H-InvDB x AHG DB
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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000390003 Accession number: BC129930 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Similar to Chaperone activity of bc1 complex-like, mitochondrial; Chaperone-ABC1-like; EC=2.7.11.-; aarF domain-containing protein kinase 3; Precursor;
 
 

Transcript original information
Accession number BC129930.1
CAGE tag ID NA
EST ID NA
Clone Number MGC:156124 IMAGE:40010265
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (ADCK3) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (ADCK3);
Sequence data provider NA
Annotation project NA
Length of cDNA 2288[bp] (No. of exon:16)[A:463 T:450 G:698 C:677]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type PCR rescued clones
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) AAGGAG; 
Transcript quality feature Truncation; 
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0001648
Genomic location  G-integra Help Chromosome 1
Location 1q42.13
Position 227087135- 227171556
Strand +
Possible duplicated location(s) NA
Gene structure 16 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:56997
KEGG GENES KEGG GENES(56997)
GeneCard GeneCardADCK3*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000176725
Predicted CDS 1015..2247;  410[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.846

Motif information
ORF

length(410),orf(1015:2247)
MAAILGDTIMVAKGLVKLTQAAVETHLQHLGIGGELIMAARALQSTAVEQ
IGMFLGKVQGQDKHEEYFAENFGGPEGEFHFSVPHAAGASTDFSSASAPD
QSAPPSLGHAHSEGPAPAYVASGPFREAGFPGQASSPLGRANGRLFANPR
DSFSAMGFQRRFFHQDQSPVGGLTAEDIEKARQAKARPENKQHKQTLSEH
ARERKVPVTRIGRLANFGGLAVGLGFGALAEVAKKSLRSEDPSGKKAVLG
SSPFLSEANAERIVRTLCKVRGAALKLGQMLSIQDDAFINPHLAKIFERV
RQSADFMPLKQMMKTLNNDLGPNWRDKLEYFEERPFAAASIGQVHLARMK
GGREVAMKIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRR
ELALECDYQR*
a.a.
length
InterPro Name
length(92), motif(319:410) 92 IPR004147 UbiB domain [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000390003
H-Inv cluster ID Locus viewHIX0001648
Accession number BC129930.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO; 
Coding potential  Help Protein coding; 
Definition Similar to Chaperone activity of bc1 complex-like, mitochondrial; Chaperone-ABC1-like; EC=2.7.11.-; aarF domain-containing protein kinase 3; Precursor;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (Q8NI60)  [Identity/coverage = 99.286%/64.91%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 11888884147020391548933415498874167104141734484617974005183190721831907421269460ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol ADCK3
HGNC aliases "chaperone-ABC1 (activity of bc1 complex, S.pombe)-like", "chaperone, ABC1 activity of bc1 complex like (S. pombe)", "chaperone, ABC1 activity of bc1 complex homolog (S. pombe)"
HGNC name aarF domain containing kinase 3
DDBJ CABC1
UniProt ADCK3
EC number EC 2.7.11.-Protein-serine/threonine kinases; 
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000176725
No. of interaction 1
Interaction partner(s) HIP000162479
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:56997
KEGG GENES KEGG GENES(56997)
GeneCard GeneCardADCK3*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
FR ID FR306988
Accession
Description
Location
PMID


Subcellular localization information  Last modified:27-May-2015
WoLF PSORT mitochondria;  cytosol;  nuclear;  Other; 
Target P Not predicted
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
267 323 1y74A1 1e-20 17.5 57/57 a.194.1.1
315 397 1zylA1 7e-06 12.0 83/325 d.144.1.6
Related H-InvDB links GTOP GTOP

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
42 .. 42 A/G rs183482270 + 5'UTR
48 .. 48 C/T rs186320033 + 5'UTR
128 .. 128 T/G rs16846644 + 5'UTR
203 .. 203 G/C rs180736874 + 5'UTR
307 .. 307 C/A rs138360609 + 5'UTR
308 .. 308 G/A rs12035060 + 5'UTR
363 .. 363 C/T rs149324253 + 5'UTR
403 .. 403 C/T rs182779372 + 5'UTR
404 .. 404 G/A rs187692774 + 5'UTR
466 .. 466 G/A rs193250427 + 5'UTR
548 .. 548 A/T rs72758693 + 5'UTR
570 .. 570 C/T rs145529997 + 5'UTR
612 .. 612 T/C rs185383882 + 5'UTR
625 .. 625 G/A rs113452228 + 5'UTR
637 .. 637 C/T rs189414759 + 5'UTR
645 .. 645 A/G rs148844221 + 5'UTR
647 .. 647 C/T rs142535232 + 5'UTR
682 .. 682 C/A rs182018909 + 5'UTR
764 .. 764 C/T rs139610210 + 5'UTR
871 .. 871 G/A rs12730465 + 5'UTR
1015 .. 1015 A/G rs199604256 + CDS Nonsynonymous[Met1Val]
1025 .. 1025 T/A rs202075418 + CDS Nonsynonymous[Ile4Lys]
1049 .. 1049 C/T rs200052870 + CDS Nonsynonymous[Ala12Val]
1064 .. 1064 A/G rs150221608 + CDS Nonsynonymous[Lys17Arg]
1076 .. 1076 C/T rs142184584 + CDS Nonsynonymous[Ala21Val]
1077 .. 1077 G/A rs11549709 + CDS Synonymous[Ala21Ala]
1081 .. 1081 G/A rs35582308 + CDS Nonsynonymous[Val23Met]
1092 .. 1092 C/T rs150541057 + CDS Synonymous[His26His]
1110 .. 1110 C/T rs199919057 + CDS Synonymous[Ile32Ile]
1114 .. 1114 G/A rs142125927 + CDS Nonsynonymous[Gly34Arg]
1131 .. 1131 G/A rs11549708 + CDS Synonymous[Ala39Ala]
1151 .. 1151 C/T rs187123516 + CDS Nonsynonymous[Thr46Met]
1185 .. 1185 G/C rs200123840 + CDS Nonsynonymous[Lys57Asn]
1245 .. 1245 G/A rs201037948 + CDS Synonymous[Gly77Gly]
1252 .. 1252 C/T rs76249490 + CDS Nonsynonymous[His80Tyr]
1254 .. 1254 C/T rs113667144 + CDS Synonymous[His80His]
1255 .. 1255 T/C rs200349511 + CDS Nonsynonymous[Phe81Leu]
1269 .. 1269 T/G rs2297411 + CDS Nonsynonymous[His85Gln]
1271 .. 1271 C/T rs150377969 + CDS Nonsynonymous[Ala86Val]
1272 .. 1272 A/C rs137872711 + CDS Synonymous[Ala86Ala]
1273 .. 1273 G/A rs138572539 + CDS Nonsynonymous[Ala87Thr]
1277 .. 1277 G/T rs141687205 + CDS Nonsynonymous[Gly88Val]
1305 .. 1305 C/T rs111529228 + CDS Synonymous[Ser97Ser]
1306 .. 1306 G/T rs200000374 + CDS Nonsynonymous[Ala98Ser]
1312 .. 1312 G/T rs150696959 + CDS Nonsynonymous[Asp100Tyr]
1339 .. 1339 C/G rs201479287 + CDS Nonsynonymous[His109Asp]
1349 .. 1349 G/A rs147889685 + CDS Nonsynonymous[Ser112Asn]
1398 .. 1398 C/T rs139970507 + CDS Synonymous[Ala128Ala]
1416 .. 1416 C/T rs200182503 + CDS Synonymous[Ala134Ala]
1481 .. 1481 T/C rs147812454 + CDS Nonsynonymous[Met156Thr]
1486 .. 1486 T/C rs142652509 + CDS Nonsynonymous[Phe158Leu]
1535 .. 1535 C/A rs181579601 + CDS Nonsynonymous[Thr174Lys]
1539 .. 1539 C/T rs201787750 + CDS Synonymous[Ala175Ala]
1578 .. 1578 C/T rs140897240 + CDS Synonymous[Pro188Pro]
1601 .. 1601 C/T rs200762439 + CDS Nonsynonymous[Thr196Met]
1608 .. 1608 C/T rs138547552 + CDS Synonymous[Ser198Ser]
1615 .. 1615 G/T rs188599627 + CDS Nonsynonymous[Ala201Ser]
1619 .. 1619 G/A rs145350362 + CDS Nonsynonymous[Arg202Gln]
1625 .. 1625 G/A rs200541514 + CDS Nonsynonymous[Arg204Gln]
1632 .. 1632 G/A rs115855910 + CDS Synonymous[Val206Val]
1651 .. 1651 C/T rs119468005 + CDS Nonsynonymous[Arg213Trp]
1693 .. 1693 G/A rs199694417 + CDS Nonsynonymous[Gly227Arg]
1737 .. 1737 C/- rs35757883 + CDS
1744 .. 1744 G/C rs199619932 + CDS Nonsynonymous[Gly244Arg]
1756 .. 1756 G/A rs148376283 + CDS Nonsynonymous[Val248Met]
1759 .. 1759 C/T rs199958142 + CDS Synonymous[Leu249Leu]
1794 .. 1794 A/G rs147447166 + CDS Synonymous[Ala260Ala]
1799 .. 1799 G/A rs145422777 + CDS Nonsynonymous[Arg262Gln]
1808 .. 1808 G/A rs199696414 + CDS Nonsynonymous[Arg265His]
1811 .. 1811 C/T rs149924675 + CDS Nonsynonymous[Thr266Met]
1825 .. 1825 C/T rs145034527 + CDS Nonsynonymous[Arg271Cys]
1829 .. 1829 G/A/T rs119468006 + CDS
1868 .. 1868 A/C rs143493998 + CDS Nonsynonymous[Asp285Ala]
1887 .. 1887 C/T rs200849486 + CDS Synonymous[Pro291Pro]
1890 .. 1890 C/G rs200155917 + CDS Nonsynonymous[His292Gln]
1905 .. 1905 C/T rs55968053 + CDS Synonymous[Phe297Phe]
1909 .. 1909 C/T rs201908721 + CDS Nonsynonymous[Arg299Trp]
1915 .. 1915 C/T rs140246430 + CDS Nonsynonymous[Arg301Trp]
1923 .. 1923 C/T rs202036077 + CDS Synonymous[Ser303Ser]
1962 .. 1962 C/T rs55637780 + CDS Synonymous[Leu316Leu]
2003 .. 2003 A/G rs150243147 + CDS Nonsynonymous[Tyr330Cys]
2005 .. 2005 T/C rs201334858 + CDS Nonsynonymous[Phe331Leu]
2007 .. 2007 C/T rs41303129 + CDS Synonymous[Phe331Phe]
2023 .. 2023 G/A rs143816043 + CDS Nonsynonymous[Ala337Thr]
2025 .. 2025 C/T rs36006006 + CDS Synonymous[Ala337Ala]
2034 .. 2034 C/T rs181558991 + CDS Synonymous[Ser340Ser]
2036 .. 2036 T/C rs55798516 + CDS Nonsynonymous[Ile341Thr]
2067 .. 2067 C/T rs55958233 + CDS Synonymous[Gly351Gly]
2103 .. 2103 C/T rs139570869 + CDS Synonymous[Gly363Gly]
2122 .. 2122 A/G rs180784380 + CDS Nonsynonymous[Ser370Gly]
2134 .. 2134 A/C rs146751657 + CDS Nonsynonymous[Asn374His]
2199 .. 2199 C/T rs17849927 + CDS Synonymous[Ile395Ile]
2202 .. 2202 C/T rs139133094 + CDS Synonymous[Asp396Asp]
2207 .. 2207 T/C rs199921339 + CDS Nonsynonymous[Leu398Pro]
2229 .. 2229 G/A rs149048093 + CDS Synonymous[Glu405Glu]
2260 .. 2260 C/T rs151292389 + 3'UTR
2265 .. 2265 G/A rs202227926 + 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
Type Start End Strand
SVA_A 303 515 +
AluSx 516 538 -
AluSq2 565 669 -
AluSx 700 822 -
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer