H-InvDB x AHG DB
Transcript view
H-InvDB_9.0 released on May 27, 2015.
Search by for Advanced Search
Home Quick guide Navi BLAST Site map Download Contact us Help
H-Invitational ID: HIT000261932 Accession number: BC065525 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Beta-adducin; Erythrocyte adducin subunit beta;
 
 

Transcript original information
Accession number BC065525.1
CAGE tag ID NA
EST ID NA
Clone Number MGC:74968 IMAGE:6142886
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (ADD2) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (ADD2);
Sequence data provider NA
Annotation project NA
Length of cDNA 3777[bp] (No. of exon:16)[A:982 T:760 G:1012 C:1023]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type Eye, retinoblastoma
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA Site: 3739(+)
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) CAGGAG;  TAGAAG; 
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0029808
Genomic location  G-integra Help Chromosome 2
Location 2p13.3
Position 70889264- 70994847
Strand -
Possible duplicated location(s) NA
Gene structure 16 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:119
KEGG GENES KEGG GENES(119)
GeneCard GeneCardADD2*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000097059
Predicted CDS 266..2446;  726[aa];  Orientation:+2; 
Codon Adaptation Index (CAI). 0.815

Motif information
ORF

length(726),orf(266:2446)
MSEETVPEAASPPPPQGQPYFDRFSEDDPEYMRLRNRAADLRQDFNLMEQ
KKRVTMILQSPSFREELEGLIQEQMKKGNNSSNIWALRQIADFMASTSHA
VFPTSSMNVSMMTPINDLHTADSLNLAKGERLMRCKISSVYRLLDLYGWA
QLSDTYVTLRVSKEQDHFLISPKGVSCSEVTASSLIKVNILGEVVEKGSS
CFPVDTTGFCLHSAIYAARPDVRCIIHLHTPATAAVSAMKWGLLPVSHNA
LLVGDMAYYDFNGEMEQEADRINLQKCLGPTCKILVLRNHGVVALGDTVE
EAFYKIFHLQAACEIQVSALSSAGGVENLILLEQEKHRPHEVGSVQWAGS
TFGPMQKSRLGEHEFEALMRMLDNLGYRTGYTYRHPFVQEKTKHKSEVEI
PATVTAFVFEEDGAPVPALRQHAQKQQKEKTRWLNTPNAYLRVNVADEVQ
RSMGSPRPKTTWMKADEVEKSSSGMPIRIENPNQFVPLYTDPQEVLEMRN
KIREQNRQDVKSAGPQSQLLASVIAEKSRSPSTESQLMSKGDEDTKDDSE
ETVPNPFSQLTDQELEEYKKEVERKKLELDGEKETAPEEPGSPAKSAPAS
PVQSPAKEAETKSPLVSPSKSLEEGTKKTETSKAATTEPETTQPEGVVVN
GREEEQTAEEILSKGLSQMTTSADTDVDTSKDKTESVTSGPMSPEGSPSK
SPSKKKKKFRTPSFLKKSKKKEKVES*
a.a.
length
InterPro Name
length(726), motif(1:726) 726 IPR027773 Beta-adducin [Family]
length(193), motif(130:322) 193 IPR001303 Class II aldolase/adducin N-terminal [Domain]
length(206), motif(130:335) 206 IPR001303 Class II aldolase/adducin N-terminal [Domain]
length(183), motif(135:317) 183 IPR001303 Class II aldolase/adducin N-terminal [Domain]
length(182), motif(136:317) 182 IPR001303 Class II aldolase/adducin N-terminal [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000261932
H-Inv cluster ID Locus viewHIX0029808
Accession number BC065525.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO;  Splicing isoformSplicing isoform
Coding potential  Help Protein coding; 
Definition Beta-adducin; Erythrocyte adducin subunit beta;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (P35612)  [Identity/coverage = 99.862%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 184060385667988810272129510581470203915489334158156212140669221697133ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol ADD2
HGNC aliases NA
HGNC name adducin 2 (beta)
DDBJ ADD2
UniProt ADD2
EC number NA
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000097059
No. of interaction 11
Interaction partner(s) HIP000025285HIP000026208HIP000029340HIP000030685HIP000033437HIP000033560HIP000042542HIP000043538HIP000043538HIP000060745HIP000082857
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:119
KEGG GENES KEGG GENES(119)
GeneCard GeneCardADD2*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
FR ID FR181793
Accession
Description
Location
PMID
FR ID FR234658
Accession
Description
Location
PMID

Gene ontology information
Cellular component cytoskeleton (GO:0005856); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT nuclear;  cytosol; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
130 340 1dzuP 4e-52 19.2 203/209 c.74.1.1
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene AGhsB140706;  AGhsB140806;  AGhsB140906; 
Affymetrix
GeneChip
HG-Focus NA
HG-U133 205268_s_at; 
HG-U133A 205268_s_at; 
HG-U133A_2 205268_s_at; 
HG-U133B NA
HG-U133_Plus_2 205268_s_at; 
HG-U95 36051_s_at;  36052_at; 
HG-U95A 36051_s_at;  36052_at; 
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 2558755;  2558756;  2558765;  2558767;  2558768;  2558772;  2558774;  2558776;  2558780;  2558781;  2558783;  2558790;  2558791;  2558792;  2558798;  2558799;  2558800;  2558801;  2558805;  2558815;  2558816; 
HuGeneFL S81083_cds1_at;  X58199_s_at; 
Agilent Human 1A Oligo Microarray:PGID215 A_23_P209856; 
Whole Human Genome Oligo Microarray:PGID247 A_23_P209856;  A_23_P421436; 
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
86 .. 86 C/T rs181430958 - 5'UTR
256 .. 256 C/T rs188664399 - 5'UTR
260 .. 260 G/A rs199889944 - 5'UTR
264 .. 264 A/G rs62642474 - 5'UTR
272 .. 272 G/A rs200519011 - CDS Nonsynonymous[Glu3Lys]
312 .. 312 A/G rs201443444 - CDS Nonsynonymous[Gln16Arg]
315 .. 315 G/A rs34241538 + CDS Nonsynonymous[Gly17Glu]
347 .. 347 G/A rs4986 + CDS Nonsynonymous[Asp28Asn]
382 .. 382 G/A rs141187526 - CDS Synonymous[Ala39Ala]
390 .. 390 G/A rs144732476 - CDS Nonsynonymous[Arg42Gln]
397 .. 397 C/G rs138167651 - CDS Nonsynonymous[Asp44Glu]
464 .. 464 C/T rs114456016 - CDS Synonymous[Leu67Leu]
471 .. 471 G/T rs149147182 - CDS Nonsynonymous[Gly69Val]
517 .. 517 C/A rs17006140 - CDS Synonymous[Ile84Ile]
526 .. 526 G/A rs144778680 - CDS Synonymous[Leu87Leu]
535 .. 535 C/T rs200212314 - CDS Synonymous[Ile90Ile]
536 .. 536 G/A rs150703767 - CDS Nonsynonymous[Ala91Thr]
558 .. 558 C/G rs4987 + CDS Nonsynonymous[Ser98Cys]
574 .. 574 G/A rs144423262 - CDS Synonymous[Pro103Pro]
653 .. 653 G/A rs75081591 - CDS Nonsynonymous[Glu130Lys]
662 .. 662 A/C rs145968821 - CDS Nonsynonymous[Met133Leu]
703 .. 703 C/G rs114904807 - CDS Synonymous[Leu146Leu]
765 .. 765 A/G rs138007719 - CDS Nonsynonymous[His167Arg]
811 .. 811 G/A rs150383515 - CDS Synonymous[Ala182Ala]
818 .. 818 C/T rs200581515 - CDS Synonymous[Leu185Leu]
828 .. 828 T/A rs7425188 - CDS Nonsynonymous[Val188Glu]
872 .. 872 C/T rs148091443 - CDS Nonsynonymous[Pro203Ser]
889 .. 889 C/T rs147916626 - CDS Synonymous[Gly208Gly]
904 .. 904 G/A rs144869244 - CDS Synonymous[Ser213Ser]
916 .. 916 A/G rs181512905 - CDS Synonymous[Ala217Ala]
929 .. 929 G/A rs144714020 - CDS Nonsynonymous[Val222Met]
938 .. 938 A/G rs200730724 - CDS Nonsynonymous[Ile225Val]
951 .. 951 A/G rs201811808 - CDS Nonsynonymous[His229Arg]
1097 .. 1097 C/G rs145329028 - CDS Nonsynonymous[Leu278Val]
1123 .. 1123 G/A rs139387703 - CDS Synonymous[Val286Val]
1124 .. 1124 C/T rs111700825 - CDS Synonymous[Leu287Leu]
1139 .. 1139 G/T rs139808041 - CDS Nonsynonymous[Val292Leu]
1174 .. 1174 T/C rs4989 + CDS Synonymous[Phe303Phe]
1219 .. 1219 G/A rs142433540 - CDS Synonymous[Ser318Ser]
1235 .. 1235 G/A rs201864311 - CDS Nonsynonymous[Gly324Arg]
1261 .. 1261 G/A rs144529989 - CDS Synonymous[Leu332Leu]
1269 .. 1269 A/T rs61030669 - CDS Nonsynonymous[Glu335Val]
1270 .. 1270 G/T rs4982 + CDS Nonsynonymous[Glu335Asp]
1276 .. 1276 C/A rs142392995 - CDS Nonsynonymous[His337Gln]
1278 .. 1278 G/A rs146561886 - CDS Nonsynonymous[Arg338Gln]
1410 .. 1410 C/T rs145886276 - CDS Nonsynonymous[Thr382Met]
1411 .. 1411 G/A rs139827624 - CDS Synonymous[Thr382Thr]
1473 .. 1473 C/T rs199834771 - CDS Nonsynonymous[Thr403Met]
1487 .. 1487 G/A rs34196785 + CDS Nonsynonymous[Val408Met]
1497 .. 1497 A/G rs150772862 - CDS Nonsynonymous[Glu411Gly]
1510 .. 1510 G/A rs148662450 - CDS Synonymous[Pro415Pro]
1572 .. 1572 C/T rs201022450 - CDS Nonsynonymous[Thr436Met]
1573 .. 1573 G/T rs143711744 - CDS Synonymous[Thr436Thr]
1580 .. 1580 G/A rs17855969 - CDS Nonsynonymous[Ala439Thr]
1641 .. 1641 A/G rs201449367 - CDS Nonsynonymous[Lys459Arg]
1663 .. 1663 C/T rs188058882 - CDS Synonymous[Asp466Asp]
1693 .. 1693 G/A rs34884423 + CDS Synonymous[Pro476Pro]
1698 .. 1698 G/A rs150426440 - CDS Nonsynonymous[Arg478His]
1702 .. 1702 C/T rs199802003 - CDS Synonymous[Ile479Ile]
1767 .. 1767 A/G rs112879637 - CDS Nonsynonymous[Lys501Arg]
1774 .. 1774 A/C rs145174076 - CDS Synonymous[Arg503Arg]
1804 .. 1804 G/C rs115841739 - CDS Synonymous[Ala513Ala]
1831 .. 1831 C/T rs148402316 - CDS Synonymous[Ser522Ser]
1840 .. 1840 C/G rs201133279 - CDS Synonymous[Ala525Ala]
1848 .. 1848 G/C rs149689098 - CDS Nonsynonymous[Ser528Thr]
1851 .. 1851 G/T rs114311724 - CDS Nonsynonymous[Arg529Leu]
1892 .. 1892 G/A rs139586218 - CDS Nonsynonymous[Glu543Lys]
1920 .. 1920 C/T rs114897963 - CDS Nonsynonymous[Thr552Met]
1942 .. 1942 A/G rs115445925 - CDS Synonymous[Gln559Gln]
2082 .. 2082 C/T rs141431061 - CDS Nonsynonymous[Ala606Val]
2090 .. 2090 G/A rs138503054 - CDS Nonsynonymous[Ala609Thr]
2097 .. 2097 C/A rs140129786 - CDS Nonsynonymous[Thr611Lys]
2143 .. 2143 T/G rs199908987 - CDS Synonymous[Thr626Thr]
2168 .. 2168 G/A rs149050833 - CDS Nonsynonymous[Ala635Thr]
2171 .. 2171 A/G rs145267894 - CDS Nonsynonymous[Thr636Ala]
2197 .. 2197 G/A rs115476558 - CDS Synonymous[Pro644Pro]
2254 .. 2254 C/A rs4985 + CDS Nonsynonymous[Ser663Arg]
2265 .. 2265 G/A rs147439886 - CDS Nonsynonymous[Ser667Asn]
2290 .. 2290 G/A rs139265334 - CDS Synonymous[Thr675Thr]
2410 .. 2410 G/A rs141473907 - CDS Synonymous[Leu715Leu]
2412 .. 2412 A/T rs138841596 - CDS Nonsynonymous[Lys716Ile]
2486 .. 2486 C/G rs144829163 - 3'UTR
2651 .. 2651 C/A rs115570420 - 3'UTR
2865 .. 2865 C/T rs1043136 + 3'UTR
3154 .. 3154 C/T rs149831214 - 3'UTR
3202 .. 3202 T/C rs186901862 - 3'UTR
3353 .. 3353 C/T rs34662357 - 3'UTR
3392 .. 3392 G/A rs35480486 - 3'UTR
3403 .. 3403 C/T rs139845720 - 3'UTR
3412 .. 3412 T/C rs13384050 - 3'UTR
3444 .. 3444 C/T rs115824829 - 3'UTR
3452 .. 3452 G/A rs147275057 - 3'UTR
3496 .. 3496 A/G rs183004119 - 3'UTR
3505 .. 3505 T/C rs17698193 - 3'UTR
3631 .. 3631 G/A rs143938189 - 3'UTR
3679 .. 3679 G/A rs72899633 - 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
Type Start End Strand
MIR3 2566 2730 -
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer