H-InvDB x AHG DB
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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000390579 Accession number: BC131617 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Similar to Bone morphogenetic protein 8A precursor.
 
 

Transcript original information
Accession number BC131617.1
CAGE tag ID NA
EST ID NA
Clone Number MGC:149599 IMAGE:40116584
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ;
Sequence data provider NA
Annotation project NA
Length of cDNA 996[bp] (No. of exon:6)[A:197 T:184 G:285 C:330]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type PCR rescued clones
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature Truncation; 
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0213899
Genomic location  G-integra Help Chromosome 1
Location 1p34.3
Position 39976876- 39991595
Strand +
Possible duplicated location(s) NA
Gene structure 6 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:353500
KEGG GENES KEGG GENES(353500)
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000241681
Predicted CDS 155..871;  238[aa];  Orientation:+2; 
Codon Adaptation Index (CAI). 0.835

Motif information
ORF

length(238),orf(155:871)
MFQVVQEQSNRESDLFFLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDL
GLRLYVETEDGHSVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPRA
VRPLRRRQPKKTNELPQANRLPGIFDDVHGSHGRQVCRRHELYVSFQDLG
WLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMKPNAVPK
ACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH*
a.a.
length
InterPro Name
length(238), motif(1:238) 238 IPR015615 Transforming growth factor-beta-related [Family]
length(86), motif(2:87) 86 IPR001111 Transforming growth factor-beta, N-terminal [Domain]
length(18), motif(90:107) 18 IPR002405 Inhibin, alpha subunit [Family]
length(135), motif(104:238) 135 IPR001839 Transforming growth factor-beta, C-terminal [Domain]
length(109), motif(129:237) 109 IPR029034 Cystine-knot cytokine [Domain]
length(108), motif(131:238) 108 IPR029034 Cystine-knot cytokine [Domain]
length(104), motif(135:238) 104 IPR001839 Transforming growth factor-beta, C-terminal [Domain]
length(18), motif(137:154) 18 IPR002405 Inhibin, alpha subunit [Family]
length(102), motif(137:238) 102 IPR001839 Transforming growth factor-beta, C-terminal [Domain]
length(18), motif(154:171) 18 IPR002405 Inhibin, alpha subunit [Family]
length(16), motif(155:170) 16 IPR017948 Transforming growth factor beta, conserved site [Conserved_site]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000390579
H-Inv cluster ID Locus viewHIX0213899
Accession number BC131617.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO; 
Coding potential  Help Protein coding; 
Definition Similar to Bone morphogenetic protein 8A precursor.
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (NP_861525)  [Identity/coverage = 97.917%/71.64%] to Homo sapiens protein.
Experimental evidence Protein evidence
PubMed ID NA
Gene family/group Gene family H-Inv gene family/group ID HIF0000072
Gene family/group name Transforming growth factor-beta-related (IPR015615).
Evidence motif (InterPro) ID 3
Gene symbol/name HGNC symbol NA
HGNC aliases NA
HGNC name NA
DDBJ BMP8A
UniProt NA
EC number NA
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000241681
No. of interaction NA
Interaction partner(s) NA
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:353500
KEGG GENES KEGG GENES(353500)
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Transforming growth factor-beta-related (IPR015615). Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function growth factor activity (GO:0008083); 
Biological process growth (GO:0040007); 
Cellular component extracellular region (GO:0005576); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT nuclear;  cytosol;  extracellular;  Other; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
135 238 1bmpA 9e-41 73.1 104/104 g.17.1.2
Related H-InvDB links GTOP GTOP

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
81 .. 81 C/T rs201515760 + 5'UTR
81 .. 81 C/T rs1737739 + 5'UTR
125 .. 125 C/T rs202230393 + 5'UTR
125 .. 125 C/T rs1737740 + 5'UTR
148 .. 148 C/T rs201346829 + 5'UTR
274 .. 274 C/G rs113283888 + CDS Nonsynonymous[Asp40Glu]
275 .. 275 T/A rs112495864 + CDS Nonsynonymous[Cys41Ser]
290 .. 290 C/T rs199515004 + CDS Nonsynonymous[Arg46Cys]
334 .. 334 T/C rs200415763 + CDS Synonymous[Asp60Asp]
334 .. 334 T/C rs6526 + CDS Synonymous[Asp60Asp]
440 .. 440 C/T rs199572402 + CDS Nonsynonymous[Arg96Cys]
471 .. 471 G/A rs139271312 + CDS Nonsynonymous[Arg106Lys]
478 .. 478 G/A rs115627781 + CDS Synonymous[Gln108Gln]
478 .. 478 G/A rs704788 + CDS Synonymous[Gln108Gln]
481 .. 481 G/T rs138799498 + CDS Synonymous[Pro109Pro]
489 .. 489 C/G rs144103941 + CDS Nonsynonymous[Thr112Ser]
489 .. 489 C/G rs179472 - CDS Nonsynonymous[Thr112Ser]
494 .. 494 G/A rs142499129 + CDS Nonsynonymous[Glu114Lys]
540 .. 540 A/G rs6525 + CDS Nonsynonymous[His129Arg]
540 .. 540 A/G rs17403490 + CDS Nonsynonymous[His129Arg]
551 .. 551 G/A rs139522712 + CDS Nonsynonymous[Gly133Ser]
555 .. 555 G/A rs146607525 + CDS Nonsynonymous[Arg134Gln]
569 .. 569 C/T rs201171133 + CDS Nonsynonymous[Arg139Trp]
582 .. 582 A/C rs143938877 + CDS Nonsynonymous[Tyr143Ser]
584 .. 584 G/A rs148937049 + CDS Nonsynonymous[Val144Ile]
601 .. 601 T/C rs6524 + CDS Synonymous[Leu149Leu]
640 .. 640 A/G rs2889739 + CDS Synonymous[Ser162Ser]
673 .. 673 G/A rs2377809 + CDS Synonymous[Pro173Pro]
691 .. 691 C/T rs2889740 + CDS Synonymous[Asn179Asn]
740 .. 740 A/G rs149527255 + CDS Nonsynonymous[Asn196Asp]
742 .. 742 C/T rs148598959 + CDS Synonymous[Asn196Asn]
743 .. 743 G/A rs146209962 + CDS Nonsynonymous[Ala197Thr]
754 .. 754 G/- rs35084347 + CDS
786 .. 786 C/T rs143780116 + CDS Nonsynonymous[Thr211Ile]
817 .. 817 C/T rs140621133 + CDS Synonymous[Asn221Asn]
828 .. 828 G/A rs149302123 + CDS Nonsynonymous[Arg225His]
837 .. 837 G/A rs201221908 + CDS Nonsynonymous[Arg228His]
874 .. 875 CA/AG rs35048605 + 3'UTR
875 .. 875 A/C rs11583829 + 3'UTR
876 .. 876 G/A rs2230006 + 3'UTR
884 .. 884 A/G rs2230007 + 3'UTR
889 .. 889 T/A rs199639169 + 3'UTR
890 .. 890 A/G rs200751474 + 3'UTR
952 .. 952 C/T rs185084410 + 3'UTR
977 .. 977 G/A rs148429650 + 3'UTR
989 .. 989 G/T rs3738676 + 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer