H-InvDB x AHG DB
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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000428415 Accession number: AK309549 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Similar to Abelson tyrosine-protein kinase 2; EC=2.7.10.2; Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; Tyrosine-protein kinase ARG;
 
 

Transcript original information
Accession number AK309549.1
CAGE tag ID NA
EST ID NA
Clone Number HSYRA2000848
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (ABL2) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (ABL2);
Sequence data provider NA
Annotation project NA
Length of cDNA 1876[bp] (No. of exon:8)[A:495 T:489 G:481 C:411]
Devision HTC
Molecular type mRNA
Library origin Cell type synoviocytes from rheumatoid arthritis (HS-RA)
Tissue type NA
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) CAGAAG; 
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0001374
Genomic location  G-integra Help Chromosome 1
Location 1q25.2
Position 179085987- 179112211
Strand -
Possible duplicated location(s) NA
Gene structure 8 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:27
KEGG GENES KEGG GENES(27)
GeneCard GeneCardABL2*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000195667
Predicted CDS 33..1658;  541[aa];  Orientation:+3; 
Codon Adaptation Index (CAI). 0.734

Motif information
ORF

length(541),orf(33:1658)
MVLGTVLLPPNSYGRDQDTSLCCLCTEASESALPDLTDHFASCVEDGFEG
DKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVAL
YDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPV
NSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEG
RVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPK
CNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVA
VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMP
YGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNC
LVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIK
SDVWGKVERDFFSVSFYFFFYKCLDSLELLLRCSVSSTFTCHSSSVIQQA
FVKYLLSARTVLRTLHKQKYRPGVVAHVCNYSTLGRDGWIT*
a.a.
length
InterPro Name
length(61), motif(92:152) 61 IPR001452 SH3 domain [Domain]
length(86), motif(93:178) 86 IPR001452 SH3 domain [Domain]
length(57), motif(95:151) 57 IPR001452 SH3 domain [Domain]
length(11), motif(95:105) 11 IPR001452 SH3 domain [Domain]
length(47), motif(98:144) 47 IPR001452 SH3 domain [Domain]
length(16), motif(109:124) 16 IPR001452 SH3 domain [Domain]
length(13), motif(138:150) 13 IPR001452 SH3 domain [Domain]
length(112), motif(150:261) 112 IPR000980 SH2 domain [Domain]
length(141), motif(153:293) 141 IPR000980 SH2 domain [Domain]
length(84), motif(156:239) 84 IPR000980 SH2 domain [Domain]
length(15), motif(158:172) 15 IPR000980 SH2 domain [Domain]
length(76), motif(158:233) 76 IPR000980 SH2 domain [Domain]
length(91), motif(158:248) 91 IPR000980 SH2 domain [Domain]
length(11), motif(177:187) 11 IPR000980 SH2 domain [Domain]
length(12), motif(189:200) 12 IPR000980 SH2 domain [Domain]
length(11), motif(201:211) 11 IPR000980 SH2 domain [Domain]
length(15), motif(222:236) 15 IPR000980 SH2 domain [Domain]
length(202), motif(254:455) 202 IPR011009 Protein kinase-like domain [Domain]
length(182), motif(273:454) 182 IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
length(269), motif(273:541) 269 IPR000719 Protein kinase domain [Domain]
length(24), motif(279:302) 24 IPR017441 Protein kinase, ATP binding site [Binding_site]
length(14), motif(346:359) 14 IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
length(19), motif(384:402) 19 IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
length(13), motif(390:402) 13 IPR008266 Tyrosine-protein kinase, active site [Active_site]
length(11), motif(432:442) 11 IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000428415
H-Inv cluster ID Locus viewHIX0001374
Accession number AK309549.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO;  Splicing isoformSplicing isoform
Coding potential  Help Protein coding; 
Definition Similar to Abelson tyrosine-protein kinase 2; EC=2.7.10.2; Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; Tyrosine-protein kinase ARG;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (P42684)  [Identity/coverage = 98.99%/33.5%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 219857137872601274829012775773147020391472917915489334157357351588609816678104167104141696424317306540173448461752533217974005181822991866964818691976188107621894567419369195196903322006823120841568214066922141734322297987ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol ABL2
HGNC aliases "v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)", "v-abl Abelson murine leukemia viral oncogene homolog 2", "c-abl oncogene 2, non-receptor tyrosine kinase"
HGNC name ABL proto-oncogene 2, non-receptor tyrosine kinase
DDBJ NA
UniProt ABL2
EC number EC 2.7.10.2non-specific protein-tyrosine kinase; 
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway 04020 :Calcium signaling pathway;  04360 :Axon guidance;  04370 :VEGF signaling pathway;  04510 :Focal adhesion;  04520 :Adherens junction;  04530 :Tight junction;  04540 :Gap junction;  04630 :Jak-STAT signaling pathway;  04660 :T cell receptor signaling pathway;  04662 :B cell receptor signaling pathway;  04664 :Fc epsilon RI signaling pathway;  04670 :Leukocyte transendothelial migration;  04730 :Long-term depression;  04810 :Regulation of actin cytoskeleton;  04912 :GnRH signaling pathway;  04920 :Adipocytokine signaling pathway;  05120 :Epithelial cell signaling in Helicobacter pylori infection;  05130 :Pathogenic Escherichia coli infection - EHEC;  05131 :Pathogenic Escherichia coli infection - EPEC; 
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000195667
No. of interaction NA
Interaction partner(s) NA
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:27
KEGG GENES KEGG GENES(27)
GeneCard GeneCardABL2*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function transferase activity, transferring phosphorus-containing groups (GO:0016772);  ATP binding (GO:0005524);  protein kinase activity (GO:0004672);  protein binding (GO:0005515); 
Biological process protein amino acid phosphorylation (GO:0006468); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT nuclear;  cytosol;  extracellular; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
95 152 1aboA 6e-15 91.4 58/58 b.34.2.1
185 454 1nw1A 1e-39 9.3 270/365 d.144.1.8
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL liver; 
Probe
information DNAProbeLocator
AceGene NA
Affymetrix
GeneChip
HG-Focus NA
HG-U133 NA
HG-U133A NA
HG-U133A_2 NA
HG-U133B NA
HG-U133_Plus_2 NA
HG-U95 NA
HG-U95A NA
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 NA
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 NA
Whole Human Genome Oligo Microarray:PGID247 NA
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Disease/pathology information  DiseaseInfo Viewer LEGENDA Last modified:27-May-2015
Disease relation Disease name:NA
Related information in OMIM OMIM ID:  164690;  Title: V-ABL ABELSON MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 2
Co-localized orphan diseases NA
Disease related mutation NA
Literature-Extracted GENe-Disease Associations (LEGENDA) LEGENDA Gene name Entrez Gene ID:(27)
Disease Entrez Gene ID:(27)
Substance Entrez Gene ID:(27)
Related H-InvDB links DiseaseInfo ViewerDiseaseInfo ViewerLEGENDALEGENDA

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
3 .. 3 A/G rs185101319 - 5'UTR
41 .. 41 T/C rs200931513 - CDS Synonymous[Leu3Leu]
44 .. 44 G/A rs200959542 - CDS Synonymous[Gly4Gly]
67 .. 67 G/C rs1318056 - CDS Nonsynonymous[Ser12Thr]
99 .. 99 T/A rs201683367 - CDS Nonsynonymous[Cys23Ser]
102 .. 102 C/A rs202125612 - CDS Nonsynonymous[Leu24Met]
195 .. 195 G/A rs140292380 - CDS Nonsynonymous[Gly55Ser]
220 .. 220 G/A rs55655202 - CDS Nonsynonymous[Arg63His]
226 .. 226 A/G rs140935116 - CDS Nonsynonymous[Tyr65Cys]
279 .. 279 A/G rs201376490 - CDS Nonsynonymous[Lys83Glu]
293 .. 293 C/T rs200064313 - CDS Synonymous[Leu87Leu]
294 .. 294 G/A rs187540054 - CDS Nonsynonymous[Gly88Arg]
323 .. 323 C/T rs200298102 - CDS Synonymous[Phe97Phe]
324 .. 324 G/A rs201168871 - CDS Nonsynonymous[Val98Ile]
367 .. 367 G/A rs147306941 - CDS Nonsynonymous[Ser112Asn]
433 .. 433 G/A rs148596386 - CDS Nonsynonymous[Arg134His]
451 .. 451 G/T rs61821670 - CDS Nonsynonymous[Gly140Val]
496 ^ 497 -/A rs35945588 - CDS
531 .. 531 G/A rs149352120 - CDS Nonsynonymous[Ala167Thr]
637 .. 637 T/C rs112007604 - CDS Nonsynonymous[Val202Ala]
638 .. 638 G/A rs28914528 + CDS Synonymous[Val202Val]
863 .. 863 C/T rs180770623 - CDS Synonymous[His277His]
875 .. 875 C/T rs201235188 - CDS Synonymous[Gly281Gly]
896 .. 896 C/T rs56032037 - CDS Synonymous[Tyr288Tyr]
903 .. 903 G/A rs200847097 - CDS Nonsynonymous[Val291Ile]
926 .. 926 A/G rs28914532 + CDS Synonymous[Thr298Thr]
942 .. 942 T/C rs28914533 + CDS Synonymous[Leu304Leu]
1000 .. 1000 A/G rs192943572 - CDS Nonsynonymous[Glu323Gly]
1019 .. 1019 G/A rs143159520 - CDS Synonymous[Leu329Leu]
1057 .. 1057 T/G rs147552979 - CDS Nonsynonymous[Phe342Cys]
1070 .. 1070 T/G rs150181582 - CDS Synonymous[Thr346Thr]
1073 .. 1073 A/G rs139334603 - CDS Synonymous[Glu347Glu]
1093 .. 1093 T/A rs141559171 - CDS AA-STOP[Leu354*]
1127 .. 1127 G/A rs199688019 - CDS Synonymous[Glu365Glu]
1157 .. 1157 C/T rs201521779 - CDS Synonymous[Ala375Ala]
1284 .. 1284 T/C rs140036159 - CDS Synonymous[Leu418Leu]
1304 .. 1304 T/C rs142746259 - CDS Synonymous[Tyr424Tyr]
1389 .. 1389 G/A rs144729350 - CDS Nonsynonymous[Val453Ile]
1418 .. 1418 T/C rs74388525 - CDS Synonymous[Phe462Phe]
1420 .. 1420 C/T rs76040121 - CDS Nonsynonymous[Ser463Phe]
1431 .. 1431 T/A rs78629915 - CDS Nonsynonymous[Tyr467Asn]
1436 .. 1436 T/A rs139017377 - CDS Nonsynonymous[Phe468Leu]
1442 ^ 1443 -/T rs56346584 - CDS
1477 .. 1477 G/A rs191517026 - CDS Nonsynonymous[Arg482Gln]
1536 .. 1536 G/A rs146191539 - CDS Nonsynonymous[Val502Ile]
1546 .. 1546 T/G rs186481839 - CDS Nonsynonymous[Leu505Arg]
1618 .. 1618 G/A rs144505173 - CDS Nonsynonymous[Cys529Tyr]
1642 .. 1642 A/G rs181244513 - CDS Nonsynonymous[Asp537Gly]
1647 .. 1647 T/G rs115703163 - CDS Nonsynonymous[Trp539Gly]
1659 .. 1659 G/A rs188314277 - 3'UTR
1743 .. 1743 C/T rs183613361 - 3'UTR
1833 .. 1833 G/A rs181902372 - 3'UTR
1836 .. 1836 C/A rs61821668 - 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
Type Start End Strand
L2 140 217 -
L2a 1514 1574 -
AluSz 1594 1876 +
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer