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H-Invitational ID: HIT000268318 Accession number: CR533470 Created date: 26-Mar-2013 Last modified: 27-May-2015 Definition: Claudin-12;

		Select format Flat file XML file Nucleotide sequence fasta Protein sequence fasta

Transcript original information Accession number CR533470.1 CAGE tag ID NA EST ID NA Clone Number RZPDo834D0517D Experimental resources   NBRC ; HGPD ; Antibody (CLDN12) ; Catalog (CLDN12); Sequence data provider NA Annotation project NA Length of cDNA 792[bp] (No. of exon:1)[A:170 T:234 G:172 C:216] Devision HUM Molecular type mRNA Library origin Cell type NA Tissue type NA Develpmental stage NA

Sequence quality information CDS feature Complete CDS Kozak sequence NA PolyA NA Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) NA Transcript quality feature NA Notes NA

ATGGGCTGTCGGGATGTCCACGCAGCCACAGTCCTTTCCTTCCTGTGTGG AATCGCCTCAGTAGCATGCCTCTTTGCAGGGACTCTGCTTCCCAACTGGA GAAAATTACGATTGATCACATTCAACAGAAACGGGAAGAACCTGACTGTT TACACAGGCCTGTGGGTGAAATGTGCCCGGTATGACGGGAGCAGTGACTG CCTGATGTACGACACTACTTGGTACTCATCAGTTGACCAGCTGGACCTGC GTGTCCTCCAGTTTGCCCTACCCCTCAGCATGCTGATCGCCATGGGTGCC CTGCTGCTCTGCCTGATTGGAATGTGCAACACTGCCTTCAGGTCCTCGGT GCCCAACATCAAACTGGCCAAGTGTCTGGTCAATAGTGCAGGTTGCCACC TGGTGGCTGGGCTGCTATTTTTCCTGGCAGGTACTGTGAGCCTCTCCCCA TCTATCTGGGTCATCTTTTATAACATCCATCTGAACAAGAAGTTTGAGCC AGTCTTTTCATTTGACTATGCAGTGTATGTCACTATTGCTAGTGCTGGGG GCCTGTTTATGACTTCCCTTATACTATTTATTTGGTATTGTACATGCAAA TCTTTGCCTTCTCCTTTCTGGCAACCATTGTACTCCCATCCACCCAGTAT GCATACTTACTCACAGCCCTATTCAGCACGCCCTCGCCTCTCTGCCATTG AAATTGACATTCCAGTAGTTTCACACACCACTTAATGGGGAAATAGTTAA TTGTTAAAGAAAACTTCTTGTAGCCTCACATTCCCCTTGTGC

Gene structure information

H-Inv cluster ID		HIX0006831
Genomic location	Chromosome	7
	Location	7q21.13
	Position	90041991- 90042782
	Strand	+
Possible duplicated location(s)		NA
Gene structure		1 exon(s)
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:9069;
	KEGG GENES	KEGG GENES(9069);
	GeneCard	CLDN12;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000055159 Predicted CDS 1..735;  244[aa];  Orientation:+1;  Codon Adaptation Index (CAI). 0.765

MGCRDVHAATVLSFLCGIASVACLFAGTLLPNWRKLRLITFNRNGKNLTV YTGLWVKCARYDGSSDCLMYDTTWYSSVDQLDLRVLQFALPLSMLIAMGA LLLCLIGMCNTAFRSSVPNIKLAKCLVNSAGCHLVAGLLFFLAGTVSLSP SIWVIFYNIHLNKKFEPVFSFDYAVYVTIASAGGLFMTSLILFIWYCTCK SLPSPFWQPLYSHPPSMHTYSQPYSARPRLSAIEIDIPVVSHTT*

Motif information

	a.a. length	InterPro	Name
	16	IPR013287	Claudin-12 [Family]
	15	IPR017974	Claudin, conserved site [Conserved_site]
	17	IPR013287	Claudin-12 [Family]
	13	IPR013287	Claudin-12 [Family]
	12	IPR013287	Claudin-12 [Family]

Gene function information

H-Inv ID		HIT000268318
H-Inv cluster ID		HIX0006831
Accession number		CR533470.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		NO;
Coding potential		Protein coding;
Definition		Claudin-12;
Similarity category		Category: Identical to known human protein(Category I).
		Identical to known human protein (P56749)  [Identity/coverage = 98.77%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence		Protein evidence
PubMed ID		11230166;  12690205;  12853948;  15489334;  18669648;  19690332;  ALL;
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	CLDN12
	HGNC aliases	NA
	HGNC name	claudin 12
	DDBJ	CLDN12
	UniProt	CLDN12
EC number		NA
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000055159
	No. of interaction	4
	Interaction partner(s)	HIP000025790;  HIP000053638;  HIP000079334;  HIP000088109;
	BIND	NA
	DIP	NA
	MINT	MINT-65603;
	HPRD	02538;  03799;  18125;
	IntAct	NA
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:9069;
	KEGG GENES	KEGG GENES(9069);
	GeneCard	CLDN12;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Auto-annotated
Notes		NA
Related H-InvDB links		Gene family;  Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Molecular function	structural molecule activity (GO:0005198);
Cellular component	tight junction (GO:0005923);

Subcellular localization information

Last modified:27-May-2015

WoLF PSORT	plasma membrane;  endoplasmic;  extracellular;
Target P	signal peptide
SOSUI	membrane protein
TMHMM	membrane protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Gene expression information

Last modified:27-May-2015

Tissue-specific expression			NA
Probe information	AceGene		AGhsA201522;
	Affymetrix GeneChip	HG-Focus	NA
		HG-U133	NA
		HG-U133A	NA
		HG-U133A_2	NA
		HG-U133B	NA
		HG-U133_Plus_2	NA
		HG-U95	NA
		HG-U95A	NA
		HG-U95B	NA
		HG-U95C	NA
		HG-U95D	NA
		HG-U95E	NA
		HG-U95Av2	NA
		HuEx-1_0	3012030;  3012031;
		HuGeneFL	NA
	Agilent	Human 1A Oligo Microarray:PGID215	A_23_P412515;
		Whole Human Genome Oligo Microarray:PGID247	A_23_P412515;
Related H-InvDB links			H-ANGEL;  DNAProbeLocator;

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 11 .. 11 G/T rs200372770 + CDS Nonsynonymous[Arg4Leu] 12 .. 12 G/T rs201163165 + CDS Synonymous[Arg4Arg] 132 .. 132 C/T rs140108357 + CDS Synonymous[Asn44Asn] 186 .. 186 C/T rs17862175 + CDS Synonymous[Asp62Asp] 187 .. 187 G/A rs200164858 + CDS Nonsynonymous[Gly63Arg] 210 .. 210 C/T rs185427290 + CDS Synonymous[Tyr70Tyr] 231 .. 231 A/G rs200281270 + CDS Synonymous[Ser77Ser] 292 .. 292 A/G rs76988207 + CDS Nonsynonymous[Met98Val] 315 .. 315 G/T rs79632494 + CDS Synonymous[Leu105Leu] 348 .. 348 G/A rs34378679 - CDS Synonymous[Ser116Ser] 365 .. 365 T/A rs146056566 + CDS Nonsynonymous[Leu122Gln] 473 .. 473 A/G rs139669349 + CDS Nonsynonymous[Asn158Ser] 553 .. 553 C/T rs149798695 + CDS Synonymous[Leu185Leu] 579 .. 579 T/G rs144717277 + CDS Nonsynonymous[Phe193Leu] 594 .. 594 A/T rs148668482 + CDS Synonymous[Thr198Thr] 600 .. 600 A/G rs142157384 + CDS Synonymous[Lys200Lys] 667 .. 667 C/T rs189780617 + CDS Nonsynonymous[Pro223Ser] 676 .. 676 G/A rs147857522 + CDS Nonsynonymous[Ala226Thr] 679 .. 679 C/T rs141430153 + CDS Nonsynonymous[Arg227Cys] 701 .. 701 A/C rs145275926 + CDS Nonsynonymous[Glu234Ala] 767 .. 767 C/A rs182726869 + 3'UTR 775 .. 775 C/G rs147269114 + 3'UTR  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  No data available Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;