H-InvDB x AHG DB
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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000428320 Accession number: AK309454 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Similar to Mitogen-activated protein kinase kinase kinase 19; EC=2.7.11.1; Regulated in COPD, protein kinase; SPS1/STE20-related protein kinase YSK4;
 
 

Transcript original information
Accession number AK309454.1
CAGE tag ID NA
EST ID NA
Clone Number FELNG2001168
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (MAP3K19) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (MAP3K19);
Sequence data provider NA
Annotation project NA
Length of cDNA 1405[bp] (No. of exon:8)[A:464 T:355 G:290 C:296]
Devision HTC
Molecular type mRNA
Library origin Cell type NA
Tissue type lung
Develpmental stage fetal
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) CAGGAG;  TAGAAG; 
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0002473
Genomic location  G-integra Help Chromosome 2
Location 2q21.3
Position 135748911- 135805038
Strand -
Possible duplicated location(s) NA
Gene structure 8 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:80122
KEGG GENES KEGG GENES(80122)
GeneCard GeneCardMAP3K19*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000243832
Predicted CDS 676..1239;  187[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.691

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000428320
H-Inv cluster ID Locus viewHIX0002473
Accession number AK309454.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO;  Splicing isoformSplicing isoform
Coding potential  Help Protein coding; 
Definition Similar to Mitogen-activated protein kinase kinase kinase 19; EC=2.7.11.1; Regulated in COPD, protein kinase; SPS1/STE20-related protein kinase YSK4;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (Q56UN5)  [Identity/coverage = 99.01%/15.21%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 14702039154893341581562117344846ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol MAP3K19
HGNC aliases "Yeast Sps1/Ste20-related kinase 4 (S. cerevisiae)", "yeast Sps1/Ste20-related kinase 4 (S. cerevisiae)", "YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)"
HGNC name mitogen-activated protein kinase kinase kinase 19
DDBJ NA
UniProt MAP3K19
EC number EC 2.7.11.1non-specific serine/threonine protein kinase; 
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway 04150 :mTOR signaling pathway;  04210 :Apoptosis;  04310 :Wnt signaling pathway;  04320 :Dorso-ventral axis formation;  04340 :Hedgehog signaling pathway;  04350 :TGF-beta signaling pathway;  04360 :Axon guidance;  04370 :VEGF signaling pathway;  04510 :Focal adhesion;  04520 :Adherens junction;  04530 :Tight junction;  04540 :Gap junction;  04620 :Toll-like receptor signaling pathway;  04630 :Jak-STAT signaling pathway;  04660 :T cell receptor signaling pathway;  04662 :B cell receptor signaling pathway;  04664 :Fc epsilon RI signaling pathway;  04720 :Long-term potentiation;  04730 :Long-term depression;  04810 :Regulation of actin cytoskeleton;  04910 :Insulin signaling pathway;  04912 :GnRH signaling pathway;  04920 :Adipocytokine signaling pathway;  05010 :Alzheimer's disease;  05210 :Colorectal cancer; 
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000243832
No. of interaction NA
Interaction partner(s) NA
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:80122
KEGG GENES KEGG GENES(80122)
GeneCard GeneCardMAP3K19*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA


Subcellular localization information  Last modified:27-May-2015
WoLF PSORT nuclear;  cytosol;  extracellular; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
90 .. 90 G/A rs149383558 - 5'UTR
260 .. 260 C/T rs139806891 - 5'UTR
287 .. 287 G/A rs116660108 - 5'UTR
320 .. 320 G/A rs113908677 - 5'UTR
388 .. 388 G/A rs77480817 - 5'UTR
483 .. 483 G/A rs57133179 - 5'UTR
510 .. 510 A/G rs116818110 - 5'UTR
568 .. 568 A/G rs187186368 - 5'UTR
673 .. 673 T/C rs147672857 - 5'UTR
686 .. 686 C/A rs75648600 - CDS Nonsynonymous[Thr4Asn]
746 .. 746 G/A rs147635402 - CDS Nonsynonymous[Gly24Asp]
798 .. 798 T/C rs113061226 - CDS Synonymous[Gly41Gly]
847 .. 847 T/C rs151183639 - CDS Nonsynonymous[Phe58Leu]
891 .. 891 C/G rs148040063 - CDS Nonsynonymous[Asp72Glu]
926 .. 926 A/C rs201841965 - CDS Nonsynonymous[Gln84Pro]
963 .. 963 T/C rs145950712 - CDS Synonymous[Asn96Asn]
967 .. 967 A/T rs6715812 - CDS Nonsynonymous[Ile98Leu]
974 .. 974 C/T rs151112282 - CDS Nonsynonymous[Thr100Met]
1006 .. 1006 C/T rs141899370 - CDS Nonsynonymous[Arg111Trp]
1007 .. 1007 G/A rs147043490 - CDS Nonsynonymous[Arg111Gln]
1016 .. 1016 T/A rs190387950 - CDS Nonsynonymous[Val114Asp]
1019 .. 1019 T/A rs138992614 - CDS AA-STOP[Leu115*]
1029 .. 1029 G/A rs113569095 - CDS Synonymous[Glu118Glu]
1095 .. 1095 G/A rs6754977 - CDS Synonymous[Leu140Leu]
1119 .. 1119 A/G rs146453631 - CDS Synonymous[Arg148Arg]
1132 .. 1132 C/T rs150706097 - CDS Nonsynonymous[His153Tyr]
1301 .. 1301 A/T rs181555739 - 3'UTR
1363 .. 1363 T/C rs148699140 - 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
Type Start End Strand
Tigger2a 1295 1405 -
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer