H-InvDB_9.0 released on May 27, 2015. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

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H-Invitational ID: HIT000487603 Accession number: AB451390 Created date: 26-Mar-2013 Last modified: 27-May-2015 Definition: Similar to Heterogeneous nuclear ribonucleoprotein K isoform a.

		Select format Flat file XML file Nucleotide sequence fasta Protein sequence fasta

Transcript original information Accession number AB451390.1 CAGE tag ID NA EST ID NA Clone Number FLJ08080AAAF Experimental resources   NBRC ; HGPD ; Sequence data provider NA Annotation project NA Length of cDNA 1392[bp] (No. of exon:14)[A:400 T:334 G:356 C:302] Devision HUM Molecular type mRNA Library origin Cell type NA Tissue type NA Develpmental stage NA

Sequence quality information CDS feature C-truncated Kozak sequence NA PolyA NA Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) NA Transcript quality feature Truncation;  Notes NA

ATGGAAACTGAACAGCCAGAAGAAACCTTCCCTAACACTGAAACCAATGG TGAATTTGGTAAACGCCCTGCAGAAGATATGGAAGAGGAACAAGCATTTA AAAGATCTAGAAACACTGATGAGATGGTTGAATTACGCATTCTGCTTCAG AGCAAGAATGCTGGGGCAGTGATTGGAAAAGGAGGCAAGAATATTAAGGC TCTCCGTACAGACTACAATGCCAGTGTTTCAGTCCCAGACAGCAGTGGCC CCGAGCGCATATTGAGTATCAGTGCTGATATTGAAACAATTGGAGAAATT CTGAAGAAAATCATCCCTACCTTGGAAGAGGGCCTGCAGTTGCCATCACC CACTGCAACCAGCCAGCTCCCGCTCGAATCTGATGCTGTGGAATGCTTAA ATTACCAACACTATAAAGGAAGTGACTTTGACTGCGAGTTGAGGCTGTTG ATTCATCAGAGTCTAGCAGGAGGAATTATTGGGGTCAAAGGTGCTAAAAT CAAAGAACTTCGAGAGAACACTCAAACCACCATCAAGCTTTTCCAGGAAT GCTGTCCTCATTCCACTGACAGAGTTGTTCTTATTGGAGGAAAACCCGAT AGGGTTGTAGAGTGCATAAAGATCATCCTTGATCTTATATCTGAGTCTCC CATCAAAGGACGTGCACAGCCTTATGATCCCAATTTTTACGATGAAACCT ATGATTATGGTGGTTTTACAATGATGTTTGATGACCGTCGCGGACGCCCA GTGGGATTTCCCATGCGGGGAAGAGGTGGTTTTGACAGAATGCCTCCTGG TCGGGGTGGGCGTCCCATGCCTCCATCTAGAAGAGATTATGATGATATGA GCCCTCGTCGAGGACCACCTCCCCCTCCTCCCGGACGAGGCGGCCGGGGT GGTAGCAGAGCTCGGAATCTTCCTCTTCCTCCACCACCACCACCTAGAGG GGGAGACCTCATGGCCTATGACAGAAGAGGGAGACCTGGAGACCGTTACG ACGGCATGGTTGGTTTCAGTGCTGATGAAACTTGGGACTCTGCAATAGAT ACATGGAGCCCATCAGAATGGCAGATGGCTTATGAACCACAGGGTGGCTC CGGATATGATTATTCCTATGCAGGGGGTCGTGGCTCATATGGTGATCTTG GTGGACCTATTATTACTACACAAGTAACTATTCCCAAAGATTTGGCTGGA TCTATTATTGGCAAAGGTGGTCAGCGGATTAAACAAATCCGTCATGAGTC GGGAGCTTCGATCAAAATTGATGAGCCTTTAGAAGGATCCGAAGATCGGA TCATTACCATTACAGGAACACAGGACCAGATACAGAATGCACAGTATTTG CTGCAGAACAGTGTGAAGCAGTATGCAGATGTTGAAGGATTC

Gene structure information

H-Inv cluster ID		HIX0008131
Genomic location	Chromosome	9
	Location	9q21.32
	Position	86584325- 86593167
	Strand	-
Possible duplicated location(s)		NA
Gene structure		14 exon(s)
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:3190;
	KEGG GENES	KEGG GENES(3190);
	GeneCard	NA *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000051001 Predicted CDS 1..1392;  464[aa];  Orientation:+1;  Codon Adaptation Index (CAI). 0.738 Database links RefSeq NP_002131;  NP_112553;  UniProt Q4R4M6;  Q5R5H8;  CCDS CCDS6668;

METEQPEETFPNTETNGEFGKRPAEDMEEEQAFKRSRNTDEMVELRILLQ SKNAGAVIGKGGKNIKALRTDYNASVSVPDSSGPERILSISADIETIGEI LKKIIPTLEEGLQLPSPTATSQLPLESDAVECLNYQHYKGSDFDCELRLL IHQSLAGGIIGVKGAKIKELRENTQTTIKLFQECCPHSTDRVVLIGGKPD RVVECIKIILDLISESPIKGRAQPYDPNFYDETYDYGGFTMMFDDRRGRP VGFPMRGRGGFDRMPPGRGGRPMPPSRRDYDDMSPRRGPPPPPPGRGGRG GSRARNLPLPPPPPPRGGDLMAYDRRGRPGDRYDGMVGFSADETWDSAID TWSPSEWQMAYEPQGGSGYDYSYAGGRGSYGDLGGPIITTQVTIPKDLAG SIIGKGGQRIKQIRHESGASIKIDEPLEGSEDRIITITGTQDQIQNAQYL LQNSVKQYADVEGF

Motif information

	a.a. length	InterPro	Name
	43	IPR012987	ROK, N-terminal [Domain]
	73	IPR004088	K Homology domain, type 1 [Domain]
	69	IPR004087	K Homology domain [Domain]
	63	IPR004088	K Homology domain, type 1 [Domain]
	59	IPR004088	K Homology domain, type 1 [Domain]
	80	IPR004088	K Homology domain, type 1 [Domain]
	80	IPR004088	K Homology domain, type 1 [Domain]
	72	IPR004087	K Homology domain [Domain]
	66	IPR004088	K Homology domain, type 1 [Domain]
	63	IPR004088	K Homology domain, type 1 [Domain]
	79	IPR004088	K Homology domain, type 1 [Domain]
	74	IPR004088	K Homology domain, type 1 [Domain]
	71	IPR004087	K Homology domain [Domain]
	65	IPR004088	K Homology domain, type 1 [Domain]
	62	IPR004088	K Homology domain, type 1 [Domain]

Gene function information

H-Inv ID		HIT000487603
H-Inv cluster ID		HIX0008131
Accession number		AB451390.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		NO;
Coding potential		Protein coding;
Definition		Similar to Heterogeneous nuclear ribonucleoprotein K isoform a.
Similarity category		Category: Similar to known protein(Category II).
		Similar to known protein (NP_002131)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens protein.
Experimental evidence		Protein evidence
PubMed ID		NA
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	NA
	HGNC aliases	NA
	HGNC name	NA
	DDBJ	HNRNPK
	UniProt	NA
EC number		NA
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000051001
	No. of interaction	18
	Interaction partner(s)	HIP000022035;  HIP000022049;  HIP000022971;  HIP000022971;  HIP000023960;  HIP000025001;  HIP000030471;  HIP000039590;  HIP000039653;  HIP000040680;  HIP000057536;  HIP000058310;  HIP000064456;  HIP000076215;  HIP000076215;  HIP000079240;  HIP000091500;  HIP000095024;
	BIND	145824;  177285;  177286;  19219;  24463;  24472;  263126;  50116;  50117;  50266;  54906;  57935;  57936;  57937;  57938;
	DIP	102592E;  111677E;  111706E;  112072E;  144758E;  151748E;  151750E;  151752E;  175753E;  179997E;  185077E;  185374E;
	MINT	MINT-2855592;  MINT-2859739;  MINT-2859758;  MINT-2859777;  MINT-3296872;  MINT-5205854;  MINT-6803834;  MINT-6803853;  MINT-6803869;  MINT-6803896;  MINT-6803939;  MINT-6823857;  MINT-6823877;  MINT-7035260;  MINT-7035286;  MINT-7035298;  MINT-7035309;  MINT-7035323;  MINT-7035338;  MINT-7945693;  MINT-7947479;  MINT-8200625;  MINT-8200636;  MINT-8200651;  MINT-8201404;  MINT-8201427;  MINT-8201449;
	HPRD	00146;  00298;  00496;  00535;  00579;  00589;  00655;  00796;  01095;  01228;  01284;  01301;  01501;  01726;  01746;  01801;  01818;  01819;  02186;  02511;  02877;  03128;  03129;  03144;  03158;  03183;  03926;  04066;  04184;  04205;  04207;  04257;  04340;  04360;  04530;  05059;  05088;  05156;  05270;  05378;  05496;  06515;  06691;  07601;  09045;  09060;  09113;  09273;  10007;  11303;  11488;  11535;  12048;  12752;  13775;  14358;  15334;  15998;  16246;  17835;  18043;
	IntAct	NA
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:3190;
	KEGG GENES	KEGG GENES(3190);
	GeneCard	NA *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Auto-annotated
Notes		NA
Related H-InvDB links		Gene family;  Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Molecular function	nucleic acid binding (GO:0003676);  RNA binding (GO:0003723);

Subcellular localization information

Last modified:27-May-2015

WoLF PSORT	nuclear;  cytosol;
Target P	Other
SOSUI	soluble protein
TMHMM	soluble protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified:27-May-2015

Start End PDB_ID E-value Identity Coverage SCOP_ID 40 110 2axyA1 3e-10 29.6 71/71 d.51.1.1 144 251 2dp9A1 2e-17 11.0 100/120 b.122.1.5 384 457 1we8A 2e-04 17.1 74/104 d.51.1.1

Related H-InvDB links GTOP

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 6 .. 6 A/G rs202064506 - CDS Synonymous[Glu2Glu] 16 .. 16 C/T rs150076109 - CDS Nonsynonymous[Pro6Ser] 45 .. 45 C/T rs199952772 - CDS Synonymous[Thr15Thr] 72 .. 72 A/C rs114536498 - CDS Synonymous[Ala24Ala] 75 .. 75 A/G rs11548845 + CDS Synonymous[Glu25Glu] 243 .. 243 C/T rs201251896 - CDS Synonymous[Ser81Ser] 321 .. 321 C/T rs11548846 + CDS Synonymous[Thr107Thr] 386 .. 386 C/G rs140707980 - CDS Nonsynonymous[Ala129Gly] 435 .. 435 C/T rs116557087 - CDS Synonymous[Cys145Cys] 519 .. 519 C/T rs143811423 - CDS Synonymous[Asn173Asn] 528 .. 528 C/G rs201881795 - CDS Synonymous[Thr176Thr] 593 .. 593 A/G rs111725016 - CDS Nonsynonymous[Lys198Arg] 690 .. 690 C/T rs200783060 - CDS Synonymous[Tyr230Tyr] 984 .. 984 A/G rs140679593 - CDS Synonymous[Arg328Arg] 1062 .. 1062 A/T rs114279043 - CDS Synonymous[Pro354Pro] 1102 .. 1102 G/C rs182293768 - CDS Nonsynonymous[Gly368Arg] 1119 .. 1119 T/C rs143712714 - CDS Synonymous[Tyr373Tyr] 1140 .. 1140 T/C rs181141777 - CDS Synonymous[Tyr380Tyr] 1206 .. 1206 T/C rs115527397 - CDS Synonymous[Ile402Ile] 1236 .. 1236 A/G rs61755088 - CDS Synonymous[Gln412Gln] 1290 .. 1290 C/T rs115346013 - CDS Synonymous[Ser430Ser]  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  No data available Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;