H-InvDB x AHG DB
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H-Invitational ID: HIT000490150 Accession number: AK295526 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Similar to Alpha-aminoadipic semialdehyde dehydrogenase isoform 2.
 
 

Transcript original information
Accession number AK295526.1
CAGE tag ID NA
EST ID NA
Clone Number BRHIP2014109
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (ALDH7A1) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (ALDH7A1);
Sequence data provider NA
Annotation project NA
Length of cDNA 1355[bp] (No. of exon:12)[A:390 T:356 G:343 C:266]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type hippocampus
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) TAGGAG; 
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0216685
Genomic location  G-integra Help Chromosome 5
Location 5q23.2
Position 125880349- 125930893
Strand -
Possible duplicated location(s) NA
Gene structure 12 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:501
KEGG GENES KEGG GENES(501)
GeneCard GeneCardALDH7A1*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000249817
Predicted CDS 4..1047;  347[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.753

Motif information
ORF

length(347),orf(4:1047)
MWRLPRALCVHAAKTSKLSGPWSRPAAFMSTSLISVAVTKIIAKVLEDNK
LPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGR
SLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESI
HDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEG
GTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEE
EVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEI
GGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYSKDLPLAQGIKFQ*
a.a.
length
InterPro Name
length(302), motif(34:335) 302 IPR016161 Aldehyde/histidinol dehydrogenase [Domain]
length(293), motif(36:328) 293 IPR015590 Aldehyde dehydrogenase domain [Domain]
length(81), motif(37:117) 81 IPR016162 Aldehyde dehydrogenase N-terminal domain [Domain]
length(8), motif(103:110) 8 IPR029510 Aldehyde dehydrogenase, glutamic acid active site [Conserved_site]
length(179), motif(118:296) 179 IPR016163 Aldehyde dehydrogenase, C-terminal [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000490150
H-Inv cluster ID Locus viewHIX0216685
Accession number AK295526.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO;  Splicing isoformSplicing isoform
Coding potential  Help Protein coding; 
Definition Similar to Alpha-aminoadipic semialdehyde dehydrogenase isoform 2.
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (NP_001188306)  [Identity/coverage = 99.686%/62.23%] to Homo sapiens protein.
Experimental evidence Protein evidence
PubMed ID NA
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol ALDH7A1
HGNC aliases NA
HGNC name aldehyde dehydrogenase 7 family, member A1
DDBJ NA
UniProt NA
EC number EC 1.2.1.3aldehyde dehydrogenase (NAD+); 
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway 00010 :Glycolysis / Gluconeogenesis;  00053 :Ascorbate and aldarate metabolism;  00071 :Fatty acid metabolism;  00120 :Bile acid biosynthesis;  00280 :Valine, leucine and isoleucine degradation;  00310 :Lysine degradation;  00330 :Arginine and proline metabolism;  00340 :Histidine metabolism;  00380 :Tryptophan metabolism;  00410 :beta-Alanine metabolism;  00561 :Glycerolipid metabolism;  00620 :Pyruvate metabolism;  00631 :1,2-Dichloroethane degradation;  00640 :Propanoate metabolism;  00650 :Butanoate metabolism;  00903 :Limonene and pinene degradation; 
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000249817
No. of interaction NA
Interaction partner(s) NA
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:501
KEGG GENES KEGG GENES(501)
GeneCard GeneCardALDH7A1*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor (GO:0016620);  oxidoreductase activity (GO:0016491); 
Biological process metabolic process (GO:0008152); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT mitochondria; 
Target P mitochondria
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
33 334 1uzbA 2e-62 26.1 295/516 c.82.1.1
Related H-InvDB links GTOP GTOP

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
42 .. 42 A/G rs201566142 - CDS Synonymous[Ala13Ala]
46 .. 46 A/T rs1049211 + CDS Nonsynonymous[Thr15Ser]
63 .. 63 A/T rs1049214 + CDS Synonymous[Gly20Gly]
69 .. 69 G/C rs1049217 + CDS Nonsynonymous[Trp22Cys]
81 .. 81 C/T rs11542969 + CDS Synonymous[Ala26Ala]
157 .. 157 C/A rs140701322 - CDS Nonsynonymous[Pro52Thr]
261 .. 261 G/A rs201948406 - CDS Synonymous[Val86Val]
285 .. 285 G/A rs150623275 - CDS Synonymous[Val94Val]
329 .. 329 A/T rs121912711 + CDS Nonsynonymous[Asn109Ile]
341 .. 341 C/G rs141775154 - CDS Nonsynonymous[Ala113Gly]
357 .. 357 C/T rs202069068 - CDS Synonymous[Asp118Asp]
377 .. 377 C/T rs148052962 - CDS Nonsynonymous[Ser125Leu]
387 .. 387 C/T rs114516357 - CDS Synonymous[Phe128Phe]
389 .. 389 C/T rs3189320 + CDS Nonsynonymous[Ala129Val]
425 .. 425 C/T rs144625212 - CDS Nonsynonymous[Ala141Val]
427 .. 427 A/G rs111319259 - CDS Nonsynonymous[Arg142Gly]
443 .. 443 A/G rs199767457 - CDS Nonsynonymous[His147Arg]
444 .. 444 T/C rs200394848 - CDS Synonymous[His147His]
449 .. 449 G/A rs141701364 - CDS Nonsynonymous[Ser149Asn]
493 .. 493 C/G rs138675705 - CDS Nonsynonymous[Gln164Glu]
500 .. 500 G/T rs144671885 - CDS Nonsynonymous[Arg166Leu]
503 .. 503 T/C rs201752552 - CDS Nonsynonymous[Val167Ala]
560 .. 560 T/C rs7447092 - CDS Nonsynonymous[Val186Ala]
577 .. 577 G/A rs140947675 - CDS Nonsynonymous[Ala192Thr]
637 .. 637 C/T rs181287032 - CDS Nonsynonymous[Arg212Cys]
651 .. 651 T/G rs121912710 + CDS AA-STOP[Tyr216*]
661 .. 661 A/G rs56220725 + CDS Nonsynonymous[Thr220Ala]
661 .. 661 A/G rs2306618 - CDS Nonsynonymous[Thr220Ala]
664 .. 664 A/G rs201792544 - CDS Nonsynonymous[Ile221Val]
703 .. 703 A/G rs150305320 - CDS Nonsynonymous[Thr234Ala]
706 .. 706 G/C rs121912707 + CDS Nonsynonymous[Glu235Gln]
719 .. 719 C/T rs151107837 - CDS Nonsynonymous[Pro239Leu]
732 .. 732 C/G rs142975776 - CDS Synonymous[Val243Val]
742 .. 742 A/C rs12514417 - CDS Nonsynonymous[Lys247Gln]
776 .. 776 A/G rs200299784 - CDS Nonsynonymous[Glu258Gly]
777 .. 777 A/G rs200980969 - CDS Synonymous[Glu258Glu]
802 .. 802 A/T rs186558364 - CDS Nonsynonymous[Ile267Phe]
823 .. 823 A/G rs113609617 - CDS Nonsynonymous[Arg274Gly]
833 .. 833 G/A rs147940248 - CDS Nonsynonymous[Arg277His]
869 .. 869 T/C rs144701796 - CDS Nonsynonymous[Val289Ala]
913 .. 913 T/C rs202104680 - CDS Nonsynonymous[Phe304Leu]
947 .. 947 A/G rs80049945 - CDS Nonsynonymous[Glu315Gly]
974 .. 974 A/G rs200102503 - CDS Nonsynonymous[Tyr324Cys]
994 .. 994 A/G rs61757684 - CDS Nonsynonymous[Thr331Ala]
1115 .. 1115 G/A rs2775 + 3'UTR
1196 .. 1196 A/G rs187827993 - 3'UTR
1259 .. 1259 A/C rs143317618 - 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer