H-InvDB x AHG DB
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H-Invitational ID: HIT000492598 Accession number: AK297974 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Cyclin-dependent kinase 14; EC=2.7.11.22; Cell division protein kinase 14; Serine/threonine-protein kinase PFTAIRE-1; hPFTAIRE1;
 
 

Transcript original information
Accession number AK297974.1
CAGE tag ID NA
EST ID NA
Clone Number HHDPC2007572
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (CLDN12) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (CLDN12);
Sequence data provider NA
Annotation project NA
Length of cDNA 2014[bp] (No. of exon:15)[A:559 T:497 G:479 C:479]
Devision HUM
Molecular type mRNA
Library origin Cell type dermal papilla cells (HDPC)
Tissue type NA
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0006831
Genomic location  G-integra Help Chromosome 7
Location 7q21.13
Position 90225720- 90836833
Strand +
Possible duplicated location(s) NA
Gene structure 15 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:5218
KEGG GENES KEGG GENES(5218)
GeneCard GeneCardCLDN12*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000251919
Predicted CDS 223..1632;  469[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.738

Motif information
ORF

length(469),orf(223:1632)
MCDLIEPRPAEKIGKMKKLRRTLSESFSRIALKKDDTTFDEICVTKMSTR
NCQGMDSVIKPLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNAC
INFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVY
KGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDII
HTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQR
YILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPP
DVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLG
TPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLL
QCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGES
MRAFGKNNSYGKSLSNSKH*
a.a.
length
InterPro Name
length(294), motif(131:424) 294 IPR011009 Protein kinase-like domain [Domain]
length(285), motif(135:419) 285 IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain [Domain]
length(285), motif(135:419) 285 IPR000719 Protein kinase domain [Domain]
length(24), motif(141:164) 24 IPR017441 Protein kinase, ATP binding site [Binding_site]
length(13), motif(252:264) 13 IPR008271 Serine/threonine-protein kinase, active site [Active_site]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000492598
H-Inv cluster ID Locus viewHIX0006831
Accession number AK297974.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO; 
Coding potential  Help Protein coding; 
Definition Cyclin-dependent kinase 14; EC=2.7.11.22; Cell division protein kinase 14; Serine/threonine-protein kinase PFTAIRE-1; hPFTAIRE1;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (O94921)  [Identity/coverage = 99.787%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 100484851131314312098780126902051285394814702039154893341646146716775625173448461751762218691976193691951952457120059949ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol CLDN12
HGNC aliases NA
HGNC name claudin 12
DDBJ NA
UniProt CDK14
EC number EC 2.7.11.22cyclin-dependent kinase; 
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway 04360 :Axon guidance;  04530 :Tight junction;  04540 :Gap junction;  04660 :T cell receptor signaling pathway; 
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000251919
No. of interaction 1
Interaction partner(s) HIP000043732
BIND NA
DIP NA
MINT MINT-7147585;  MINT-7147598;  MINT-7147614;  MINT-7147628;  MINT-7147647;  MINT-7147665;  MINT-7147680;  MINT-7147695;  MINT-7147713;  MINT-7147725;  MINT-7147743; 
HPRD 00215;  00298;  00886;  03184;  05457; 
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:5218
KEGG GENES KEGG GENES(5218)
GeneCard GeneCardCLDN12*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function transferase activity, transferring phosphorus-containing groups (GO:0016772);  ATP binding (GO:0005524);  protein kinase activity (GO:0004672); 
Biological process protein amino acid phosphorylation (GO:0006468); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT nuclear;  cytosol; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
56 423 1nw1A 1e-39 8.1 335/365 d.144.1.8
Related H-InvDB links GTOP GTOP

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
34 .. 34 G/T rs35275033 + 5'UTR
87 .. 87 C/A rs34052294 + 5'UTR
111 .. 111 G/A rs11760706 + 5'UTR
209 .. 209 C/T rs7782773 + 5'UTR
317 .. 317 T/G rs192282583 + CDS Nonsynonymous[Leu32Trp]
335 .. 335 C/G rs17866277 + CDS Nonsynonymous[Thr38Ser]
371 .. 371 G/A rs140679817 + CDS Nonsynonymous[Arg50Gln]
405 .. 405 C/T rs144891494 + CDS Synonymous[Pro61Pro]
575 .. 575 A/G rs187133761 + CDS Nonsynonymous[His118Arg]
581 .. 581 G/A rs138436598 + CDS Nonsynonymous[Ser120Asn]
591 .. 591 G/A rs55722725 + CDS Synonymous[Ser123Ser]
665 .. 665 C/T rs148988868 + CDS Nonsynonymous[Thr148Ile]
669 .. 669 A/G rs145790847 + CDS Synonymous[Val149Val]
678 .. 678 G/A rs200795779 + CDS Synonymous[Gly152Gly]
741 .. 741 G/A rs138497570 + CDS Synonymous[Gly173Gly]
750 .. 750 C/T rs78919227 + CDS Synonymous[Phe176Phe]
799 .. 799 A/G rs146138173 + CDS Nonsynonymous[Ile193Val]
837 .. 837 G/A rs56269509 + CDS Synonymous[Thr205Thr]
903 .. 903 G/A/T rs55664580 + CDS
906 .. 906 G/A rs184702498 + CDS Synonymous[Leu228Leu]
918 .. 918 T/C rs141395840 + CDS Synonymous[Asn232Asn]
956 .. 956 C/G rs150860380 + CDS Nonsynonymous[Ser245Cys]
1005 .. 1005 C/T rs139294759 + CDS Synonymous[Asn261Asn]
1047 .. 1047 C/T rs202149959 + CDS Synonymous[Phe275Phe]
1068 .. 1068 C/T rs201386540 + CDS Synonymous[Ser282Ser]
1091 .. 1091 A/G rs202143669 + CDS Nonsynonymous[Asn290Ser]
1093 .. 1093 G/A rs144455762 + CDS Nonsynonymous[Glu291Lys]
1105 .. 1105 T/C rs147407359 + CDS Synonymous[Leu295Leu]
1144 .. 1144 G/C rs201692399 + CDS Nonsynonymous[Glu308Gln]
1251 .. 1251 A/G rs112955689 + CDS Synonymous[Glu343Glu]
1253 .. 1253 G/A rs139618090 + CDS Nonsynonymous[Arg344Gln]
1280 .. 1280 A/G rs145309096 + CDS Nonsynonymous[Asn353Ser]
1296 .. 1296 T/C rs199729119 + CDS Synonymous[Pro358Pro]
1357 .. 1357 C/T rs34419285 + CDS Nonsynonymous[Leu379Phe]
1358 .. 1358 T/G rs145058405 + CDS Nonsynonymous[Leu379Arg]
1385 .. 1385 A/G rs149042459 + CDS Nonsynonymous[Tyr388Cys]
1396 .. 1396 G/A rs112642464 + CDS Nonsynonymous[Ala392Thr]
1401 .. 1401 G/A rs114347546 + CDS Synonymous[Glu393Glu]
1449 .. 1449 G/A rs151182341 + CDS Synonymous[Ser409Ser]
1470 .. 1470 C/T rs56412135 + CDS Synonymous[His416His]
1495 .. 1495 C/G rs140184613 + CDS Nonsynonymous[Arg425Gly]
1498 .. 1498 C/G rs200612683 + CDS Nonsynonymous[Leu426Val]
1576 .. 1576 C/T rs145303395 + CDS Nonsynonymous[Arg452Trp]
1577 .. 1577 G/A rs74839397 + CDS Nonsynonymous[Arg452Gln]
1609 .. 1609 A/C rs35643773 + CDS Nonsynonymous[Ser463Arg]
1612 .. 1612 C/G rs199515743 + CDS Nonsynonymous[Leu464Val]
1622 .. 1622 G/A rs141334351 + CDS Nonsynonymous[Ser467Asn]
1651 .. 1651 G/T rs192554076 + 3'UTR
1824 .. 1824 C/T rs12538034 + 3'UTR
1896 .. 1896 G/A rs186946911 + 3'UTR
1901 .. 1901 T/C rs117606486 + 3'UTR
1956 .. 1956 G/A rs79425377 + 3'UTR
1996 .. 1996 A/- rs57373891 + 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer