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H-Invitational ID: HIT000384385 Accession number: AK225255 Created date: 26-Mar-2013 Last modified: 27-May-2015 Definition: Similar to Abelson tyrosine-protein kinase 2 isoform e.

		Select format Flat file XML file Nucleotide sequence fasta Protein sequence fasta

Transcript original information Accession number AK225255.1 CAGE tag ID NA EST ID NA Clone Number DMC00952 Experimental resources   NBRC ; HGPD ; Antibody (ABL2) ; Catalog (ABL2); Sequence data provider NA Annotation project NA Length of cDNA 1833[bp] (No. of exon:7)[A:504 T:471 G:458 C:400] Devision HUM Molecular type mRNA Library origin Cell type NA Tissue type dermoid cancer Develpmental stage NA

Sequence quality information CDS feature Complete CDS Kozak sequence NA PolyA Site: 1811(+) Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) CAGAAG;  Transcript quality feature NA Notes NA

AACTTTTGTGCTTCTGGGCAGAGGTATGGTCCTTGGGACAGTTCTCCTTC CACCTAATAGTTATGGCAGAGATCAGGACACTTCACTTTGCTGCCTGTGC ACTGAGGCCTCAGAATCTGCTCTACCCGACTTAACAGAAGCTTTGCATCG TCCCTATGGTTGTGATGTTGAACCCCAGGCACTAAATGAGGCTATCAGGT GGAGCTCCAAGGAGAACTTGCTCGGAGCCACTGAGAGTGACCCTAATCTC TTCGTTGCACTTTATGATTTTGTAGCAAGTGGTGATAACACACTCAGCAT CACTAAAGGTGAAAAGCTACGAGTCCTTGGTTACAACCAGAATGGTGAGT GGAGTGAAGTTCGCTCTAAGAATGGGCAGGGCTGGGTGCCAAGCAACTAC ATCACCCCAGTGAACAGCCTGGAAAAACACTCCTGGTACCATGGACCTGT GTCACGCAGTGCAGCTGAGTATCTGCTCAGCAGTCTAATCAATGGCAGCT TCCTGGTGCGAGAAAGTGAGAGTAGCCCTGGGCAGCTGTCCATCTCGCTC AGGTACGAGGGACGTGTGTATCACTACAGGATCAATACCACTGCAGATGG CAAGGTGTATGTGACTGCTGAGAGCCGCTTCAGCACCTTGGCAGAGCTTG TACACCATCACTCCACAGTGGCTGATGGGCTGGTGACAACATTACACTAC CCAGCACCCAAGTGTAATAAGCCTACAGTCTATGGTGTGTCCCCCATCCA CGACAAATGGGAAATGGAGCGAACAGATATTACCATGAAGCACAAACTTG GGGGCGGTCAGTATGGAGAGGTTTACGTTGGCGTCTGGAAGAAATACAGC CTTACAGTTGCTGTGAAAACATTGAAGGAAGATACCATGGAGGTAGAAGA ATTCCTGAAAGAAGCTGCAGTAATGAAGGAAATCAAGCATCCTAATCTGG TACAACTTTTAGGTGTGTGTACTTTGGAGCCACCATTTTACATTGTGACT GAATACATGCCATACGGGAATTTGCTGGATTACCTCCGAGAATGCAACCG AGAAGAGGTGACTGCAGTTGTGCTGCTCTACATGGCCACTCAGATTTCTT CTGCAATGGAGTACTTAGAGAAGAAGAATTTCATCCATAGAGATCTTGCA GCTCGTAACTGCCTAGTGGGAGAAAACCATGTGGTAAAAGTGGCTGACTT TGGCTTAAGTAGATTGATGACTGGAGACACTTATACTGCTCATGCTGGAG CCAAATTTCCTATTAAGTGGACAGCACCAGAGAGTCTTGCCTACAATACC TTCTCAATTAAATCTGACGTCTGGGGTAAGGTTGAAAGGGACTTTTTTCT GTGTCATTTTATTTTTTTTTTTATAAATGCCTTGATTCTTTAGAGCTTCT CTTACGATGTTCAGTATCCTCTACCTTTACCTGCCATTCTTCTTCAGTTA TTCAGCAAGCATTTGTTAAATACCTCCTATCTGCCAGGACTGTGTTAAGA ACTTTGCATAAACAGAAGTATAGGCCTGGTGTGGTGGCTCACGTTTGTAA TTACAGCACTTTGGGCCGAGATGGGTGGATCACTTGAGGTCAAGAGTTCG AGACCAGCCTGGCCAACATGGTGAACTCCCATCTCTACTAACTACAAAAA TTAGCCAGGCGTGGTGGCATGCGCCAGTAATCCCAGCTATTCAAGAGGCT GAAGGCTGAGGCAGGGGAGTTGCTTGAGCCTGGAGGGCAGAGGTTGCAGT GAGCCAAGATGGCGCCACTGCACTCCAGCCTGGGCAATAGAGCGAGACTC TGTCTAAAAGAAAAAAAAAAAAAAAAAAAAAAA

Gene structure information

H-Inv cluster ID		HIX0001374
Genomic location	Chromosome	1
	Location	1q25.2
	Position	179085983- 179112204
	Strand	-
Possible duplicated location(s)		NA
Gene structure		7 exon(s)
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:27;
	KEGG GENES	KEGG GENES(27);
	GeneCard	ABL2;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000174450 Predicted CDS 26..1393;  455[aa];  Orientation:+2;  Codon Adaptation Index (CAI). 0.737

MVLGTVLLPPNSYGRDQDTSLCCLCTEASESALPDLTEALHRPYGCDVEP QALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRV LGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYL LSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAES RFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERT DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVM KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVL LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTG DTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWGKVERDFFLCHFIFFFI NALIL*

Motif information

	a.a. length	InterPro	Name
	61	IPR001452	SH3 domain [Domain]
	86	IPR001452	SH3 domain [Domain]
	11	IPR001452	SH3 domain [Domain]
	57	IPR001452	SH3 domain [Domain]
	47	IPR001452	SH3 domain [Domain]
	16	IPR001452	SH3 domain [Domain]
	13	IPR001452	SH3 domain [Domain]
	112	IPR000980	SH2 domain [Domain]
	141	IPR000980	SH2 domain [Domain]
	84	IPR000980	SH2 domain [Domain]
	76	IPR000980	SH2 domain [Domain]
	91	IPR000980	SH2 domain [Domain]
	15	IPR000980	SH2 domain [Domain]
	11	IPR000980	SH2 domain [Domain]
	12	IPR000980	SH2 domain [Domain]
	11	IPR000980	SH2 domain [Domain]
	15	IPR000980	SH2 domain [Domain]
	202	IPR011009	Protein kinase-like domain [Domain]
	182	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
	204	IPR000719	Protein kinase domain [Domain]
	24	IPR017441	Protein kinase, ATP binding site [Binding_site]
	14	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
	19	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
	13	IPR008266	Tyrosine-protein kinase, active site [Active_site]
	11	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]

Gene function information

H-Inv ID		HIT000384385
H-Inv cluster ID		HIX0001374
Accession number		AK225255.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		NO;  Splicing isoform
Coding potential		Protein coding;
Definition		Similar to Abelson tyrosine-protein kinase 2 isoform e.
Similarity category		Category: Similar to known protein(Category II).
		Similar to known protein (NP_001129473)  [Identity/coverage = 100.0%/73.06%] to Homo sapiens protein.
Experimental evidence		Protein evidence
PubMed ID		NA
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	ABL2
	HGNC aliases	"v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)", "v-abl Abelson murine leukemia viral oncogene homolog 2", "c-abl oncogene 2, non-receptor tyrosine kinase"
	HGNC name	ABL proto-oncogene 2, non-receptor tyrosine kinase
	DDBJ	NA
	UniProt	NA
EC number		EC 2.7.10.2non-specific protein-tyrosine kinase;
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		04020 :Calcium signaling pathway;  04360 :Axon guidance;  04370 :VEGF signaling pathway;  04510 :Focal adhesion;  04520 :Adherens junction;  04530 :Tight junction;  04540 :Gap junction;  04630 :Jak-STAT signaling pathway;  04660 :T cell receptor signaling pathway;  04662 :B cell receptor signaling pathway;  04664 :Fc epsilon RI signaling pathway;  04670 :Leukocyte transendothelial migration;  04730 :Long-term depression;  04810 :Regulation of actin cytoskeleton;  04912 :GnRH signaling pathway;  04920 :Adipocytokine signaling pathway;  05120 :Epithelial cell signaling in Helicobacter pylori infection;  05130 :Pathogenic Escherichia coli infection - EHEC;  05131 :Pathogenic Escherichia coli infection - EPEC;
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000174450
	No. of interaction	NA
	Interaction partner(s)	NA
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	NA
	IntAct	NA
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:27;
	KEGG GENES	KEGG GENES(27);
	GeneCard	ABL2;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Auto-annotated
Notes		NA
Related H-InvDB links		Gene family;  Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Molecular function	transferase activity, transferring phosphorus-containing groups (GO:0016772);  ATP binding (GO:0005524);  protein kinase activity (GO:0004672);  protein binding (GO:0005515);
Biological process	protein amino acid phosphorylation (GO:0006468);

Subcellular localization information

Last modified:27-May-2015

WoLF PSORT	cytosol;  peroxisome;  plasma membrane;
Target P	Other
SOSUI	membrane protein
TMHMM	soluble protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified:27-May-2015

Start End PDB_ID E-value Identity Coverage SCOP_ID 74 131 1aboA 5e-15 91.4 58/58 b.34.2.1 139 180 2d7nA1 8e-04 22.0 41/80 b.1.18.10 164 433 1nw1A 1e-39 9.3 270/365 d.144.1.8

Related H-InvDB links GTOP

Gene expression information

Last modified:27-May-2015

Tissue-specific expression			liver;
Probe information	AceGene		NA
	Affymetrix GeneChip	HG-Focus	NA
		HG-U133	NA
		HG-U133A	NA
		HG-U133A_2	NA
		HG-U133B	NA
		HG-U133_Plus_2	NA
		HG-U95	NA
		HG-U95A	NA
		HG-U95B	NA
		HG-U95C	NA
		HG-U95D	NA
		HG-U95E	NA
		HG-U95Av2	NA
		HuEx-1_0	NA
		HuGeneFL	NA
	Agilent	Human 1A Oligo Microarray:PGID215	NA
		Whole Human Genome Oligo Microarray:PGID247	NA
Related H-InvDB links			H-ANGEL;  DNAProbeLocator;

Disease/pathology information

Last modified:27-May-2015

Disease relation		Disease name:NA
Related information in OMIM		OMIM ID:  164690;  Title: V-ABL ABELSON MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 2
Co-localized orphan diseases		NA
Disease related mutation		NA
Literature-Extracted GENe-Disease Associations (LEGENDA)	Gene name	Entrez Gene ID:(27)
	Disease	Entrez Gene ID:(27)
	Substance	Entrez Gene ID:(27)
Related H-InvDB links		DiseaseInfo Viewer;  LEGENDA;

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 34 .. 34 T/C rs200931513 - CDS Synonymous[Leu3Leu] 37 .. 37 G/A rs200959542 - CDS Synonymous[Gly4Gly] 60 .. 60 G/C rs1318056 - CDS Nonsynonymous[Ser12Thr] 92 .. 92 T/A rs201683367 - CDS Nonsynonymous[Cys23Ser] 95 .. 95 C/A rs202125612 - CDS Nonsynonymous[Leu24Met] 150 .. 150 G/A rs55655202 - CDS Nonsynonymous[Arg42His] 156 .. 156 A/G rs140935116 - CDS Nonsynonymous[Tyr44Cys] 209 .. 209 A/G rs201376490 - CDS Nonsynonymous[Lys62Glu] 223 .. 223 C/T rs200064313 - CDS Synonymous[Leu66Leu] 224 .. 224 G/A rs187540054 - CDS Nonsynonymous[Gly67Arg] 253 .. 253 C/T rs200298102 - CDS Synonymous[Phe76Phe] 254 .. 254 G/A rs201168871 - CDS Nonsynonymous[Val77Ile] 297 .. 297 G/A rs147306941 - CDS Nonsynonymous[Ser91Asn] 363 .. 363 G/A rs148596386 - CDS Nonsynonymous[Arg113His] 381 .. 381 G/T rs61821670 - CDS Nonsynonymous[Gly119Val] 426 ^ 427 -/A rs35945588 - CDS 461 .. 461 G/A rs149352120 - CDS Nonsynonymous[Ala146Thr] 567 .. 567 T/C rs112007604 - CDS Nonsynonymous[Val181Ala] 568 .. 568 G/A rs28914528 + CDS Synonymous[Val181Val] 793 .. 793 C/T rs180770623 - CDS Synonymous[His256His] 805 .. 805 C/T rs201235188 - CDS Synonymous[Gly260Gly] 826 .. 826 C/T rs56032037 - CDS Synonymous[Tyr267Tyr] 833 .. 833 G/A rs200847097 - CDS Nonsynonymous[Val270Ile] 856 .. 856 A/G rs28914532 + CDS Synonymous[Thr277Thr] 872 .. 872 T/C rs28914533 + CDS Synonymous[Leu283Leu] 930 .. 930 A/G rs192943572 - CDS Nonsynonymous[Glu302Gly] 949 .. 949 G/A rs143159520 - CDS Synonymous[Leu308Leu] 987 .. 987 T/G rs147552979 - CDS Nonsynonymous[Phe321Cys] 1000 .. 1000 T/G rs150181582 - CDS Synonymous[Thr325Thr] 1003 .. 1003 A/G rs139334603 - CDS Synonymous[Glu326Glu] 1023 .. 1023 T/A rs141559171 - CDS AA-STOP[Leu333*] 1057 .. 1057 G/A rs199688019 - CDS Synonymous[Glu344Glu] 1087 .. 1087 C/T rs201521779 - CDS Synonymous[Ala354Ala] 1214 .. 1214 T/C rs140036159 - CDS Synonymous[Leu397Leu] 1234 .. 1234 T/C rs142746259 - CDS Synonymous[Tyr403Tyr] 1319 .. 1319 G/A rs144729350 - CDS Nonsynonymous[Val432Ile] 1348 .. 1348 T/C rs74388525 - CDS Synonymous[Phe441Phe] 1349 .. 1349 C/T rs76040121 - CDS Synonymous[Leu442Leu] 1360 .. 1360 T/A rs78629915 - CDS Nonsynonymous[Phe445Leu] 1365 .. 1365 T/A rs139017377 - CDS Nonsynonymous[Phe447Tyr] 1371 ^ 1372 -/T rs56346584 - CDS 1406 .. 1406 G/A rs191517026 - 3'UTR 1465 .. 1465 G/A rs146191539 - 3'UTR 1475 .. 1475 T/G rs186481839 - 3'UTR 1547 .. 1547 G/A rs144505173 - 3'UTR 1571 .. 1571 A/G rs181244513 - 3'UTR 1576 .. 1576 T/G rs115703163 - 3'UTR 1588 .. 1588 G/A rs188314277 - 3'UTR 1672 .. 1672 C/T rs183613361 - 3'UTR 1762 .. 1762 G/A rs181902372 - 3'UTR 1765 .. 1765 C/A rs61821668 - 3'UTR  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  Type Start End Strand L2a 1443 1503 - AluSz 1523 1833 + Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;