - CDS Nonsynonymous[Leu84Pro]
486 .. 486 G/T rs4148756 + CDS Nonsynonymous[Ala150Ser]
575 .. 575 G/A rs12080811 - CDS Synonymous[Thr179Thr]
590 .. 590 C/T rs138482043 - CDS Synonymous[Ile184Ile]
620 .. 620 G/T rs56312138 - CDS Nonsynonymous[Lys194Asn]
663 .. 663 G/A rs200713703 - CDS Nonsynonymous[Asp209Asn]
664 .. 664 A/G rs141170788 - CDS Nonsynonymous[Asp209Gly]
676 .. 676 G/A rs199764924 - CDS Nonsynonymous[Arg213His]
690 .. 690 C/T rs149118203 - CDS Nonsynonymous[Leu218Phe]
762 .. 762 C/G rs17584642 - CDS Nonsynonymous[Arg242Gly]
801 .. 801 A/G rs200640148 - CDS Nonsynonymous[Ile255Val]
838 .. 838 G/A rs149933923 - CDS Nonsynonymous[Arg267His]
839 .. 839 C/G rs201552069 - CDS Synonymous[Arg267Arg]
926 .. 926 C/T rs146106517 - CDS Synonymous[Ala296Ala]
936 .. 936 G/C rs144276366 - CDS Nonsynonymous[Ala300Pro]
941 .. 941 T/C rs3738187 - CDS Synonymous[Ser301Ser]
964 .. 964 T/G rs148378636 - CDS Nonsynonymous[Phe309Cys]
976 .. 976 A/C rs200265567 - CDS Nonsynonymous[Asn313Thr]
992 .. 992 T/C rs201195916 - CDS Synonymous[Val318Val]
998 .. 998 C/T rs188771123 - CDS Synonymous[Ser320Ser]
1021 .. 1021 T/C rs200635064 - CDS Nonsynonymous[Ile328Thr]
1031 .. 1031 T/C rs201980736 - CDS Synonymous[Ile331Ile]
1039 .. 1039 G/A rs138468815 - CDS Nonsynonymous[Arg334Gln]
1046 .. 1046 A/G rs146966923 - CDS Synonymous[Leu336Leu]
1048 .. 1048 G/A rs138708587 - CDS Nonsynonymous[Arg337Gln]
1060 .. 1060 A/C rs151011321 - CDS Nonsynonymous[Lys341Thr]
1098 .. 1098 G/A rs202102593 - CDS Nonsynonymous[Ala354Thr]
1190 .. 1190 A/T rs140358686 - CDS Synonymous[Val384Val]
1218 .. 1218 G/A rs143346649 - CDS Nonsynonymous[Ala394Thr]
1241 .. 1241 A/T rs145738622 - CDS Synonymous[Ala401Ala]
1359 .. 1359 G/A rs201559501 - CDS Nonsynonymous[Val441Ile]
1380 .. 1380 C/T rs60023878 - CDS Synonymous[Leu448Leu]
1396 .. 1396 C/T rs139689788 - CDS Nonsynonymous[Ser453Leu]
1427 .. 1427 G/C rs202239030 - CDS Synonymous[Gly463Gly]
1448 .. 1448 G/A rs138740992 - CDS Synonymous[Glu470Glu]
1451 .. 1451 A/G rs113018114 - CDS Synonymous[Arg471Arg]
1452 .. 1452 G/C rs72751738 - CDS Nonsynonymous[Glu472Gln]
1472 .. 1472 C/A rs57503359 - CDS Nonsynonymous[Asn478Lys]
1473 .. 1473 G/A rs192614060 - CDS Nonsynonymous[Glu479Lys]
1479 .. 1479 G/A rs143177165 - CDS Nonsynonymous[Val481Ile]
1521 .. 1521 A/G rs143054600 - CDS Nonsynonymous[Lys495Glu]
1587 .. 1587 A/G rs137896558 - CDS Nonsynonymous[Ile517Val]
1592 .. 1592 G/A rs140426197 - CDS Synonymous[Pro518Pro]
1606 .. 1606 C/T rs144786024 - CDS Nonsynonymous[Thr523Met]
1610 .. 1610 A/C rs200978146 - CDS Synonymous[Ala524Ala]
1611 .. 1611 C/T rs143285817 - CDS Synonymous[Leu525Leu]
1641 .. 1641 A/G rs201665849 - CDS Nonsynonymous[Thr535Ala]
1645 .. 1645 T/A rs200997396 - CDS Nonsynonymous[Val536Glu]
1670 .. 1670 C/T rs148725750 - CDS Synonymous[Tyr544Tyr]
1671 .. 1671 G/A rs35698797 - CDS Nonsynonymous[Asp545Asn]
1713 .. 1713 C/T rs188888716 - CDS Nonsynonymous[Arg559Cys]
1760 .. 1760 T/A rs147525990 - CDS Nonsynonymous[Ser574Arg]
1886 .. 1886 C/T rs186898100 - CDS Synonymous[Ile616Ile]
1923 .. 1923 G/T rs182613011 - CDS AA-STOP[Glu629*]
1995 .. 1995 A/G rs150546926 - CDS Nonsynonymous[Lys653Glu]
2006 .. 2006 C/G rs115501701 - CDS Synonymous[Leu656Leu]
2038 .. 2038 A/G rs141486923 - CDS Nonsynonymous[Glu667Gly]
2071 .. 2071 G/A rs185229946 - CDS Nonsynonymous[Arg678Gln]
2083 .. 2083 G/A rs201773661 - CDS Nonsynonymous[Gly682Glu]
2089 .. 2089 C/T rs117077784 - CDS Nonsynonymous[Thr684Met]
2128 .. 2128 A/G rs115488729 - CDS Nonsynonymous[Asn697Ser]
2173 .. 2173 A/G rs144991345 - CDS Nonsynonymous[Tyr712Cys]
2210 .. 2210 G/A rs141003292 - CDS Synonymous[Gly724Gly]
2211 .. 2211 A/G rs145356391 - CDS Nonsynonymous[Ile725Val]
2406 .. 2406 C/T rs182273646 - 3'UTR
2558 .. 2558 C/G rs189478483 - 3'UTR
2708 .. 2708 A/C rs60272247 - 3'UTR
2936 .. 2936 A/T rs15789 + 3'UTR
2943 .. 2943 G/C rs56865478 - 3'UTR
2952 .. 2952 A/G rs183637416 - 3'UTR
3011 .. 3011 G/A rs141284292 - 3'UTR
3166 .. 3166 A/C rs138822742 - 3'UTR
3195 ^ 3196 -/T rs35151282 - 3'UTR
3229 .. 3229 C/G rs76055669 - 3'UTR
3235 .. 3235 A/G rs113870511 - 3'UTR
3483 .. 3483 A/C rs1053512 + 3'UTR
3556 ^ 3557 -/T rs35400857 - 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer