H-InvDB_9.0 released on May 27, 2015. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

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H-Invitational ID: HIT000429911 Accession number: AK311045 Created date: 26-Mar-2013 Last modified: 27-May-2015 Definition: Similar to Abelson tyrosine-protein kinase 2 isoform e.

		Select format Flat file XML file Nucleotide sequence fasta Protein sequence fasta

Transcript original information Accession number AK311045.1 CAGE tag ID NA EST ID NA Clone Number UTERU3007045 Experimental resources   NBRC ; HGPD ; Antibody (ABL2) ; Catalog (ABL2); Sequence data provider NA Annotation project NA Length of cDNA 2137[bp] (No. of exon:10)[A:566 T:450 G:620 C:501] Devision HTC Molecular type mRNA Library origin Cell type NA Tissue type uterus Develpmental stage NA

Sequence quality information CDS feature Complete CDS Kozak sequence NA PolyA NA Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) CAGAAG;  Transcript quality feature NA Notes NA

GCTCGGTGGTTTAAAGACGGCGGCGGCGGTGGCGGCGGCGGCGGCGGCGT TGGGGGCGCGGAGCCGCGACAGGAGGAGGGAAAAGCAGAATCTGTGAGTC GCCTGGAGGCAGCGCGGCGGCTGCCGTGAGGAGGCCGGGTGCGGAGCCGC CGGTGGCCCAGCCACTCAGGGCCAGGGCCTGGGCTGGGAGGGAGAGACCG GAGCAGCGCCAGGAGCCCGAGGCCGGAGCCGAGGAGGAATGTGACCAGGG GTCGGCGGGGGCGCGGGAGTACGCGAGAGCAGGGATGGGGCAGCAGGTGG GCCGCGTCGGGGAAGCTCCGGGGCTCCAGCAGCCTCAGCCCCGCGGGATC CGGGGCAGCAGTGCAGCCAGGCCCTCCGGCCGCAGGCGGGACCCGGCGGG GCGCACCACAGAGACCGGCTTCAATATCTTCACCCAGCATGAAGCTTTGC ATCGTCCCTATGGTTGTGATGTTGAACCCCAGGCACTAAATGAGGCTATC AGGTGGAGCTCCAAGGAGAACTTGCTCGGAGCCACTGAGAGTGACCCTAA TCTCTTCGTTGCACTTTATGATTTTGTAGCAAGTGGTGATAACACACTCA GCATCACTAAAGGTGAAAAGCTACGAGTCCTTGGTTACAACCAGAATGGT GAGTGGAGTGAAGTTCGCTCTAAGAATGGGCAGGGCTGGGTGCCAAGCAA CTACATCACCCCAGTGAACAGCCTGGAAAAACACTCCTGGTACCATGGAC CTGTGTCACGCAGTGCAGCTGAGTATCTGCTCAGCAGTCTAATCAATGGC AGCTTCCTGGTGCGAGAAAGTGAGAGTAGCCCTGGGCAGCTGTCCATCTC GCTCAGGTACGAGGGACGTGTGTATCACTACAGGATCAATACCACTGCAG ATGGCAAGGTGTATGTGACTGCTGAGAGCCGCTTCAGCACCTTGGCAGAG CTTGTACACCATCACTCCACAGTGGCTGATGGGCTGGTGACAACATTACA CTACCCAGCACCCAAGTGTAATAAGCCTACAGTCTATGGTGTGTCCCCCA TCCACGACAAATGGGAAATGGAGCGAACAGATATTACCATGAAGCACAAA CTTGGGGGCGGTCAGTATGGAGAGGTTTACGTTGGCGTCTGGAAGAAATA CAGCCTTACAGTTGCTGTGAAAACATTGAAGGAAGATACCATGGAGGTAG AAGAATTCCTGAAAGAAGCTGCAGTAATGAAGGAAATCAAGCATCCTAAT CTGGTACAACTTTTAGGTGTGTGTACTTTGGAGCCACCATTTTACATTGT GACTGAATACATGCCATACGGGAATTTGCTGGATTACCTCCGAGAATGCA ACCGAGAAGAGGTGACTGCAGTTGTGCTGCTCTACATGGCCACTCAGATT TCTTCTGCAATGGAGTACTTAGAGAAGAAGAATTTCATCCATAGAGATCT TGCAGCTCGTAACTGCCTAGTGGGAGAAAACCATGTGGTAAAAGTGGCTG ACTTTGGCTTAAGTAGATTGATGATTGGAGACACTTATACTGCTCATGCT GGAGCCAAATTTCCTATTAAGTGGACAGCACCAGAGAGTCTTGCCTACAA TACCTTCTCAATTAAATCTGACGTCTGGGCTTTTGGGGTATTGTTGTGGG AAATTGCTACCTATGGAATGTCACCATATCCAGGTATTGACCTGTCTCAG GTCTATGACCTACTAGAAAAAGGATATCGAATGGAACAGCCTGAGGGATG CCCCCCTAAGGTTTATGAACTTATGAGAGCATGCTGGAAGTGGAGCCCTG CCGATAGGCCCTCTTTTGCTGAAACACACCAAGCTTTTGAAACCATGTTC CATGACTCCAGCATTTCTGAAGTTCTCCTACATTGTGCCAATCAGACGTG CATAACATTGTGAACCAAAAGACACAGAGCAGGATGATGCTAGCAACGTA TTCATAGTAACTCCAAACTGGAAACAACCTAAACATCCATCAAGAGGAGA ACAGGTGGATTGTGGTATATTCACACGTTGGCATGCTACACAGCAATGAG AACCCCTGCCACATGCAGCAGCGTGGACGAATCTACACACATGATACTGG GCGAAAGAAGCCAGACAAAAGAGTACATACTTTATGA

Gene structure information

H-Inv cluster ID		HIX0001374
Genomic location	Chromosome	1
	Location	1q25.2
	Position	179079716- 179198819
	Strand	-
Possible duplicated location(s)		NA
Gene structure		10 exon(s)
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:27;
	KEGG GENES	KEGG GENES(27);
	GeneCard	ABL2;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000197054 Predicted CDS 285..1913;  542[aa];  Orientation:+3;  Codon Adaptation Index (CAI). 0.747

MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFT QHEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVAS GDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKH SWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYR INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTV YGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKE DTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLD YLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENH VVKVADFGLSRLMIGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAF GVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC WKWSPADRPSFAETHQAFETMFHDSSISEVLLHCANQTCITL*

Motif information

	a.a. length	InterPro	Name
	61	IPR001452	SH3 domain [Domain]
	86	IPR001452	SH3 domain [Domain]
	57	IPR001452	SH3 domain [Domain]
	11	IPR001452	SH3 domain [Domain]
	47	IPR001452	SH3 domain [Domain]
	16	IPR001452	SH3 domain [Domain]
	13	IPR001452	SH3 domain [Domain]
	120	IPR000980	SH2 domain [Domain]
	141	IPR000980	SH2 domain [Domain]
	84	IPR000980	SH2 domain [Domain]
	76	IPR000980	SH2 domain [Domain]
	91	IPR000980	SH2 domain [Domain]
	15	IPR000980	SH2 domain [Domain]
	11	IPR000980	SH2 domain [Domain]
	12	IPR000980	SH2 domain [Domain]
	11	IPR000980	SH2 domain [Domain]
	15	IPR000980	SH2 domain [Domain]
	272	IPR011009	Protein kinase-like domain [Domain]
	252	IPR020635	Tyrosine-protein kinase, catalytic domain [Domain]
	251	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
	252	IPR000719	Protein kinase domain [Domain]
	24	IPR017441	Protein kinase, ATP binding site [Binding_site]
	14	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
	19	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
	13	IPR008266	Tyrosine-protein kinase, active site [Active_site]
	11	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
	23	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
	23	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]

Gene function information

H-Inv ID		HIT000429911
H-Inv cluster ID		HIX0001374
Accession number		AK311045.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		NO;  Splicing isoform
Coding potential		Protein coding;
Definition		Similar to Abelson tyrosine-protein kinase 2 isoform e.
Similarity category		Category: Similar to known protein(Category II).
		Similar to known protein (NP_001129473)  [Identity/coverage = 92.1%/95.76%] to Homo sapiens protein.
Experimental evidence		Protein evidence
PubMed ID		NA
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	ABL2
	HGNC aliases	"v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)", "v-abl Abelson murine leukemia viral oncogene homolog 2", "c-abl oncogene 2, non-receptor tyrosine kinase"
	HGNC name	ABL proto-oncogene 2, non-receptor tyrosine kinase
	DDBJ	NA
	UniProt	NA
EC number		EC 2.7.10.2non-specific protein-tyrosine kinase;
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		04020 :Calcium signaling pathway;  04360 :Axon guidance;  04370 :VEGF signaling pathway;  04510 :Focal adhesion;  04520 :Adherens junction;  04530 :Tight junction;  04540 :Gap junction;  04630 :Jak-STAT signaling pathway;  04660 :T cell receptor signaling pathway;  04662 :B cell receptor signaling pathway;  04664 :Fc epsilon RI signaling pathway;  04670 :Leukocyte transendothelial migration;  04730 :Long-term depression;  04810 :Regulation of actin cytoskeleton;  04912 :GnRH signaling pathway;  04920 :Adipocytokine signaling pathway;  05120 :Epithelial cell signaling in Helicobacter pylori infection;  05130 :Pathogenic Escherichia coli infection - EHEC;  05131 :Pathogenic Escherichia coli infection - EPEC;
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000197054
	No. of interaction	1
	Interaction partner(s)	HIP000023855;
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	NA
	IntAct	NA
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:27;
	KEGG GENES	KEGG GENES(27);
	GeneCard	ABL2;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Auto-annotated
Notes		NA
Related H-InvDB links		Gene family;  Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Molecular function	transferase activity, transferring phosphorus-containing groups (GO:0016772);  ATP binding (GO:0005524);  protein kinase activity (GO:0004672);  protein-tyrosine kinase activity (GO:0004713);  protein binding (GO:0005515);
Biological process	protein amino acid phosphorylation (GO:0006468);

Subcellular localization information

Last modified:27-May-2015

WoLF PSORT	nuclear;  cytosol;
Target P	Not predicted
SOSUI	soluble protein
TMHMM	soluble protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified:27-May-2015

Start End PDB_ID E-value Identity Coverage SCOP_ID 89 146 1aboA 6e-15 91.4 58/58 b.34.2.1 179 528 1nw1A 4e-54 8.9 349/365 d.144.1.8

Related H-InvDB links GTOP

Gene expression information

Last modified:27-May-2015

Tissue-specific expression			liver;
Probe information	AceGene		NA
	Affymetrix GeneChip	HG-Focus	NA
		HG-U133	NA
		HG-U133A	NA
		HG-U133A_2	NA
		HG-U133B	NA
		HG-U133_Plus_2	NA
		HG-U95	NA
		HG-U95A	NA
		HG-U95B	NA
		HG-U95C	NA
		HG-U95D	NA
		HG-U95E	NA
		HG-U95Av2	NA
		HuEx-1_0	NA
		HuGeneFL	NA
	Agilent	Human 1A Oligo Microarray:PGID215	NA
		Whole Human Genome Oligo Microarray:PGID247	NA
Related H-InvDB links			H-ANGEL;  DNAProbeLocator;

Disease/pathology information

Last modified:27-May-2015

Disease relation		Disease name:NA
Related information in OMIM		OMIM ID:  164690;  Title: V-ABL ABELSON MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 2
Co-localized orphan diseases		NA
Disease related mutation		NA
Literature-Extracted GENe-Disease Associations (LEGENDA)	Gene name	Entrez Gene ID:(27)
	Disease	Entrez Gene ID:(27)
	Substance	Entrez Gene ID:(27)
Related H-InvDB links		DiseaseInfo Viewer;  LEGENDA;

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 30 .. 30 T/-/C rs35484727 - 5'UTR 30 ^ 31 -/GGCGGC rs3046363 - 5'UTR 32 .. 32 G/-/TGG/CGGCGGTGG rs34507784 - 5'UTR 46 ^ 47 -/CGGCGG rs72422475 - 5'UTR 47 ^ 48 -/GGCGGC rs72207668 - 5'UTR 48 ^ 49 -/GCGGCG rs72055021 - 5'UTR 164 .. 164 A/G rs2306941 - 5'UTR 378 .. 378 G/A rs61821692 - CDS Nonsynonymous[Gly32Ser] 454 .. 454 G/A rs55655202 - CDS Nonsynonymous[Arg57His] 460 .. 460 A/G rs140935116 - CDS Nonsynonymous[Tyr59Cys] 513 .. 513 A/G rs201376490 - CDS Nonsynonymous[Lys77Glu] 527 .. 527 C/T rs200064313 - CDS Synonymous[Leu81Leu] 528 .. 528 G/A rs187540054 - CDS Nonsynonymous[Gly82Arg] 557 .. 557 C/T rs200298102 - CDS Synonymous[Phe91Phe] 558 .. 558 G/A rs201168871 - CDS Nonsynonymous[Val92Ile] 601 .. 601 G/A rs147306941 - CDS Nonsynonymous[Ser106Asn] 667 .. 667 G/A rs148596386 - CDS Nonsynonymous[Arg128His] 685 .. 685 G/T rs61821670 - CDS Nonsynonymous[Gly134Val] 730 ^ 731 -/A rs35945588 - CDS 765 .. 765 G/A rs149352120 - CDS Nonsynonymous[Ala161Thr] 871 .. 871 T/C rs112007604 - CDS Nonsynonymous[Val196Ala] 872 .. 872 G/A rs28914528 + CDS Synonymous[Val196Val] 1097 .. 1097 C/T rs180770623 - CDS Synonymous[His271His] 1109 .. 1109 C/T rs201235188 - CDS Synonymous[Gly275Gly] 1130 .. 1130 C/T rs56032037 - CDS Synonymous[Tyr282Tyr] 1137 .. 1137 G/A rs200847097 - CDS Nonsynonymous[Val285Ile] 1160 .. 1160 A/G rs28914532 + CDS Synonymous[Thr292Thr] 1176 .. 1176 T/C rs28914533 + CDS Synonymous[Leu298Leu] 1234 .. 1234 A/G rs192943572 - CDS Nonsynonymous[Glu317Gly] 1253 .. 1253 G/A rs143159520 - CDS Synonymous[Leu323Leu] 1291 .. 1291 T/G rs147552979 - CDS Nonsynonymous[Phe336Cys] 1304 .. 1304 T/G rs150181582 - CDS Synonymous[Thr340Thr] 1307 .. 1307 A/G rs139334603 - CDS Synonymous[Glu341Glu] 1327 .. 1327 T/A rs141559171 - CDS AA-STOP[Leu348*] 1361 .. 1361 G/A rs199688019 - CDS Synonymous[Glu359Glu] 1391 .. 1391 C/T rs201521779 - CDS Synonymous[Ala369Ala] 1518 .. 1518 T/C rs140036159 - CDS Synonymous[Leu412Leu] 1538 .. 1538 T/C rs142746259 - CDS Synonymous[Tyr418Tyr] 1623 .. 1623 G/A rs144729350 - CDS Nonsynonymous[Val447Ile] 1685 .. 1685 T/C rs138565389 - CDS Synonymous[Gly467Gly] 1715 .. 1715 A/C rs2274230 + CDS Synonymous[Leu477Leu] 1852 .. 1852 A/G rs146942033 - CDS Nonsynonymous[His523Arg] 1898 .. 1898 G/A rs117218074 - CDS Synonymous[Thr538Thr] 1899 .. 1899 T/C rs147444465 - CDS Nonsynonymous[Cys539Arg] 1907 .. 1907 A/G rs201386260 - CDS Synonymous[Thr541Thr] 1974 .. 1974 A/G rs74413397 - 3'UTR 2052 .. 2052 A/G rs188393910 - 3'UTR 2072 .. 2072 C/T rs28913884 + 3'UTR 2073 .. 2073 G/A rs182761002 - 3'UTR  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  Type Start End Strand MamRTE1 1322 1437 + L1ME3A 1844 2137 + Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;