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H-Invitational ID: HIT000422579 Accession number: AK289782 Created date: 26-Mar-2013 Last modified: 27-May-2015 Definition: Similar to Cyclin-dependent kinase 14.

		Select format Flat file XML file Nucleotide sequence fasta Protein sequence fasta

Transcript original information Accession number AK289782.1 CAGE tag ID NA EST ID NA Clone Number BRAWH3024113 Experimental resources   NBRC ; HGPD ; Antibody (CLDN12) ; Catalog (CLDN12); Sequence data provider NA Annotation project NA Length of cDNA 1689[bp] (No. of exon:14)[A:502 T:437 G:375 C:375] Devision HUM Molecular type mRNA Library origin Cell type NA Tissue type brain Develpmental stage NA

Sequence quality information CDS feature Complete CDS Kozak sequence NA PolyA NA Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) NA Transcript quality feature NA Notes NA

ATATGCACGGTTACTTTGGCTGCAATGCTGCTGCAGAGCCCGGTTACTCT GCCTTCGTGGGAACTCCACAGATATGTGTCACAAAGATGTCTACACGGAA CTGCCAGGGAATGGACTCAGTGATCAAACCCCTGGACACAATTCCTGAGG ATAAAAAAGTCAGAGTTCAGAGGACACAGAGCACTTTTGACCCATTTGAG AAACCAGCTAATCAAGTAAAGAGGGTGCATTCTGAGAACAATGCTTGCAT TAACTTTAAGACCTCCTCCACTGGCAAAGAGTCACCTAAAGTTAGGCGGC ACTCCAGCCCCAGCTCGCCAACAAGTCCCAAATTTGGAAAAGCTGACTCA TATGAAAAGCTGGAAAAACTAGGGGAAGGATCTTATGCTACAGTATACAA AGGGAAAAGCAAGGTAAATGGGAAGTTGGTAGCTCTGAAGGTGATCAGGC TGCAGGAAGAAGAAGGGACACCTTTCACAGCTATCAGGGAAGCTTCTCTT TTAAAAGGACTAAAACATGCTAACATAGTGCTACTTCATGACATCATCCA TACCAAGGAGACGCTGACACTTGTGTTTGAATATGTGCACACTGATTTAT GTCAGTACATGGACAAGCACCCTGGGGGGCTGCATCCAGATAATGTGAAG TTGTTTTTATTTCAGTTGCTGCGAGGTCTGTCTTACATCCACCAGCGTTA TATTTTGCACAGAGACCTGAAACCACAGAACCTTCTGATCAGTGACACGG GGGAGTTAAAGCTGGCAGATTTCGGTCTTGCAAGAGCAAAATCCGTCCCT AGCCACACATACTCCAACGAAGTGGTTACCTTGTGGTACAGACCTCCAGA TGTCCTTCTAGGCTCAACAGAATATTCCACCTGCCTTGACATGTGGGGAG TAGGTTGCATCTTTGTTGAAATGATCCAAGGAGTTGCTGCTTTTCCAGGA ATGAAAGACATTCAGGATCAACTTGAACGAATATTTCTGGTTCTTGGAAC ACCAAATGAGGACACATGGCCTGGAGTTCATTCTTTACCACATTTTAAGC CAGAACGCTTTACCCTGTACAGCTCTAAAAACCTTAGACAAGCATGGAAT AAGCTCAGCTATGTGAACCATGCAGAGGACCTGGCCTCCAAGCTCCTACA ATGTTCCCCAAAGAACAGACTGTCGGCACAGGCTGCCTTGAGCCACGAGT ATTTTAGTGACCTGCCGCCACGGCTATGGGAACTCACCGACATGTCTTCT ATTTTTACTGTCCCAAATGTGAGATTGCAACCAGAAGCTGGAGAAAGCAT GCGGGCCTTTGGGAAAAACAATAGTTATGGCAAAAGTCTATCAAACAGCA AGCACTGACAAGCAGCACATTCTCAAGAGCACACAGGATTAAGTTGTCAT CATTCTGGGAAGAAAAAAAAAACATTAATGAAGAGGCCAATAATATGAAG GGAATCATGGATCAGTTTTCTTTCGCTCCCTGTGGTGGATTTCACTTACA AGAAAATTGAAGCTGGCAAGACCCTGTTTTCTCTGCAATTTATTTAAAAC CTTGCACGCATTTGGATACCTTGTGATTTCCAAGAACTACGTGAAGATTA AGCTTTGCTTACTGATACATGGCATGTATTCTTTTCAGTCTTTTGTGTTT GATTTTGTTTGATTTCCCTCTGCAGCACAGCGTCTCTGT

Gene structure information

H-Inv cluster ID		HIX0006831
Genomic location	Chromosome	7
	Location	7q21.13
	Position	90338854- 90836782
	Strand	+
Possible duplicated location(s)		NA
Gene structure		14 exon(s)
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:5218;
	KEGG GENES	KEGG GENES(5218);
	GeneCard	CLDN12;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000062429 Predicted CDS 3..1358;  451[aa];  Orientation:+3;  Codon Adaptation Index (CAI). 0.74 Database links RefSeq NP_036527;  UniProt NA CCDS CCDS5619;

MHGYFGCNAAAEPGYSAFVGTPQICVTKMSTRNCQGMDSVIKPLDTIPED KKVRVQRTQSTFDPFEKPANQVKRVHSENNACINFKTSSTGKESPKVRRH SSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRL QEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLC QYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTG ELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGV GCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKP ERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEY FSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAFGKNNSYGKSLSNSK H*

Motif information

	a.a. length	InterPro	Name
	294	IPR011009	Protein kinase-like domain [Domain]
	285	IPR002290	Serine/threonine/dual specificity protein kinase, catalytic domain [Domain]
	285	IPR000719	Protein kinase domain [Domain]
	24	IPR017441	Protein kinase, ATP binding site [Binding_site]
	13	IPR008271	Serine/threonine-protein kinase, active site [Active_site]

Gene function information

H-Inv ID		HIT000422579
H-Inv cluster ID		HIX0006831
Accession number		AK289782.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		NO;
Coding potential		Protein coding;
Definition		Similar to Cyclin-dependent kinase 14.
Similarity category		Category: Similar to known protein(Category II).
		Similar to known protein (NP_036527)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens protein.
Experimental evidence		Protein evidence
PubMed ID		NA
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	CLDN12
	HGNC aliases	NA
	HGNC name	claudin 12
	DDBJ	NA
	UniProt	NA
EC number		EC 2.7.11.22cyclin-dependent kinase;
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		04360 :Axon guidance;  04530 :Tight junction;  04540 :Gap junction;  04660 :T cell receptor signaling pathway;
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000062429
	No. of interaction	1
	Interaction partner(s)	HIP000022816;
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	00021;  00298;  00452;  00886;  01574;  01822;  03184;  04457;  05457;  06902;  10700;
	IntAct	NA
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:5218;
	KEGG GENES	KEGG GENES(5218);
	GeneCard	CLDN12;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Auto-annotated
Notes		NA
Related H-InvDB links		Gene family;  Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Molecular function	transferase activity, transferring phosphorus-containing groups (GO:0016772);  ATP binding (GO:0005524);  protein kinase activity (GO:0004672);
Biological process	protein amino acid phosphorylation (GO:0006468);

Subcellular localization information

Last modified:27-May-2015

WoLF PSORT	nuclear;  cytosol;
Target P	Other
SOSUI	soluble protein
TMHMM	soluble protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified:27-May-2015

Start End PDB_ID E-value Identity Coverage SCOP_ID 27 405 1nw1A 5e-42 7.8 345/365 d.144.1.8

Related H-InvDB links GTOP

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 9 .. 9 G/A rs200626528 + CDS Nonsynonymous[Gly3Ser] 22 .. 22 G/T rs16867927 + CDS Nonsynonymous[Cys7Phe] 39 .. 39 C/T rs200101624 + CDS Nonsynonymous[Pro13Ser] 41 .. 41 C/T rs201256227 + CDS Synonymous[Pro13Pro] 57 .. 57 G/C rs202007582 + CDS Nonsynonymous[Val19Leu] 57 ^ 58 -/G rs35395786 + CDS 97 .. 97 G/A rs140679817 + CDS Nonsynonymous[Arg32Gln] 131 .. 131 C/T rs144891494 + CDS Synonymous[Pro43Pro] 301 .. 301 A/G rs187133761 + CDS Nonsynonymous[His100Arg] 307 .. 307 G/A rs138436598 + CDS Nonsynonymous[Ser102Asn] 317 .. 317 G/A rs55722725 + CDS Synonymous[Ser105Ser] 391 .. 391 C/T rs148988868 + CDS Nonsynonymous[Thr130Ile] 395 .. 395 A/G rs145790847 + CDS Synonymous[Val131Val] 404 .. 404 G/A rs200795779 + CDS Synonymous[Gly134Gly] 467 .. 467 G/A rs138497570 + CDS Synonymous[Gly155Gly] 476 .. 476 C/T rs78919227 + CDS Synonymous[Phe158Phe] 525 .. 525 A/G rs146138173 + CDS Nonsynonymous[Ile175Val] 563 .. 563 G/A rs56269509 + CDS Synonymous[Thr187Thr] 629 .. 629 G/A/T rs55664580 + CDS 632 .. 632 G/A rs184702498 + CDS Synonymous[Leu210Leu] 644 .. 644 T/C rs141395840 + CDS Synonymous[Asn214Asn] 682 .. 682 C/G rs150860380 + CDS Nonsynonymous[Ser227Cys] 731 .. 731 C/T rs139294759 + CDS Synonymous[Asn243Asn] 773 .. 773 C/T rs202149959 + CDS Synonymous[Phe257Phe] 794 .. 794 C/T rs201386540 + CDS Synonymous[Ser264Ser] 817 .. 817 A/G rs202143669 + CDS Nonsynonymous[Asn272Ser] 819 .. 819 G/A rs144455762 + CDS Nonsynonymous[Glu273Lys] 831 .. 831 T/C rs147407359 + CDS Synonymous[Leu277Leu] 870 .. 870 G/C rs201692399 + CDS Nonsynonymous[Glu290Gln] 977 .. 977 A/G rs112955689 + CDS Synonymous[Glu325Glu] 979 .. 979 G/A rs139618090 + CDS Nonsynonymous[Arg326Gln] 1006 .. 1006 A/G rs145309096 + CDS Nonsynonymous[Asn335Ser] 1022 .. 1022 T/C rs199729119 + CDS Synonymous[Pro340Pro] 1083 .. 1083 C/T rs34419285 + CDS Nonsynonymous[Leu361Phe] 1084 .. 1084 T/G rs145058405 + CDS Nonsynonymous[Leu361Arg] 1111 .. 1111 A/G rs149042459 + CDS Nonsynonymous[Tyr370Cys] 1122 .. 1122 G/A rs112642464 + CDS Nonsynonymous[Ala374Thr] 1127 .. 1127 G/A rs114347546 + CDS Synonymous[Glu375Glu] 1175 .. 1175 G/A rs151182341 + CDS Synonymous[Ser391Ser] 1196 .. 1196 C/T rs56412135 + CDS Synonymous[His398His] 1221 .. 1221 C/G rs140184613 + CDS Nonsynonymous[Arg407Gly] 1224 .. 1224 C/G rs200612683 + CDS Nonsynonymous[Leu408Val] 1302 .. 1302 C/T rs145303395 + CDS Nonsynonymous[Arg434Trp] 1303 .. 1303 G/A rs74839397 + CDS Nonsynonymous[Arg434Gln] 1335 .. 1335 A/C rs35643773 + CDS Nonsynonymous[Ser445Arg] 1338 .. 1338 C/G rs199515743 + CDS Nonsynonymous[Leu446Val] 1348 .. 1348 G/A rs141334351 + CDS Nonsynonymous[Ser449Asn] 1377 .. 1377 G/T rs192554076 + 3'UTR 1550 .. 1550 C/T rs12538034 + 3'UTR 1622 .. 1622 G/A rs186946911 + 3'UTR 1627 .. 1627 T/C rs117606486 + 3'UTR 1682 .. 1682 G/A rs79425377 + 3'UTR  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  No data available Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;