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H-Invitational ID: HIT000433317 Accession number: AK314451 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Potassium voltage-gated channel subfamily S member 3; Delayed-rectifier K(+) channel alpha subunit 3; Voltage-gated potassium channel subunit Kv9.3;
 
 

Transcript original information
Accession number AK314451.1
CAGE tag ID NA
EST ID NA
Clone Number PUAEN2007383
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (KCNS3) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (KCNS3);
Sequence data provider NA
Annotation project NA
Length of cDNA 1877[bp] (No. of exon:3)[A:427 T:459 G:503 C:488]
Devision HTC
Molecular type mRNA
Library origin Cell type pulmonary artery endothelial cells (HPAEC)
Tissue type NA
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0001848
Genomic location  G-integra Help Chromosome 2
Location 2p24.2
Position 18059924- 18113751
Strand +
Possible duplicated location(s) NA
Gene structure 3 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:3790
KEGG GENES KEGG GENES(3790)
GeneCard GeneCardKCNS3*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000110737
Predicted CDS 402..1877;  491[aa];  Orientation:+3; 
Codon Adaptation Index (CAI). 0.801
Database links RefSeq NP_002243
UniProt Q9BQ31
CCDS CCDS1692

Motif information
ORF

length(491),orf(402:1877)
MVFGEFFHRPGQDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSE
EAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFC
QEIEYWGINELFIDSCCSNRYQERKEENHEKDWDQKSHDVSTDSSFEESS
LFEKELEKFDTLRFGQLRKKIWIRMENPAYCLSAKLIAISSLSVVLASIV
AMCVHSMSEFQNEDGEVDDPVLEGVEIACIAWFTGELAVRLAAAPCQKKF
WKNPLNIIDFVSIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRIFRI
LKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEKDDH
TSSLTSIPICWWWATISMTTVGYGDTHPVTLAGKLIASTCIICGILVVAL
PITIIFNKFSKYYQKQKDIDVDQCSEDAPEKCHELPYFNIRDIYAQRMHT
FITSLSSVGIVVSDPDSTDASSIEDNEDICNTTSLENCTAK*
a.a.
length
InterPro Name
length(480), motif(12:491) 480 IPR028325 Voltage-gated potassium channel [Family]
length(120), motif(13:132) 120 IPR011333 BTB/POZ fold [Domain]
length(115), motif(15:129) 115 IPR011333 BTB/POZ fold [Domain]
length(110), motif(15:124) 110 IPR000210 BTB/POZ-like [Domain]
length(100), motif(17:116) 100 IPR003131 Potassium channel tetramerisation-type BTB domain [Domain]
length(13), motif(20:32) 13 IPR003971 Potassium channel, voltage dependent, Kv9 [Family]
length(17), motif(35:51) 17 IPR003971 Potassium channel, voltage dependent, Kv9 [Family]
length(14), motif(58:71) 14 IPR003971 Potassium channel, voltage dependent, Kv9 [Family]
length(11), motif(66:76) 11 IPR003968 Potassium channel, voltage dependent, Kv [Family]
length(20), motif(66:85) 20 IPR003091 Potassium channel [Family]
length(16), motif(82:97) 16 IPR003971 Potassium channel, voltage dependent, Kv9 [Family]
length(13), motif(105:117) 13 IPR003971 Potassium channel, voltage dependent, Kv9 [Family]
length(134), motif(167:300) 134 IPR027359 Voltage-dependent channel, four helix bundle domain [Domain]
length(29), motif(178:206) 29 IPR003091 Potassium channel [Family]
length(13), motif(191:203) 13 IPR003971 Potassium channel, voltage dependent, Kv9 [Family]
length(24), motif(224:247) 24 IPR003091 Potassium channel [Family]
length(181), motif(225:405) 181 IPR005821 Ion transport domain [Domain]
length(21), motif(250:270) 21 IPR003091 Potassium channel [Family]
length(27), motif(294:320) 27 IPR003091 Potassium channel [Family]
length(9), motif(299:307) 9 IPR003968 Potassium channel, voltage dependent, Kv [Family]
length(15), motif(323:337) 15 IPR003968 Potassium channel, voltage dependent, Kv [Family]
length(24), motif(323:346) 24 IPR003091 Potassium channel [Family]
length(23), motif(354:376) 23 IPR003091 Potassium channel [Family]
length(27), motif(383:409) 27 IPR003091 Potassium channel [Family]
length(19), motif(393:411) 19 IPR003971 Potassium channel, voltage dependent, Kv9 [Family]
length(12), motif(394:405) 12 IPR003968 Potassium channel, voltage dependent, Kv [Family]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000433317
H-Inv cluster ID Locus viewHIX0001848
Accession number AK314451.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help Representative H-Inv IDRepresentative transcript;  Splicing isoformSplicing isoform
Coding potential  Help Protein coding; 
Definition Potassium voltage-gated channel subfamily S member 3; Delayed-rectifier K(+) channel alpha subunit 3; Voltage-gated potassium channel subunit Kv9.3;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (Q9BQ31)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 10484328147020391548933415815621ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol KCNS3
HGNC aliases "potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3"
HGNC name potassium voltage-gated channel, modifier subfamily S, member 3
DDBJ NA
UniProt KCNS3
EC number NA
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000110737
No. of interaction 2
Interaction partner(s) HIP000030159HIP000034631
BIND NA
DIP NA
MINT NA
HPRD 08983; 
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:3790
KEGG GENES KEGG GENES(3790)
GeneCard GeneCardKCNS3*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Human curated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
FR ID FR145694
Accession
Description
Location
PMID

Gene ontology information
Molecular function protein binding (GO:0005515);  voltage-gated potassium channel activity (GO:0005249);  ion channel activity (GO:0005216); 
Biological process ion transport (GO:0006811);  protein homooligomerization (GO:0051260);  potassium ion transport (GO:0006813); 
Cellular component membrane (GO:0016020);  voltage-gated potassium channel complex (GO:0008076); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT plasma membrane; 
Target P Other
SOSUI membrane protein
TMHMM membrane protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
15 108 1a68A 2e-11 31.8 85/87 d.42.1.2
244 322 2e9xC1 2e-16 10.1 79/105 a.278.1.3
Related H-InvDB links GTOP GTOP

Evolutionary information  Evola Help Last modified:27-May-2015
Relationship Species Accession number MGI Links
Orthology Mus sp. (Mouse) AK046054 MGI:2411440 G-integraG-integra
Orthology Bos sp. (Cow) AY940664 G-integraG-integra
Orthology Equus sp. (Horse) ENSECAT00000020941 G-integraG-integra
Orthology Macaca sp. (Macaque) ENSMMUT00000024176 G-integraG-integra
Orthology Oryzias sp. (Medaka) ENSORLT00000015656 G-integraG-integra
Orthology Pongo sp. (Orangutan) ENSPPYT00000014669 G-integraG-integra
Orthology Pan sp. (Chimpanzee) ENSPTRT00000021763 G-integraG-integra
Orthology Tetraodon sp. (Tetraodon) GSTENT00005668001 G-integraG-integra
Orthology Danio sp. (Zebrafish) NM_001128724 G-integraG-integra
Orthology Takifugu sp. (Fugu) SINFRUT00000166840 G-integraG-integra
Orthology Monodelphis sp. (Opossum) XM_001362140 G-integraG-integra
Orthology Gallus sp. (Chicken) XM_426211 G-integraG-integra
Orthology Canis sp. (Dog) XM_540095 G-integraG-integra
Orthology Rattus sp. (Rat) Y17607 G-integraG-integra
Phylogenetic tree [View by ATV]
Neighbor-joining (phb) 
Related H-InvDB links EvolaEvoladN/dS (under constraction); 

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
11 .. 11 A/T rs150298215 + 5'UTR
234 .. 234 A/G rs3788962 - 5'UTR
426 .. 426 C/T rs140025505 + CDS Nonsynonymous[Arg9Cys]
427 .. 427 G/A rs34458219 - CDS Nonsynonymous[Arg9His]
436 .. 436 A/C rs199562499 + CDS Nonsynonymous[Gln12Pro]
440 .. 440 C/T rs35186900 - CDS Synonymous[Asp13Asp]
464 .. 464 G/T rs35579067 - CDS Synonymous[Val21Val]
481 .. 481 C/A rs17851366 + CDS Nonsynonymous[Ser27Tyr]
490 .. 490 A/G rs138171852 + CDS Nonsynonymous[Gln30Arg]
544 .. 544 A/G rs150081174 + CDS Nonsynonymous[His48Arg]
545 .. 545 T/C rs149280575 + CDS Synonymous[His48His]
567 .. 567 C/T rs183137090 + CDS Synonymous[Leu56Leu]
581 .. 581 C/T rs188714292 + CDS Synonymous[Tyr60Tyr]
584 .. 584 T/C rs7569719 + CDS Synonymous[Ser61Ser]
599 .. 599 A/G rs4240213 + CDS Synonymous[Glu66Glu]
608 .. 608 T/C rs35875249 - CDS Synonymous[Phe69Phe]
656 .. 656 G/A rs145158300 + CDS Synonymous[Thr85Thr]
710 .. 710 C/T rs141345709 + CDS Synonymous[Ile103Ile]
760 .. 760 G/A rs147647932 + CDS Nonsynonymous[Arg120His]
763 .. 763 A/G rs147163003 + CDS Nonsynonymous[Tyr121Cys]
771 .. 771 C/T rs76178253 + CDS Nonsynonymous[Arg124Cys]
797 .. 797 C/T rs199665754 + CDS Synonymous[Asp132Asp]
832 .. 832 C/G rs201851493 + CDS Nonsynonymous[Ser144Cys]
851 .. 851 T/C rs113161575 + CDS Synonymous[Ser150Ser]
889 .. 889 G/A rs35020605 - CDS Nonsynonymous[Arg163Gln]
950 .. 950 C/T rs201603883 + CDS Synonymous[Ser183Ser]
963 .. 963 G/A rs142972265 + CDS Nonsynonymous[Ala188Thr]
966 .. 966 A/G rs116042532 + CDS Nonsynonymous[Ile189Val]
980 .. 980 C/T rs77630608 + CDS Synonymous[Ser193Ser]
981 .. 981 G/A rs200881412 + CDS Nonsynonymous[Val194Met]
998 .. 998 C/T rs113969475 + CDS Synonymous[Ile199Ile]
1011 .. 1011 G/A rs144701569 + CDS Nonsynonymous[Val204Ile]
1025 .. 1025 G/A rs140824188 + CDS Synonymous[Ser208Ser]
1061 .. 1061 G/A rs145593758 + CDS Synonymous[Pro220Pro]
1074 .. 1074 G/T rs17856097 + CDS Nonsynonymous[Val225Leu]
1084 .. 1084 C/T rs145204663 + CDS Nonsynonymous[Ala228Val]
1115 .. 1115 C/T rs114910715 + CDS Synonymous[Ala238Ala]
1116 .. 1116 G/A rs35353595 - CDS Nonsynonymous[Val239Ile]
1182 .. 1182 G/A rs142073653 + CDS Nonsynonymous[Val261Ile]
1209 .. 1209 T/C rs191735514 + CDS Synonymous[Leu270Leu]
1230 .. 1230 G/A rs201654025 + CDS Nonsynonymous[Glu277Lys]
1408 .. 1408 C/T rs138310384 + CDS Nonsynonymous[Ser336Phe]
1429 .. 1429 A/G rs140699625 + CDS Nonsynonymous[Tyr343Cys]
1434 .. 1434 G/A rs143152428 + CDS Nonsynonymous[Val345Met]
1498 .. 1498 T/C rs148665556 + CDS Nonsynonymous[Ile366Thr]
1529 .. 1529 C/T rs151225864 + CDS Synonymous[Thr376Thr]
1546 .. 1546 C/T rs34658212 - CDS Nonsynonymous[Ala382Val]
1549 .. 1549 G/A rs144718402 + CDS Nonsynonymous[Gly383Glu]
1559 .. 1559 C/T rs202189909 + CDS Synonymous[Ile386Ile]
1565 .. 1565 C/T rs148982914 + CDS Synonymous[Ser388Ser]
1634 .. 1634 G/A rs3747516 - CDS Synonymous[Lys411Lys]
1636 .. 1636 A/C rs146902579 + CDS Nonsynonymous[Tyr412Ser]
1732 .. 1732 A/G rs199829330 + CDS Nonsynonymous[Tyr444Cys]
1740 .. 1740 C/T rs142950694 + CDS Nonsynonymous[Arg447Trp]
1741 .. 1741 G/A rs78213799 + CDS Nonsynonymous[Arg447Gln]
1745 .. 1745 G/A rs144169570 + CDS Nonsynonymous[Met448Ile]
1748 .. 1748 C/T rs146515429 + CDS Synonymous[His449His]
1749 .. 1749 A/G rs4832524 + CDS Nonsynonymous[Thr450Ala]
1791 .. 1791 G/A rs150320186 + CDS Nonsynonymous[Asp464Asn]
1836 .. 1836 A/G rs142534840 + CDS Nonsynonymous[Ile479Val]
1845 .. 1845 A/G rs139306553 + CDS Nonsynonymous[Thr482Ala]
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer