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H-Invitational ID: HIT000388981 Accession number: BC126389 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: U3 small nucleolar ribonucleoprotein protein MPP10; M phase phosphoprotein 10;
 
 

Transcript original information
Accession number BC126389.1
CAGE tag ID NA
EST ID NA
Clone Number MGC:161667 IMAGE:8992105
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (MPHOSPH10) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (MPHOSPH10);
Sequence data provider NA
Annotation project NA
Length of cDNA 2397[bp] (No. of exon:11)[A:874 T:541 G:582 C:400]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type Brain, cerebellum, PCR rescued clones
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) TAGGAG; 
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0002149
Genomic location  G-integra Help Chromosome 2
Location 2p13.3
Position 71357507- 71377207
Strand +
Possible duplicated location(s) NA
Gene structure 11 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:10199
KEGG GENES KEGG GENES(10199)
GeneCard GeneCardMPHOSPH10*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000031519
Predicted CDS 290..2335;  681[aa];  Orientation:+2; 
Codon Adaptation Index (CAI). 0.71
Database links RefSeq NP_005782
UniProt O00566
CCDS CCDS1916

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000388981
H-Inv cluster ID Locus viewHIX0002149
Accession number BC126389.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help Representative H-Inv IDRepresentative transcript; 
Coding potential  Help Protein coding; 
Definition U3 small nucleolar ribonucleoprotein protein MPP10; M phase phosphoprotein 10;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (O00566)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 88852399450966124298491265500415489334170819831866964819608861196903322006823121406692ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol MPHOSPH10
HGNC aliases NA
HGNC name M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
DDBJ MPHOSPH10
UniProt MPHOSPH10
EC number NA
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000031519
No. of interaction 2
Interaction partner(s) HIP000028058HIP000033751
BIND 150672; 
DIP NA
MINT MINT-62204; 
HPRD 10002;  12664; 
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:10199
KEGG GENES KEGG GENES(10199)
GeneCard GeneCardMPHOSPH10*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Human curated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA


Subcellular localization information  Last modified:27-May-2015
WoLF PSORT nuclear;  cytosol;  mitochondria;  Other; 
Target P Not predicted
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
407 515 1otvA 3e-04 21.4 98/100 a.132.1.4
Related H-InvDB links GTOP GTOP

Evolutionary information  Evola Help Last modified:27-May-2015
Relationship Species Accession number MGI Links
Orthology Mus sp. (Mouse) BC049270 MGI:1915223 G-integraG-integra
Orthology Bos sp. (Cow) BC112826 G-integraG-integra
Orthology Equus sp. (Horse) ENSECAT00000006174 G-integraG-integra
Orthology Gallus sp. (Chicken) ENSGALT00000006206 G-integraG-integra
Orthology Oryzias sp. (Medaka) ENSORLT00000007348 G-integraG-integra
Orthology Pongo sp. (Orangutan) ENSPPYT00000014287 G-integraG-integra
Orthology Takifugu sp. (Fugu) SINFRUT00000151377 G-integraG-integra
Orthology Rattus sp. (Rat) XM_001058593 G-integraG-integra
Orthology Macaca sp. (Macaque) XM_001102757 G-integraG-integra
Orthology Monodelphis sp. (Opossum) XM_001373682 G-integraG-integra
Orthology Pan sp. (Chimpanzee) XM_515539 G-integraG-integra
Orthology Danio sp. (Zebrafish) XM_704562 G-integraG-integra
Orthology Canis sp. (Dog) XM_844258 G-integraG-integra
Phylogenetic tree [View by ATV]
Neighbor-joining (phb) 
Related H-InvDB links EvolaEvoladN/dS (under constraction); 

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
128 .. 128 T/C rs1813348 - 5'UTR
154 .. 154 G/- rs35711199 + 5'UTR
204 .. 204 G/C rs981947 - 5'UTR
258 .. 258 A/G rs10189836 + 5'UTR
301 .. 301 G/A rs78215199 + CDS Synonymous[Gln4Gln]
316 .. 316 G/T rs138844543 + CDS Synonymous[Arg9Arg]
318 .. 318 C/T rs148096202 + CDS Nonsynonymous[Thr10Ile]
378 .. 378 C/A rs80028181 + CDS Nonsynonymous[Thr30Lys]
393 .. 393 T/C rs200571251 + CDS Nonsynonymous[Leu35Ser]
411 .. 411 C/A rs138723053 + CDS Nonsynonymous[Ser41Tyr]
451 .. 451 G/A rs72905506 + CDS Synonymous[Glu54Glu]
453 .. 453 A/G rs147197385 + CDS Nonsynonymous[Asn55Ser]
462 ^ 463 -/G rs34356117 + CDS
495 .. 495 A/C rs10199088 + CDS Nonsynonymous[Glu69Ala]
514 .. 514 G/C rs148413056 + CDS Nonsynonymous[Gln75His]
546 .. 546 C/T rs201101221 + CDS Nonsynonymous[Pro86Leu]
576 .. 576 G/A rs146622063 + CDS Nonsynonymous[Ser96Asn]
601 .. 601 C/T rs147378618 + CDS Synonymous[Ile104Ile]
632 .. 632 C/T rs141436611 + CDS Nonsynonymous[Arg115Cys]
633 .. 633 G/A rs13010513 + CDS Nonsynonymous[Arg115His]
697 ^ 698 -/G rs35780088 + CDS
707 .. 707 G/A rs10175940 + CDS Nonsynonymous[Asp140Asn]
725 ^ 726 -/C rs34204128 + CDS
743 .. 743 G/A rs76790487 + CDS Nonsynonymous[Ala152Thr]
750 .. 750 A/G rs76328738 + CDS Nonsynonymous[Asn154Ser]
769 .. 769 G/A rs115136870 + CDS Synonymous[Leu160Leu]
781 .. 781 C/T rs148255112 + CDS Synonymous[Pro164Pro]
782 .. 782 G/A rs150757204 + CDS Nonsynonymous[Val165Ile]
787 .. 787 C/T rs185887303 + CDS Synonymous[Phe166Phe]
866 .. 866 A/C rs142307654 + CDS Nonsynonymous[Lys193Gln]
872 .. 872 A/G rs201807098 + CDS Nonsynonymous[Arg195Gly]
876 .. 876 A/T rs140167417 + CDS Nonsynonymous[Glu196Val]
966 .. 966 A/T rs145808867 + CDS Nonsynonymous[Asp226Val]
976 .. 976 G/T rs1813160 - CDS Nonsynonymous[Glu229Asp]
987 .. 987 A/G rs146320449 + CDS Nonsynonymous[Asp233Gly]
990 .. 990 T/C rs146238687 + CDS Nonsynonymous[Ile234Thr]
1008 .. 1008 T/C rs147378452 + CDS Nonsynonymous[Ile240Thr]
1064 .. 1064 A/- rs34427467 + CDS
1073 .. 1073 A/G rs200840206 + CDS Nonsynonymous[Arg262Gly]
1136 .. 1136 C/G rs143555311 + CDS Nonsynonymous[His283Asp]
1141 .. 1141 T/G rs138051249 + CDS Nonsynonymous[Asp284Glu]
1160 .. 1160 A/G rs139834642 + CDS Nonsynonymous[Lys291Glu]
1203 .. 1203 G/A rs139416675 + CDS Nonsynonymous[Ser305Asn]
1215 .. 1215 C/T rs150027370 + CDS Nonsynonymous[Thr309Met]
1267 .. 1267 A/T rs140795709 + CDS Nonsynonymous[Glu326Asp]
1284 .. 1284 C/G rs147873518 + CDS Nonsynonymous[Thr332Ser]
1364 .. 1364 T/G rs144162265 + CDS Nonsynonymous[Ser359Ala]
1405 .. 1405 A/T rs143656591 + CDS Synonymous[Ala372Ala]
1444 .. 1444 G/A rs357756 - CDS Synonymous[Gln385Gln]
1466 .. 1466 C/T rs185323253 + CDS AA-STOP[Gln393*]
1543 .. 1543 A/G rs142446927 + CDS Synonymous[Thr418Thr]
1562 .. 1562 C/A rs3732240 - CDS Nonsynonymous[Leu425Met]
1572 .. 1572 T/C rs144451311 + CDS Nonsynonymous[Ile428Thr]
1617 .. 1617 G/C rs201469945 + CDS Nonsynonymous[Arg443Pro]
1644 .. 1644 A/G rs201345050 + CDS Nonsynonymous[Tyr452Cys]
1652 ^ 1653 -/A rs35234991 + CDS
1659 .. 1659 G/A rs150663819 + CDS Nonsynonymous[Arg457His]
1732 .. 1732 C/T rs200379927 + CDS Synonymous[Asn481Asn]
1800 .. 1800 T/G rs184076603 + CDS Nonsynonymous[Phe504Cys]
1814 .. 1814 G/A rs201442097 + CDS Nonsynonymous[Ala509Thr]
1818 .. 1818 T/C rs113020560 + CDS Nonsynonymous[Leu510Pro]
1825 .. 1825 C/T rs150121309 + CDS Synonymous[Asn512Asn]
1836 .. 1836 T/A rs147470609 + CDS Nonsynonymous[Ile516Asn]
1838 .. 1838 C/G rs201817555 + CDS Nonsynonymous[Pro517Ala]
1846 .. 1846 G/A rs149974821 + CDS Synonymous[Pro519Pro]
1913 .. 1913 A/G rs142733900 + CDS Nonsynonymous[Ser542Gly]
1925 .. 1925 G/A rs146484955 + CDS Nonsynonymous[Ala546Thr]
1929 .. 1929 C/T rs144785864 + CDS Nonsynonymous[Ala547Val]
1931 .. 1931 C/A rs200064442 + CDS Nonsynonymous[Leu548Ile]
1942 .. 1942 A/G rs150290774 + CDS Synonymous[Pro551Pro]
1975 .. 1975 T/C rs137939950 + CDS Synonymous[Asp562Asp]
2073 .. 2073 G/A rs115361918 + CDS Nonsynonymous[Arg595Gln]
2092 .. 2092 G/C rs201478815 + CDS Nonsynonymous[Lys601Asn]
2155 .. 2155 G/A rs147514745 + CDS Synonymous[Leu622Leu]
2158 .. 2158 C/T rs139610173 + CDS Synonymous[Thr623Thr]
2167 .. 2167 C/G rs139947933 + CDS Synonymous[Gly626Gly]
2170 .. 2170 A/C rs150611026 + CDS Nonsynonymous[Lys627Asn]
2189 .. 2189 G/A rs6574 - CDS Nonsynonymous[Glu634Lys]
2204 .. 2204 G/A rs4852764 + CDS Nonsynonymous[Ala639Thr]
2222 .. 2222 G/A rs79381339 + CDS Nonsynonymous[Ala645Thr]
2259 .. 2259 A/G rs199933584 + CDS Nonsynonymous[Gln657Arg]
2282 .. 2282 G/A rs146734138 + CDS Nonsynonymous[Glu665Lys]
2287 .. 2287 G/A rs147981393 + CDS Synonymous[Lys666Lys]
2322 .. 2322 A/G rs201031250 + CDS Nonsynonymous[Lys678Arg]
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer