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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000490294 Accession number: AK295670 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Similar to Guanine nucleotide exchange factor DBS isoform a.
 
 

Transcript original information
Accession number AK295670.1
CAGE tag ID NA
EST ID NA
Clone Number BRHIP3009891
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ;
Sequence data provider NA
Annotation project NA
Length of cDNA 3594[bp] (No. of exon:30)[A:832 T:574 G:1162 C:1026]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type hippocampus
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) CAGAAG;  CAGGAG; 
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0011471
Genomic location  G-integra Help Chromosome 13
Location 13q34
Position 113623693- 113751388
Strand +
Possible duplicated location(s) NA
Gene structure 30 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:23263
KEGG GENES KEGG GENES(23263)
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000249948
Predicted CDS 2..3379;  1125[aa];  Orientation:+2; 
Codon Adaptation Index (CAI). 0.827

Motif information
ORF

length(1125),orf(2:3379)
MRFWLRTEEMALEEMVQRLNAVSKHTDEIMHQDIVPLCAADIQDQLKKRF
AYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIG
FILVIDRRRDKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIA
FKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQ
RTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDK
AKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLN
ETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDI
GNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIR
PKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLAS
QPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLM
EHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEALAKSPC
PSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAI
LRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDV
LFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMEDLQIYEKYCQN
KPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKE
MLKYSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKL
LMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGE
GYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQAPTP
EIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGN
SRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDG
...
a.a.
length
InterPro Name
length(173), motif(22:194) 173 IPR001251 CRAL-TRIO domain [Domain]
length(155), motif(41:195) 155 IPR001251 CRAL-TRIO domain [Domain]
length(147), motif(45:191) 147 IPR001251 CRAL-TRIO domain [Domain]
length(143), motif(52:194) 143 IPR001251 CRAL-TRIO domain [Domain]
length(103), motif(322:424) 103 IPR002017 Spectrin repeat [Repeat]
length(102), motif(324:425) 102 IPR018159 Spectrin/alpha-actinin [Repeat]
length(190), motif(594:783) 190 IPR000219 Dbl homology (DH) domain [Domain]
length(188), motif(596:783) 188 IPR000219 Dbl homology (DH) domain [Domain]
length(181), motif(601:781) 181 IPR000219 Dbl homology (DH) domain [Domain]
length(176), motif(605:780) 176 IPR000219 Dbl homology (DH) domain [Domain]
length(26), motif(730:755) 26 IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site [Conserved_site]
length(150), motif(786:935) 150 IPR011993 Pleckstrin homology-like domain [Domain]
length(117), motif(799:915) 117 IPR001849 Pleckstrin homology domain [Domain]
length(118), motif(800:917) 118 IPR001849 Pleckstrin homology domain [Domain]
length(58), motif(1028:1085) 58 IPR001452 SH3 domain [Domain]
length(56), motif(1028:1083) 56 IPR001452 SH3 domain [Domain]
length(53), motif(1031:1083) 53 IPR011511 Variant SH3 domain [Domain]
length(52), motif(1035:1086) 52 IPR001452 SH3 domain [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000490294
H-Inv cluster ID Locus viewHIX0011471
Accession number AK295670.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help Representative H-Inv IDRepresentative transcript;  Splicing isoformSplicing isoform
Coding potential  Help Protein coding; 
Definition Similar to Guanine nucleotide exchange factor DBS isoform a.
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (NP_001106203)  [Identity/coverage = 99.733%/100.0%] to Homo sapiens protein.
Experimental evidence Protein evidence
PubMed ID NA
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol NA
HGNC aliases NA
HGNC name NA
DDBJ NA
UniProt NA
EC number NA
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000249948
No. of interaction 3
Interaction partner(s) HIP000000536HIP000029955HIP000066489
BIND NA
DIP NA
MINT NA
HPRD 00309;  01323;  01537; 
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:23263
KEGG GENES KEGG GENES(23263)
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Human curated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function guanyl-nucleotide exchange factor activity (GO:0005085);  Rho guanyl-nucleotide exchange factor activity (GO:0005089);  protein binding (GO:0005515); 
Biological process regulation of Rho protein signal transduction (GO:0035023); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT nuclear;  cytosol; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Twilight zone
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
42 213 1oipA2 5e-29 14.1 170/185 c.13.1.1
204 323 1hciA3 1e-12 15.8 114/121 a.7.1.1
315 430 1hciA2 4e-19 19.3 114/115 a.7.1.1
417 533 1hciA1 5e-07 10.4 115/125 a.7.1.1
593 787 1kz7A1 7e-40 89.7 195/195 a.87.1.1
788 931 1kz7A2 7e-64 94.2 139/142 b.55.1.1
1030 1115 1uffA 2e-10 18.6 86/93 b.34.2.1
Related H-InvDB links GTOP GTOP

Evolutionary information  Evola Help Last modified:27-May-2015
Relationship Species Accession number MGI Links
Orthology Mus sp. (Mouse) BC058622 MGI:103263 G-integraG-integra
Orthology Bos sp. (Cow) BC148999 G-integraG-integra
Orthology Pongo sp. (Orangutan) CR857548 G-integraG-integra
Orthology Oryzias sp. (Medaka) ENSORLT00000007089 G-integraG-integra
Orthology Rattus sp. (Rat) ENSRNOT00000023352 G-integraG-integra
Orthology Tetraodon sp. (Tetraodon) GSTENT00025929001 G-integraG-integra
Orthology Takifugu sp. (Fugu) SINFRUT00000141704 G-integraG-integra
Orthology Takifugu sp. (Fugu) SINFRUT00000166141 G-integraG-integra
Orthology Macaca sp. (Macaque) XM_001103476 G-integraG-integra
Orthology Monodelphis sp. (Opossum) XM_001374260 G-integraG-integra
Orthology Equus sp. (Horse) XM_001497175 G-integraG-integra
Orthology Danio sp. (Zebrafish) XM_001922148 G-integraG-integra
Orthology Gallus sp. (Chicken) XM_416947 G-integraG-integra
Orthology Pan sp. (Chimpanzee) XM_509745 G-integraG-integra
Orthology Canis sp. (Dog) XM_542673 G-integraG-integra
Phylogenetic tree [View by ATV]
Neighbor-joining (phb) 
Related H-InvDB links EvolaEvoladN/dS (under constraction); 

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
20 .. 20 A/C rs148315657 + CDS Nonsynonymous[Thr7Pro]
83 .. 83 G/A rs146840178 + CDS Nonsynonymous[Glu28Lys]
101 .. 101 A/T rs181380349 + CDS Nonsynonymous[Ile34Phe]
103 .. 103 C/T rs139777066 + CDS Synonymous[Ile34Ile]
146 .. 146 C/T rs144497036 + CDS Nonsynonymous[Arg49Cys]
148 .. 148 C/T rs146679056 + CDS Synonymous[Arg49Arg]
163 .. 163 C/T rs149468042 + CDS Synonymous[Ser54Ser]
180 .. 180 A/G rs149866790 + CDS Nonsynonymous[Asp60Gly]
226 .. 226 G/A rs35348545 + CDS Synonymous[Glu75Glu]
298 .. 298 C/T rs149051207 + CDS Synonymous[Ile99Ile]
326 .. 326 C/T rs143150757 + CDS Nonsynonymous[Arg109Trp]
343 .. 343 C/A rs138820514 + CDS Synonymous[Ser114Ser]
360 .. 360 T/A rs202067893 + CDS Nonsynonymous[Leu120Gln]
368 .. 368 G/A rs199644323 + CDS Nonsynonymous[Ala123Thr]
371 .. 371 G/A rs141491899 + CDS Nonsynonymous[Ala124Thr]
373 .. 373 A/T rs147011573 + CDS Synonymous[Ala124Ala]
415 .. 415 G/C rs200106330 + CDS Synonymous[Pro138Pro]
416 .. 416 A/T rs138170411 + CDS Nonsynonymous[Thr139Ser]
418 .. 418 G/A rs141848502 + CDS Synonymous[Thr139Thr]
419 .. 419 G/A rs150608077 + CDS Nonsynonymous[Gly140Ser]
425 .. 425 T/G rs138834913 + CDS Nonsynonymous[Phe142Val]
449 .. 449 G/A rs149372771 + CDS Nonsynonymous[Ala150Thr]
484 .. 484 G/A rs184104374 + CDS Synonymous[Lys161Lys]
522 .. 522 A/G rs146376009 + CDS Nonsynonymous[His174Arg]
524 .. 524 G/A rs142948956 + CDS Nonsynonymous[Gly175Ser]
529 .. 529 C/T rs139692565 + CDS Synonymous[Tyr176Tyr]
532 .. 532 C/T rs144351365 + CDS Synonymous[Ile177Ile]
534 .. 534 A/G rs114065146 + CDS Nonsynonymous[Asp178Gly]
536 .. 536 A/G rs74949017 + CDS Nonsynonymous[Lys179Glu]
576 .. 576 A/C rs202150098 + CDS Nonsynonymous[Tyr192Ser]
588 .. 588 G/A rs148787300 + CDS Nonsynonymous[Arg196Gln]
596 .. 596 T/G rs201672761 + CDS Nonsynonymous[Cys199Gly]
603 .. 603 G/A rs142521453 + CDS Nonsynonymous[Arg201His]
622 .. 622 C/T rs199810332 + CDS Synonymous[Phe207Phe]
660 .. 660 C/G rs150925091 + CDS Nonsynonymous[Ser220Cys]
670 .. 670 C/T rs140799215 + CDS Synonymous[Thr223Thr]
671 .. 671 G/A rs144305393 + CDS Nonsynonymous[Glu224Lys]
799 .. 799 G/A rs201343566 + CDS Synonymous[Leu266Leu]
822 .. 822 C/A rs147786310 + CDS Nonsynonymous[Ala274Asp]
874 .. 874 C/T rs2297192 + CDS Synonymous[Thr291Thr]
875 .. 875 G/A rs143965865 + CDS Nonsynonymous[Val292Met]
939 .. 939 A/T rs138218196 + CDS Nonsynonymous[His313Leu]
960 .. 960 G/T rs149106318 + CDS Nonsynonymous[Cys320Phe]
982 .. 982 G/A rs200776921 + CDS Synonymous[Glu327Glu]
1020 .. 1020 C/T rs77496669 + CDS Nonsynonymous[Ala340Val]
1021 .. 1021 G/A rs3814264 - CDS Synonymous[Ala340Ala]
1051 .. 1051 C/T rs10162257 + CDS Synonymous[Ile350Ile]
1068 .. 1068 A/G rs141493325 + CDS Nonsynonymous[His356Arg]
1075 .. 1075 G/C rs146333822 + CDS Nonsynonymous[Glu358Asp]
1081 .. 1081 G/A rs138274623 + CDS Synonymous[Leu360Leu]
1091 .. 1091 C/G rs200960110 + CDS Nonsynonymous[Leu364Val]
1095 .. 1095 C/G rs142970403 + CDS Nonsynonymous[Ala365Gly]
1124 .. 1124 G/A rs146112954 + CDS Nonsynonymous[Val375Met]
1128 .. 1128 A/G rs140013835 + CDS Nonsynonymous[Glu376Gly]
1137 .. 1137 G/A rs201067980 + CDS Nonsynonymous[Arg379Gln]
1153 .. 1153 C/T rs149849745 + CDS Synonymous[Asp384Asp]
1156 .. 1156 C/T rs143909527 + CDS Synonymous[Gly385Gly]
1162 .. 1162 G/A rs148613247 + CDS Synonymous[Gln387Gln]
1167 .. 1167 T/C rs144161603 + CDS Nonsynonymous[Ile389Thr]
1173 .. 1173 A/G rs117508840 + CDS Nonsynonymous[Asn391Ser]
1174 .. 1174 C/G rs139530619 + CDS Nonsynonymous[Asn391Lys]
1184 .. 1184 G/A rs145260894 + CDS Nonsynonymous[Ala395Thr]
1185 .. 1185 C/T rs201603170 + CDS Nonsynonymous[Ala395Val]
1220 .. 1220 C/T rs74926660 + CDS Nonsynonymous[Arg407Trp]
1224 .. 1224 A/G rs140904230 + CDS Nonsynonymous[His408Arg]
1245 .. 1245 C/T rs142444839 + CDS Nonsynonymous[Ala415Val]
1246 .. 1246 G/C rs145592732 + CDS Synonymous[Ala415Ala]
1270 .. 1270 G/T rs7139812 + CDS Synonymous[Leu423Leu]
1295 .. 1295 C/A rs145619176 + CDS Nonsynonymous[Arg432Ser]
1296 .. 1296 G/A rs138339540 + CDS Nonsynonymous[Arg432His]
1299 .. 1299 G/A rs201412482 + CDS Nonsynonymous[Arg433His]
1301 .. 1301 C/T rs142834643 + CDS Synonymous[Leu434Leu]
1309 .. 1309 G/A rs145126289 + CDS Synonymous[Thr436Thr]
1358 .. 1358 G/A rs199856433 + CDS Nonsynonymous[Val453Met]
1426 .. 1426 C/T rs148350513 + CDS Synonymous[Thr475Thr]
1432 .. 1432 G/A rs141497667 + CDS Synonymous[Ala477Ala]
1456 .. 1456 C/G/T rs116760356 + CDS
1458 .. 1458 C/T rs151147187 + CDS Nonsynonymous[Ala486Val]
1475 .. 1475 G/A rs199990494 + CDS Nonsynonymous[Glu492Lys]
1496 .. 1496 C/T rs139393934 + CDS Nonsynonymous[Leu499Phe]
1507 .. 1507 C/T rs142710507 + CDS Synonymous[His502His]
1508 .. 1508 G/A rs149169648 + CDS Nonsynonymous[Val503Met]
1585 .. 1585 G/A rs147346793 + CDS Synonymous[Ala528Ala]
1671 .. 1671 G/A rs183892240 + CDS Nonsynonymous[Arg557Gln]
1675 .. 1675 C/T rs139596233 + CDS Synonymous[Gly558Gly]
1692 .. 1692 C/T rs145119738 + CDS Nonsynonymous[Ser564Phe]
1698 .. 1698 G/A rs145034791 + CDS Nonsynonymous[Gly566Asp]
1710 .. 1710 G/A rs200280099 + CDS Nonsynonymous[Arg570Gln]
1725 .. 1725 G/A rs200142815 + CDS Nonsynonymous[Arg575Gln]
1747 .. 1747 T/C rs138484551 + CDS Synonymous[Ser582Ser]
1754 .. 1754 C/T rs142144978 + CDS Nonsynonymous[Arg585Trp]
1765 .. 1765 C/T rs35155188 + CDS Synonymous[Arg588Arg]
1766 .. 1766 G/A rs140378410 + CDS Nonsynonymous[Gly589Ser]
1772 .. 1772 G/T rs11840035 + CDS Nonsynonymous[Ala591Ser]
1774 .. 1774 G/A rs145652555 + CDS Synonymous[Ala591Ala]
1849 .. 1849 C/T rs61752696 + CDS Synonymous[Tyr616Tyr]
1868 .. 1868 G/A rs146542168 + CDS Nonsynonymous[Val623Ile]
1915 .. 1915 C/A rs201634776 + CDS Nonsynonymous[His638Gln]
1939 .. 1939 C/G rs182260800 + CDS Nonsynonymous[Asn646Lys]
1975 .. 1975 C/T rs60429762 + CDS Synonymous[Ile658Ile]
2083 .. 2083 T/C rs2281723 - CDS Synonymous[Tyr694Tyr]
2087 .. 2087 A/C rs201890906 + CDS Nonsynonymous[Lys696Gln]
2137 .. 2137 C/T rs202173866 + CDS Synonymous[Ser712Ser]
2138 .. 2138 G/A rs150220613 + CDS Nonsynonymous[Asp713Asn]
2302 .. 2302 G/A rs186247935 + CDS Synonymous[Ala767Ala]
2338 .. 2338 C/T rs201172738 + CDS Synonymous[Asn779Asn]
2365 .. 2365 C/T rs137978862 + CDS Synonymous[Thr788Thr]
2386 .. 2386 C/T rs117189528 + CDS Synonymous[Gly795Gly]
2387 .. 2387 G/A rs143748702 + CDS Nonsynonymous[Asp796Asn]
2392 .. 2392 G/A rs201327114 + CDS Synonymous[Leu797Leu]
2416 .. 2416 A/G rs9604022 + CDS Synonymous[Ser805Ser]
2425 .. 2425 C/T rs144080077 + CDS Synonymous[Val808Val]
2455 .. 2455 G/A rs142879850 + CDS Synonymous[Lys818Lys]
2596 .. 2596 C/T rs150786675 + CDS Synonymous[Asn865Asn]
2612 .. 2612 A/G rs201162083 + CDS Nonsynonymous[Ile871Val]
2617 .. 2617 G/A rs139449890 + CDS Synonymous[Thr872Thr]
2624 .. 2624 G/A rs201499217 + CDS Nonsynonymous[Val875Met]
2663 .. 2663 G/A rs201538160 + CDS Nonsynonymous[Ala888Thr]
2681 .. 2681 A/G rs143370145 + CDS Nonsynonymous[Ile894Val]
2684 .. 2684 G/A rs199551610 + CDS Nonsynonymous[Val895Ile]
2716 .. 2716 G/A rs150538425 + CDS Synonymous[Ala905Ala]
2806 .. 2806 C/T rs139497556 + CDS Synonymous[Ser935Ser]
2812 .. 2812 C/T rs149724257 + CDS Synonymous[Pro937Pro]
2824 .. 2824 G/A rs144535397 + CDS Synonymous[Pro941Pro]
2899 .. 2899 C/T rs139444736 + CDS Synonymous[Ser966Ser]
2905 .. 2905 G/A rs144143917 + CDS Synonymous[Glu968Glu]
2908 .. 2908 A/T rs143456347 + CDS Synonymous[Gly969Gly]
2912 .. 2912 G/A/T rs72663547 + CDS
2938 .. 2938 C/T rs142256342 + CDS Synonymous[Pro979Pro]
2941 .. 2941 C/T rs202200419 + CDS Synonymous[Pro980Pro]
2942 .. 2942 G/A rs199888522 + CDS Nonsynonymous[Glu981Lys]
2975 .. 2975 T/C rs201634018 + CDS Nonsynonymous[Ser992Pro]
2995 .. 2995 C/T rs184014403 + CDS Synonymous[Asp998Asp]
2999 .. 2999 G/A rs12429945 + CDS Nonsynonymous[Gly1000Arg]
3152 .. 3152 G/A rs182853129 + CDS Nonsynonymous[Val1051Met]
3178 .. 3178 C/T rs201046729 + CDS Synonymous[Asp1059Asp]
3231 .. 3231 C/G rs140657264 + CDS Nonsynonymous[Pro1077Arg]
3307 .. 3307 G/A rs144616060 + CDS Synonymous[Gly1102Gly]
3411 .. 3411 T/A rs117305892 + 3'UTR
3481 .. 3481 G/C rs2480951 + 3'UTR
3481 ^ 3482 -/G rs199507106 + 3'UTR
3482 .. 3482 A/T rs138738375 + 3'UTR
3547 .. 3547 A/G rs2476320 + 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene;  Repeat mask viewerRepeat Mask Viewer