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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000325535 Accession number: Y09615 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Transcription termination factor, mitochondrial; Mitochondrial transcription termination factor 1; mTERF; Precursor;
 
 

Transcript original information
Accession number Y09615.1
CAGE tag ID NA
EST ID NA
Clone Number NA
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (MTERF1) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (MTERF1);
Sequence data provider NA
Annotation project NA
Length of cDNA 1995[bp] (No. of exon:3)[A:673 T:573 G:417 C:332]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type NA
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0006835
Genomic location  G-integra Help Chromosome 7
Location 7q21.2
Position 91502190- 91510016
Strand -
Possible duplicated location(s) NA
Gene structure 3 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:7978
KEGG GENES KEGG GENES(7978)
GeneCard GeneCardMTERF1*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000090122
Predicted CDS 78..1277;  399[aa];  Orientation:+3; 
Codon Adaptation Index (CAI). 0.7
Database links RefSeq NP_008911
UniProt Q99551
CCDS CCDS5621

Motif information
ORF

length(399),orf(78:1277)
MQSLSLGQTSISKGLNYLTIMAPGNLWHMRNNFLFGSRCWMTRFSAENIF
KSVSFRLFGVKCHNTDSEPLKNEDLLKNLLTMGVDIDMARKRQPGVFHRM
ITNEQDLKMFLLSKGASKEVIASIISRYPRAITRTPENLSKRWDLWRKIV
TSDLEIVNILERSPESFFRSNNNLNLENNIKFLYSVGLTRKCLCRLLTNA
PRTFSNSLDLNKQMVEFLQAAGLSLGHNDPADFVRKIIFKNPFILIQSTK
RVKANIEFLRSTFNLNSEELLVLICGPGAEILDLSNDYARRSYANIKEKL
FSLGCTEEEVQKFVLSYPDVIFLAEKKFNDKIDCLMEENISISQIIENPR
VLDSSISTLKSRIKELVNAGCNLSTLNITLLSWSKKRYEAKLKKLSRFA*
a.a.
length
InterPro Name
length(323), motif(73:395) 323 IPR003690 Mitochodrial transcription termination factor [Family]
length(31), motif(122:152) 31 IPR003690 Mitochodrial transcription termination factor [Family]
length(33), motif(157:189) 33 IPR003690 Mitochodrial transcription termination factor [Family]
length(31), motif(194:224) 31 IPR003690 Mitochodrial transcription termination factor [Family]
length(32), motif(235:266) 32 IPR003690 Mitochodrial transcription termination factor [Family]
length(31), motif(311:341) 31 IPR003690 Mitochodrial transcription termination factor [Family]
length(31), motif(342:372) 31 IPR003690 Mitochodrial transcription termination factor [Family]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000325535
H-Inv cluster ID Locus viewHIX0006835
Accession number Y09615.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help Representative H-Inv IDRepresentative transcript;  Splicing isoformSplicing isoform
Coding potential  Help Protein coding; 
Definition Transcription termination factor, mitochondrial; Mitochondrial transcription termination factor 1; mTERF; Precursor;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (Q99551)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 9118945126902051285394815087485154893342054382620550934ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol MTERF1
HGNC aliases "mitochondrial transcription termination factor"
HGNC name mitochondrial transcription termination factor 1
DDBJ mTERF
UniProt MTERF
EC number NA
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000090122
No. of interaction 5
Interaction partner(s) HIP000025121HIP000055752HIP000055752HIP000064456HIP000182949
BIND NA
DIP NA
MINT MINT-8079030; 
HPRD 05496;  08428;  09210; 
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:7978
KEGG GENES KEGG GENES(7978)
GeneCard GeneCardMTERF1*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Human curated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function double-stranded DNA binding (GO:0003690); 
Biological process regulation of transcription, DNA-dependent (GO:0006355); 
Cellular component mitochondrion (GO:0005739); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT mitochondria;  peroxisome;  cytosol;  Other; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene AGhsA201403; 
Affymetrix
GeneChip
HG-Focus 204871_at; 
HG-U133 204871_at; 
HG-U133A 204871_at; 
HG-U133A_2 204871_at; 
HG-U133B NA
HG-U133_Plus_2 204871_at; 
HG-U95 41070_r_at; 
HG-U95A 41070_r_at; 
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 3012369;  3060944;  3060945;  3060946;  3060947;  3060948;  3060949;  3060952;  3060953;  3060954; 
HuGeneFL Y09615_at; 
Agilent Human 1A Oligo Microarray:PGID215 A_23_P111712;  A_23_P408108; 
Whole Human Genome Oligo Microarray:PGID247 A_23_P111712;  A_23_P408108; 
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Evolutionary information  Evola Help Last modified:27-May-2015
Relationship Species Accession number MGI Links
Orthology Rattus sp. (Rat) AJ292524 G-integraG-integra
Orthology Mus sp. (Mouse) AK016498 MGI:1903466 G-integraG-integra
Orthology Canis sp. (Dog) ENSCAFT00000003023 G-integraG-integra
Orthology Pongo sp. (Orangutan) ENSPPYT00000020767 G-integraG-integra
Orthology Tetraodon sp. (Tetraodon) GSTENT00032547001 G-integraG-integra
Orthology Takifugu sp. (Fugu) SINFRUT00000179138 G-integraG-integra
Orthology Macaca sp. (Macaque) XM_001092039 G-integraG-integra
Orthology Pan sp. (Chimpanzee) XM_001165566 G-integraG-integra
Orthology Bos sp. (Cow) XM_001252878 G-integraG-integra
Orthology Equus sp. (Horse) XM_001915496 G-integraG-integra
Orthology Danio sp. (Zebrafish) XM_001921720 G-integraG-integra
Phylogenetic tree [View by ATV]
Neighbor-joining (phb) 
Related H-InvDB links EvolaEvoladN/dS (under constraction); 

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
19 .. 19 C/G rs114279247 - 5'UTR
91 .. 91 C/G rs149288093 - CDS Nonsynonymous[Ser5Cys]
125 .. 125 C/T rs190619742 - CDS Synonymous[Asn16Asn]
127 .. 127 A/G rs186094669 - CDS Nonsynonymous[Tyr17Cys]
134 .. 134 C/G rs183726341 - CDS Synonymous[Thr19Thr]
151 .. 151 A/G rs138600221 - CDS Nonsynonymous[Asn25Ser]
166 .. 166 G/T rs150415937 - CDS Nonsynonymous[Arg30Ile]
172 .. 172 A/G rs143117433 - CDS Nonsynonymous[Asn32Ser]
200 .. 200 G/A rs199551651 - CDS Nonsynonymous[Met41Ile]
205 .. 205 G/A rs190837494 - CDS Nonsynonymous[Arg43Gln]
234 .. 234 G/A rs201580782 - CDS Nonsynonymous[Val53Ile]
271 .. 271 C/T rs144315661 - CDS Nonsynonymous[Thr65Ile]
282 .. 282 C/T rs146357360 - CDS Nonsynonymous[Pro69Ser]
311 .. 311 C/G rs142360964 - CDS Nonsynonymous[Asn78Lys]
313 .. 313 T/G rs147741556 - CDS AA-STOP[Leu79*]
338 .. 338 C/T rs17849384 - CDS Synonymous[Asp87Asp]
339 .. 339 A/C rs199603020 - CDS Nonsynonymous[Met88Leu]
346 .. 346 G/A rs200478408 - CDS Nonsynonymous[Arg90Lys]
426 .. 426 A/G rs148655332 - CDS Nonsynonymous[Ser117Gly]
441 .. 441 G/A rs201335490 - CDS Nonsynonymous[Ala122Thr]
486 .. 486 G/A rs202031297 - CDS Nonsynonymous[Glu137Lys]
498 .. 498 A/G rs181549251 - CDS Nonsynonymous[Lys141Glu]
582 .. 582 C/G rs148973867 - CDS Nonsynonymous[Arg169Gly]
631 .. 631 C/T rs145815151 - CDS Nonsynonymous[Ser185Leu]
652 .. 652 G/T rs199534810 - CDS Nonsynonymous[Cys192Phe]
661 .. 661 G/A rs200438840 - CDS Nonsynonymous[Arg195Gln]
662 .. 662 A/G rs200963298 - CDS Synonymous[Arg195Arg]
675 .. 675 G/A rs202042766 - CDS Nonsynonymous[Ala200Thr]
682 .. 682 G/A rs149835747 - CDS Nonsynonymous[Arg202His]
694 .. 694 A/G rs201515058 - CDS Nonsynonymous[Asn206Ser]
704 .. 704 T/C rs199929836 - CDS Synonymous[Asp209Asp]
716 .. 716 G/C/A rs139864199 - CDS
768 .. 768 G/A rs17856025 - CDS Nonsynonymous[Ala231Thr]
801 .. 801 C/G rs143980432 - CDS Nonsynonymous[Pro242Ala]
829 .. 829 G/A rs78445151 - CDS Nonsynonymous[Arg251Gln]
868 .. 868 A/G rs149530545 - CDS Nonsynonymous[Asn264Ser]
897 .. 897 A/G rs202197997 - CDS Nonsynonymous[Ile274Val]
900 .. 900 T/G rs150790142 - CDS Nonsynonymous[Cys275Gly]
950 .. 950 A/C rs139218723 - CDS Nonsynonymous[Arg291Ser]
956 .. 956 C/T rs141348801 - CDS Synonymous[Tyr293Tyr]
957 .. 957 G/A rs10266424 - CDS Nonsynonymous[Ala294Thr]
977 .. 977 G/A rs144031914 - CDS Synonymous[Leu300Leu]
988 .. 988 G/T rs143680014 - CDS Nonsynonymous[Gly304Val]
1071 .. 1071 A/G rs139119978 - CDS Nonsynonymous[Ile332Val]
1115 .. 1115 C/T rs146631456 - CDS Synonymous[Ile346Ile]
1127 .. 1127 G/T rs143800373 - CDS Synonymous[Arg350Arg]
1134 .. 1134 G/T rs138162673 - CDS Nonsynonymous[Asp353Tyr]
1144 .. 1144 T/C rs201314167 - CDS Nonsynonymous[Ile356Thr]
1174 .. 1174 T/G rs150470458 - CDS Nonsynonymous[Leu366Trp]
1255 .. 1255 A/G rs199652694 - CDS Nonsynonymous[Lys393Arg]
1311 .. 1311 A/G rs186202598 - 3'UTR
1337 .. 1337 A/G rs146299538 - 3'UTR
1346 .. 1346 A/C rs141993108 - 3'UTR
1347 .. 1347 A/T rs138814561 - 3'UTR
1650 .. 1650 A/G rs62466814 - 3'UTR
1727 .. 1727 G/A rs145034397 - 3'UTR
1778 .. 1778 G/C rs9008 - 3'UTR
1935 .. 1935 A/C rs11983332 - 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
Type Start End Strand
MLT1D 1273 1753 +
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer