H-InvDB x AHG DB
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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000436134 Accession number: BC167156 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Similar to Cyclin-dependent kinase 14.
 
 

Transcript original information
Accession number BC167156.1
CAGE tag ID NA
EST ID NA
Clone Number MGC:176691 IMAGE:8862570
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (CLDN12) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (CLDN12);
Sequence data provider NA
Annotation project NA
Length of cDNA 4974[bp] (No. of exon:14)[A:1488 T:1493 G:1014 C:979]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type Clones donated by Kazusa DNA Research Inst.
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA Site: 4958(+) Signal: 4934-4938(+)
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0006831
Genomic location  G-integra Help Chromosome 7
Location 7q21.13
Position 90338712- 90839905
Strand +
Possible duplicated location(s) NA
Gene structure 14 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:5218
KEGG GENES KEGG GENES(5218)
GeneCard GeneCardCLDN12*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000062429
Predicted CDS 145..1500;  451[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.74
Database links RefSeq NP_036527
UniProt NA
CCDS CCDS5619

Motif information
ORF

length(451),orf(145:1500)
MHGYFGCNAAAEPGYSAFVGTPQICVTKMSTRNCQGMDSVIKPLDTIPED
KKVRVQRTQSTFDPFEKPANQVKRVHSENNACINFKTSSTGKESPKVRRH
SSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRL
QEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLC
QYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTG
ELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGV
GCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKP
ERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEY
FSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAFGKNNSYGKSLSNSK
H*
a.a.
length
InterPro Name
length(294), motif(113:406) 294 IPR011009 Protein kinase-like domain [Domain]
length(285), motif(117:401) 285 IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain [Domain]
length(285), motif(117:401) 285 IPR000719 Protein kinase domain [Domain]
length(24), motif(123:146) 24 IPR017441 Protein kinase, ATP binding site [Binding_site]
length(13), motif(234:246) 13 IPR008271 Serine/threonine-protein kinase, active site [Active_site]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000436134
H-Inv cluster ID Locus viewHIX0006831
Accession number BC167156.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO; 
Coding potential  Help Protein coding; 
Definition Similar to Cyclin-dependent kinase 14.
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (NP_036527)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens protein.
Experimental evidence Protein evidence
PubMed ID NA
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol CLDN12
HGNC aliases NA
HGNC name claudin 12
DDBJ PFTK1
UniProt NA
EC number EC 2.7.11.22cyclin-dependent kinase; 
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway 04360 :Axon guidance;  04530 :Tight junction;  04540 :Gap junction;  04660 :T cell receptor signaling pathway; 
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000062429
No. of interaction 1
Interaction partner(s) HIP000022816
BIND NA
DIP NA
MINT NA
HPRD 00021;  00298;  00452;  00886;  01574;  01822;  03184;  04457;  05457;  06902;  10700; 
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:5218
KEGG GENES KEGG GENES(5218)
GeneCard GeneCardCLDN12*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function transferase activity, transferring phosphorus-containing groups (GO:0016772);  ATP binding (GO:0005524);  protein kinase activity (GO:0004672); 
Biological process protein amino acid phosphorylation (GO:0006468); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT nuclear;  cytosol; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
27 405 1nw1A 5e-42 7.8 345/365 d.144.1.8
Related H-InvDB links GTOP GTOP

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
110 .. 110 A/- rs67214827 + 5'UTR
134 .. 134 C/T rs200545348 + 5'UTR
136 .. 136 T/G rs201900265 + 5'UTR
139 .. 139 C/T rs11767691 + 5'UTR
151 .. 151 G/A rs200626528 + CDS Nonsynonymous[Gly3Ser]
164 .. 164 G/T rs16867927 + CDS Nonsynonymous[Cys7Phe]
181 .. 181 C/T rs200101624 + CDS Nonsynonymous[Pro13Ser]
183 .. 183 C/T rs201256227 + CDS Synonymous[Pro13Pro]
199 .. 199 G/C rs202007582 + CDS Nonsynonymous[Val19Leu]
199 ^ 200 -/G rs35395786 + CDS
239 .. 239 G/A rs140679817 + CDS Nonsynonymous[Arg32Gln]
273 .. 273 C/T rs144891494 + CDS Synonymous[Pro43Pro]
443 .. 443 A/G rs187133761 + CDS Nonsynonymous[His100Arg]
449 .. 449 G/A rs138436598 + CDS Nonsynonymous[Ser102Asn]
459 .. 459 G/A rs55722725 + CDS Synonymous[Ser105Ser]
533 .. 533 C/T rs148988868 + CDS Nonsynonymous[Thr130Ile]
537 .. 537 A/G rs145790847 + CDS Synonymous[Val131Val]
546 .. 546 G/A rs200795779 + CDS Synonymous[Gly134Gly]
609 .. 609 G/A rs138497570 + CDS Synonymous[Gly155Gly]
618 .. 618 C/T rs78919227 + CDS Synonymous[Phe158Phe]
667 .. 667 A/G rs146138173 + CDS Nonsynonymous[Ile175Val]
705 .. 705 G/A rs56269509 + CDS Synonymous[Thr187Thr]
771 .. 771 G/A/T rs55664580 + CDS
774 .. 774 G/A rs184702498 + CDS Synonymous[Leu210Leu]
786 .. 786 T/C rs141395840 + CDS Synonymous[Asn214Asn]
824 .. 824 C/G rs150860380 + CDS Nonsynonymous[Ser227Cys]
873 .. 873 C/T rs139294759 + CDS Synonymous[Asn243Asn]
915 .. 915 C/T rs202149959 + CDS Synonymous[Phe257Phe]
936 .. 936 C/T rs201386540 + CDS Synonymous[Ser264Ser]
959 .. 959 A/G rs202143669 + CDS Nonsynonymous[Asn272Ser]
961 .. 961 G/A rs144455762 + CDS Nonsynonymous[Glu273Lys]
973 .. 973 T/C rs147407359 + CDS Synonymous[Leu277Leu]
1012 .. 1012 G/C rs201692399 + CDS Nonsynonymous[Glu290Gln]
1119 .. 1119 A/G rs112955689 + CDS Synonymous[Glu325Glu]
1121 .. 1121 G/A rs139618090 + CDS Nonsynonymous[Arg326Gln]
1148 .. 1148 A/G rs145309096 + CDS Nonsynonymous[Asn335Ser]
1164 .. 1164 T/C rs199729119 + CDS Synonymous[Pro340Pro]
1225 .. 1225 C/T rs34419285 + CDS Nonsynonymous[Leu361Phe]
1226 .. 1226 T/G rs145058405 + CDS Nonsynonymous[Leu361Arg]
1253 .. 1253 A/G rs149042459 + CDS Nonsynonymous[Tyr370Cys]
1264 .. 1264 G/A rs112642464 + CDS Nonsynonymous[Ala374Thr]
1269 .. 1269 G/A rs114347546 + CDS Synonymous[Glu375Glu]
1317 .. 1317 G/A rs151182341 + CDS Synonymous[Ser391Ser]
1338 .. 1338 C/T rs56412135 + CDS Synonymous[His398His]
1363 .. 1363 C/G rs140184613 + CDS Nonsynonymous[Arg407Gly]
1366 .. 1366 C/G rs200612683 + CDS Nonsynonymous[Leu408Val]
1444 .. 1444 C/T rs145303395 + CDS Nonsynonymous[Arg434Trp]
1445 .. 1445 G/A rs74839397 + CDS Nonsynonymous[Arg434Gln]
1477 .. 1477 A/C rs35643773 + CDS Nonsynonymous[Ser445Arg]
1480 .. 1480 C/G rs199515743 + CDS Nonsynonymous[Leu446Val]
1490 .. 1490 G/A rs141334351 + CDS Nonsynonymous[Ser449Asn]
1519 .. 1519 G/T rs192554076 + 3'UTR
1692 .. 1692 C/T rs12538034 + 3'UTR
1764 .. 1764 G/A rs186946911 + 3'UTR
1769 .. 1769 T/C rs117606486 + 3'UTR
1824 .. 1824 G/A rs79425377 + 3'UTR
1864 .. 1864 A/- rs57373891 + 3'UTR
1893 .. 1893 C/A rs192257107 + 3'UTR
1965 .. 1965 C/A rs57094099 + 3'UTR
2018 .. 2018 T/C rs144273645 + 3'UTR
2034 .. 2034 A/C rs182871876 + 3'UTR
2044 .. 2044 C/T rs187761972 + 3'UTR
2142 .. 2142 G/A rs199596982 + 3'UTR
2164 .. 2164 G/A rs148336753 + 3'UTR
2213 .. 2213 T/C rs193211295 + 3'UTR
2265 .. 2265 A/G rs11771034 + 3'UTR
2398 .. 2398 C/G rs141408927 + 3'UTR
2575 .. 2575 C/T rs57055510 + 3'UTR
2655 .. 2655 C/T rs150812728 + 3'UTR
2790 .. 2790 G/T rs184400898 + 3'UTR
2883 .. 2883 C/A rs139897081 + 3'UTR
2886 .. 2886 A/T rs115756355 + 3'UTR
2904 .. 2904 C/A rs75278656 + 3'UTR
3059 .. 3059 T/G rs189356575 + 3'UTR
3155 .. 3155 C/G rs10274344 + 3'UTR
3227 .. 3227 A/C rs145279951 + 3'UTR
3351 .. 3351 G/T rs117668282 + 3'UTR
3411 .. 3411 G/C rs10274847 + 3'UTR
3425 .. 3425 A/C rs192242688 + 3'UTR
3501 .. 3501 G/C rs112230613 + 3'UTR
3503 .. 3503 G/A rs147228643 + 3'UTR
3582 .. 3582 A/G rs140485073 + 3'UTR
3595 .. 3595 G/C rs184302851 + 3'UTR
3614 .. 3614 T/C rs188648356 + 3'UTR
3660 .. 3660 G/A rs181757742 + 3'UTR
3666 .. 3666 G/A rs12534311 + 3'UTR
3757 .. 3757 G/C rs74331397 + 3'UTR
3760 ^ 3761 -/TC rs71733271 + 3'UTR
3761 ^ 3762 -/CT rs72454560 + 3'UTR
3772 ^ 3773 -/CT rs3841400 + 3'UTR
3773 .. 3773 G/C rs78047617 + 3'UTR
3775 .. 3775 C/G rs79441121 + 3'UTR
3797 .. 3797 C/G rs185913193 + 3'UTR
3917 .. 3917 G/A rs3814097 + 3'UTR
3920 .. 3920 C/G rs3814098 + 3'UTR
3933 .. 3933 A/G rs190426743 + 3'UTR
4176 .. 4176 G/A rs112279213 + 3'UTR
4200 .. 4200 A/G rs115148946 + 3'UTR
4335 .. 4335 T/C rs60682673 + 3'UTR
4357 .. 4357 G/A rs55696729 + 3'UTR
4461 .. 4461 T/C rs149731535 + 3'UTR
4497 .. 4497 C/T rs182252809 + 3'UTR
4552 .. 4552 T/- rs34622440 + 3'UTR
4650 .. 4650 C/A rs114813205 + 3'UTR
4702 ^ 4703 -/T rs11406790 + 3'UTR
4709 ^ 4710 -/T rs34658897 + 3'UTR
4717 ^ 4718 -/T/TT/TTT rs35145764 + 3'UTR
4718 .. 4718 G/T rs200323989 - 3'UTR
4718 ^ 4719 -/T/TTT rs67505260 + 3'UTR
4770 .. 4770 C/T rs17648 + 3'UTR
4789 .. 4789 A/G rs78870345 + 3'UTR
4802 .. 4802 T/G rs145508457 + 3'UTR
4858 .. 4858 G/T rs15322 - 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer