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H-Invitational ID: HIT000393075 Accession number: DQ655962 Created date: 26-Mar-2013 Last modified: 27-May-2015 Definition: Similar to Cyclin-dependent kinase 14.

		Select format Flat file XML file Nucleotide sequence fasta Protein sequence fasta

Transcript original information Accession number DQ655962.2 CAGE tag ID NA EST ID NA Clone Number UGL15a02 Experimental resources   NBRC ; HGPD ; Antibody (CLDN12) ; Catalog (CLDN12); Sequence data provider NA Annotation project NA Length of cDNA 567[bp] (No. of exon:6)[A:189 T:130 G:140 C:108] Devision HTC Molecular type mRNA Library origin Cell type NA Tissue type NA Develpmental stage NA

Sequence quality information CDS feature C-truncated Kozak sequence NA PolyA NA Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) NA Transcript quality feature Truncation;  Notes NA

TTTCAGGGCTGTTGCTCCTGACAGATAAGTCAGTCTACCTGTTGTTGAAT GACATGCAGAAAAGAAATTTGGTAAGAAGAAAGTGATTTGACTTTGAAGA AAGATGACACCACCTTTGATGAGCTTTGATGATTGCCAGAACAAAGTGTT GGCTCTGCCTGGCTCTTTGATATGTGTCACAAAGATGTCTACACGGAACT GCCAGGGAATGGACTCAGTGATCAAACCCCTGGACACAATTCCTGAGGAT AAAAAAGTCAGAGTTCAGAGGACACAGAGCACTTTTGACCCATTTGAGAA ACCAGCTAATCAAGTAAAGAGGGTGCATTCTGAGAACAATGCTTGCATTA ACTTTAAGACCTCCTCCACTGGCAAAGAGTCACCTAAAGTTAGGCGGCAC TCCAGCCCCAGCTCGTCAACAAGTCCCAAATTTGGAAAAGCTGACTCATA TGAAAAGCTGGAAAAACTAGGGGAAGGATCTTATGCTACAGTATACAAAG GGAAAAGCAAGGTAAATGGGAAGTTGGTAGCTCTGAAGGTGATCAGGCTG CAGGAAGAAGAAGGGAA

Gene structure information

H-Inv cluster ID		HIX0006831
Genomic location	Chromosome	7
	Location	7q21.13
	Position	90193088- 90419943
	Strand	+
Possible duplicated location(s)		NA
Gene structure		6 exon(s)
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:5218;
	KEGG GENES	KEGG GENES(5218);
	GeneCard	CLDN12;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000191070 Predicted CDS 104..567;  154[aa];  Orientation:+2;  Codon Adaptation Index (CAI). 0.773

MTPPLMSFDDCQNKVLALPGSLICVTKMSTRNCQGMDSVIKPLDTIPEDK KVRVQRTQSTFDPFEKPANQVKRVHSENNACINFKTSSTGKESPKVRRHS SPSSSTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQ EEEG

Motif information

	a.a. length	InterPro	Name
	57	IPR011009	Protein kinase-like domain [Domain]
	37	IPR000719	Protein kinase domain [Domain]
	39	IPR000719	Protein kinase domain [Domain]
	24	IPR017441	Protein kinase, ATP binding site [Binding_site]

Gene function information

H-Inv ID		HIT000393075
H-Inv cluster ID		HIX0006831
Accession number		DQ655962.2
CAGE tag ID		NA
EST ID		NA
Transcript feature		NO;
Coding potential		Protein coding;
Definition		Similar to Cyclin-dependent kinase 14.
Similarity category		Category: Similar to known protein(Category II).
		Similar to known protein (NP_036527)  [Identity/coverage = 98.485%/29.27%] to Homo sapiens protein.
Experimental evidence		Protein evidence
PubMed ID		NA
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	CLDN12
	HGNC aliases	NA
	HGNC name	claudin 12
	DDBJ	NA
	UniProt	NA
EC number		EC 2.7.11.22cyclin-dependent kinase;
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		04360 :Axon guidance;  04530 :Tight junction;  04540 :Gap junction;  04660 :T cell receptor signaling pathway;
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000191070
	No. of interaction	NA
	Interaction partner(s)	NA
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	NA
	IntAct	NA
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:5218;
	KEGG GENES	KEGG GENES(5218);
	GeneCard	CLDN12;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Auto-annotated
Notes		NA
Related H-InvDB links		Gene family;  Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Molecular function	transferase activity, transferring phosphorus-containing groups (GO:0016772);  ATP binding (GO:0005524);  protein kinase activity (GO:0004672);
Biological process	protein amino acid phosphorylation (GO:0006468);

Subcellular localization information

Last modified:27-May-2015

WoLF PSORT	extracellular;  nuclear;  cytosol;
Target P	Other
SOSUI	soluble protein
TMHMM	soluble protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 11 .. 11 G/T rs184316199 + 5'UTR 95 .. 95 T/G rs192282583 + 5'UTR 113 .. 113 C/G rs17866277 + CDS Nonsynonymous[Pro4Ala] 195 .. 195 G/A rs140679817 + CDS Nonsynonymous[Arg31Gln] 229 .. 229 C/T rs144891494 + CDS Synonymous[Pro42Pro] 399 .. 399 A/G rs187133761 + CDS Nonsynonymous[His99Arg] 405 .. 405 G/A rs138436598 + CDS Nonsynonymous[Ser101Asn] 415 .. 415 G/A rs55722725 + CDS Synonymous[Ser104Ser] 489 .. 489 C/T rs148988868 + CDS Nonsynonymous[Thr129Ile] 493 .. 493 A/G rs145790847 + CDS Synonymous[Val130Val] 502 .. 502 G/A rs200795779 + CDS Synonymous[Gly133Gly] 565 .. 565 G/A rs138497570 + CDS Synonymous[Gly154Gly]  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  No data available Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;