H-InvDB_9.0 released on May 27, 2015. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

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H-Invitational ID: HIT000492598 Accession number: AK297974 Created date: 26-Mar-2013 Last modified: 27-May-2015 Definition: Cyclin-dependent kinase 14; EC=2.7.11.22; Cell division protein kinase 14; Serine/threonine-protein kinase PFTAIRE-1; hPFTAIRE1;

		Select format Flat file XML file Nucleotide sequence fasta Protein sequence fasta

Transcript original information Accession number AK297974.1 CAGE tag ID NA EST ID NA Clone Number HHDPC2007572 Experimental resources   NBRC ; HGPD ; Antibody (CLDN12) ; Catalog (CLDN12); Sequence data provider NA Annotation project NA Length of cDNA 2014[bp] (No. of exon:15)[A:559 T:497 G:479 C:479] Devision HUM Molecular type mRNA Library origin Cell type dermal papilla cells (HDPC) Tissue type NA Develpmental stage NA

Sequence quality information CDS feature Complete CDS Kozak sequence NA PolyA NA Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) NA Transcript quality feature NA Notes NA

GTAAACCGCCCCCGCCCGCCCAGCTGCGGCCCAGGCCGGAGCGGAGCCTG CCGTCCTCCGCCTGCCTGCTGCTCGCCTCCCTAGACCTGCGCGTCGCTTC CCGGCCCGCCGAGGAGGTGGTGGAGGAGGAGGCGCCGCTTTCCCCGCGGC GCGCGCCCTCGCCGTTGTCTGAGCTGTGCCTGGACCAGTTTGGGGAAGTT GTCGGGGCCCCGCGTCGCCCAGATGTGTGACCTCATTGAGCCGCGGCCGG CCGAGAAGATCGGCAAGATGAAGAAGTTGCGGAGAACTTTGTCGGAGAGT TTCAGTCGCATTGCTTTGAAGAAAGATGACACCACCTTTGATGAGATATG TGTCACAAAGATGTCTACACGGAACTGCCAGGGAATGGACTCAGTGATCA AACCCCTGGACACAATTCCTGAGGATAAAAAAGTCAGAGTTCAGAGGACA CAGAGCACTTTTGACCCATTTGAGAAACCAGCTAATCAAGTAAAGAGGGT GCATTCTGAGAACAATGCTTGCATTAACTTTAAGACCTCCTCCACTGGCA AAGAGTCACCTAAAGTTAGGCGGCACTCCAGCCCCAGCTCGCCAACAAGT CCCAAATTTGGAAAAGCTGACTCATATGAAAAGCTGGAAAAACTAGGGGA AGGATCTTATGCTACAGTATACAAAGGGAAAAGCAAGGTAAATGGGAAGT TGGTAGCTCTGAAGGTGATCAGGCTGCAGGAAGAAGAAGGGACACCTTTC ACAGCTATCAGGGAAGCTTCTCTTTTAAAAGGACTAAAACATGCTAACAT AGTGCTACTTCATGACATCATCCATACCAAGGAGACGCTGACACTTGTGT TTGAATATGTGCACACTGATTTATGTCAGTACATGGACAAGCACCCTGGG GGGCTGCATCCAGATAATGTGAAGTTGTTTTTATTTCAGTTGCTGCGAGG TCTGTCTTACATCCACCAGCGTTATATTTTGCACAGAGACCTGAAACCAC AGAACCTTCTGATCAGTGACACGGGGGAGTTAAAGCTGGCAGATTTCGGT CTTGCAAGAGCAAAATCCGTCCCTAGCCACACATACTCCAACGAAGTGGT TACCTTGTGGTACAGACCTCCAGATGTCCTTCTAGGCTCAACAGAATATT CCACCTGCCTTGACATGTGGGGAGTAGGTTGCATCTTTGTTGAAATGATC CAAGGAGTTGCTGCTTTTCCAGGAATGAAAGACATTCAGGATCAACTTGA ACGAATATTTCTGGTTCTTGGAACACCAAATGAGGACACATGGCCTGGAG TTCATTCTTTACCACATTTTAAGCCAGAACGCTTTACCCTGTACAGCTCT AAAAACCTTAGACAAGCATGGAATAAGCTCAGCTATGTGAACCATGCAGA GGACCTGGCCTCCAAGCTCCTACAATGTTCCCCAAAGAACAGACTGTCGG CACAGGCTGCCTTGAGCCACGAGTATTTTAGTGACCTGCCGCCACGGCTA TGGGAACTCACCGACATGTCTTCTATTTTTACTGTCCCAAATGTGAGATT GCAACCAGAAGCTGGAGAAAGCATGCGGGCCTTTGGGAAAAACAATAGTT ATGGCAAAAGTCTATCAAACAGCAAGCACTGACAAGCAGCACATTCTCAA GAGCACACAGGATTAAGTTGTCATCATTCTGGGAAGGAAAAAAAAACATT AATGAAGAGGCCAATAATATGAAGGGAATCATGGATCAGTTTTCTTTCGC TCCCTGTGGTGGATTTCACTTACAAGAAAATTGAAGCTGGCAAGACCCTG TTTTCTCTGCAATTTATTTAAAACCTTGCACGCATTTGGATACCTTGTGA TTTCCAAGAACTACGTGAAGATTAAGCTTTGCTTACTGATACATGGCATG TATTCTTTTCAGTCTTTTGTGTTTGATTTTGTTTGATTTCCCTCTGCAGC ACAGCGTCTCTGTAAAGGTTTTTATGCTTTCACCAGCCATGTCTTAAATA CATTAAGACAACAC

Gene structure information

H-Inv cluster ID		HIX0006831
Genomic location	Chromosome	7
	Location	7q21.13
	Position	90225720- 90836833
	Strand	+
Possible duplicated location(s)		NA
Gene structure		15 exon(s)
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:5218;
	KEGG GENES	KEGG GENES(5218);
	GeneCard	CLDN12;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000251919 Predicted CDS 223..1632;  469[aa];  Orientation:+1;  Codon Adaptation Index (CAI). 0.738

MCDLIEPRPAEKIGKMKKLRRTLSESFSRIALKKDDTTFDEICVTKMSTR NCQGMDSVIKPLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNAC INFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVY KGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDII HTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQR YILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPP DVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLG TPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLL QCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGES MRAFGKNNSYGKSLSNSKH*

Motif information

	a.a. length	InterPro	Name
	294	IPR011009	Protein kinase-like domain [Domain]
	285	IPR002290	Serine/threonine/dual specificity protein kinase, catalytic domain [Domain]
	285	IPR000719	Protein kinase domain [Domain]
	24	IPR017441	Protein kinase, ATP binding site [Binding_site]
	13	IPR008271	Serine/threonine-protein kinase, active site [Active_site]

Gene function information

H-Inv ID		HIT000492598
H-Inv cluster ID		HIX0006831
Accession number		AK297974.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		NO;
Coding potential		Protein coding;
Definition		Cyclin-dependent kinase 14; EC=2.7.11.22; Cell division protein kinase 14; Serine/threonine-protein kinase PFTAIRE-1; hPFTAIRE1;
Similarity category		Category: Identical to known human protein(Category I).
		Identical to known human protein (O94921)  [Identity/coverage = 99.787%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence		Protein evidence
PubMed ID		10048485;  11313143;  12098780;  12690205;  12853948;  14702039;  15489334;  16461467;  16775625;  17344846;  17517622;  18691976;  19369195;  19524571;  20059949;  ALL;
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	CLDN12
	HGNC aliases	NA
	HGNC name	claudin 12
	DDBJ	NA
	UniProt	CDK14
EC number		EC 2.7.11.22cyclin-dependent kinase;
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		04360 :Axon guidance;  04530 :Tight junction;  04540 :Gap junction;  04660 :T cell receptor signaling pathway;
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000251919
	No. of interaction	1
	Interaction partner(s)	HIP000043732;
	BIND	NA
	DIP	NA
	MINT	MINT-7147585;  MINT-7147598;  MINT-7147614;  MINT-7147628;  MINT-7147647;  MINT-7147665;  MINT-7147680;  MINT-7147695;  MINT-7147713;  MINT-7147725;  MINT-7147743;
	HPRD	00215;  00298;  00886;  03184;  05457;
	IntAct	NA
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:5218;
	KEGG GENES	KEGG GENES(5218);
	GeneCard	CLDN12;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Auto-annotated
Notes		NA
Related H-InvDB links		Gene family;  Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Molecular function	transferase activity, transferring phosphorus-containing groups (GO:0016772);  ATP binding (GO:0005524);  protein kinase activity (GO:0004672);
Biological process	protein amino acid phosphorylation (GO:0006468);

Subcellular localization information

Last modified:27-May-2015

WoLF PSORT	nuclear;  cytosol;
Target P	Other
SOSUI	soluble protein
TMHMM	soluble protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified:27-May-2015

Start End PDB_ID E-value Identity Coverage SCOP_ID 56 423 1nw1A 1e-39 8.1 335/365 d.144.1.8

Related H-InvDB links GTOP

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 34 .. 34 G/T rs35275033 + 5'UTR 87 .. 87 C/A rs34052294 + 5'UTR 111 .. 111 G/A rs11760706 + 5'UTR 209 .. 209 C/T rs7782773 + 5'UTR 317 .. 317 T/G rs192282583 + CDS Nonsynonymous[Leu32Trp] 335 .. 335 C/G rs17866277 + CDS Nonsynonymous[Thr38Ser] 371 .. 371 G/A rs140679817 + CDS Nonsynonymous[Arg50Gln] 405 .. 405 C/T rs144891494 + CDS Synonymous[Pro61Pro] 575 .. 575 A/G rs187133761 + CDS Nonsynonymous[His118Arg] 581 .. 581 G/A rs138436598 + CDS Nonsynonymous[Ser120Asn] 591 .. 591 G/A rs55722725 + CDS Synonymous[Ser123Ser] 665 .. 665 C/T rs148988868 + CDS Nonsynonymous[Thr148Ile] 669 .. 669 A/G rs145790847 + CDS Synonymous[Val149Val] 678 .. 678 G/A rs200795779 + CDS Synonymous[Gly152Gly] 741 .. 741 G/A rs138497570 + CDS Synonymous[Gly173Gly] 750 .. 750 C/T rs78919227 + CDS Synonymous[Phe176Phe] 799 .. 799 A/G rs146138173 + CDS Nonsynonymous[Ile193Val] 837 .. 837 G/A rs56269509 + CDS Synonymous[Thr205Thr] 903 .. 903 G/A/T rs55664580 + CDS 906 .. 906 G/A rs184702498 + CDS Synonymous[Leu228Leu] 918 .. 918 T/C rs141395840 + CDS Synonymous[Asn232Asn] 956 .. 956 C/G rs150860380 + CDS Nonsynonymous[Ser245Cys] 1005 .. 1005 C/T rs139294759 + CDS Synonymous[Asn261Asn] 1047 .. 1047 C/T rs202149959 + CDS Synonymous[Phe275Phe] 1068 .. 1068 C/T rs201386540 + CDS Synonymous[Ser282Ser] 1091 .. 1091 A/G rs202143669 + CDS Nonsynonymous[Asn290Ser] 1093 .. 1093 G/A rs144455762 + CDS Nonsynonymous[Glu291Lys] 1105 .. 1105 T/C rs147407359 + CDS Synonymous[Leu295Leu] 1144 .. 1144 G/C rs201692399 + CDS Nonsynonymous[Glu308Gln] 1251 .. 1251 A/G rs112955689 + CDS Synonymous[Glu343Glu] 1253 .. 1253 G/A rs139618090 + CDS Nonsynonymous[Arg344Gln] 1280 .. 1280 A/G rs145309096 + CDS Nonsynonymous[Asn353Ser] 1296 .. 1296 T/C rs199729119 + CDS Synonymous[Pro358Pro] 1357 .. 1357 C/T rs34419285 + CDS Nonsynonymous[Leu379Phe] 1358 .. 1358 T/G rs145058405 + CDS Nonsynonymous[Leu379Arg] 1385 .. 1385 A/G rs149042459 + CDS Nonsynonymous[Tyr388Cys] 1396 .. 1396 G/A rs112642464 + CDS Nonsynonymous[Ala392Thr] 1401 .. 1401 G/A rs114347546 + CDS Synonymous[Glu393Glu] 1449 .. 1449 G/A rs151182341 + CDS Synonymous[Ser409Ser] 1470 .. 1470 C/T rs56412135 + CDS Synonymous[His416His] 1495 .. 1495 C/G rs140184613 + CDS Nonsynonymous[Arg425Gly] 1498 .. 1498 C/G rs200612683 + CDS Nonsynonymous[Leu426Val] 1576 .. 1576 C/T rs145303395 + CDS Nonsynonymous[Arg452Trp] 1577 .. 1577 G/A rs74839397 + CDS Nonsynonymous[Arg452Gln] 1609 .. 1609 A/C rs35643773 + CDS Nonsynonymous[Ser463Arg] 1612 .. 1612 C/G rs199515743 + CDS Nonsynonymous[Leu464Val] 1622 .. 1622 G/A rs141334351 + CDS Nonsynonymous[Ser467Asn] 1651 .. 1651 G/T rs192554076 + 3'UTR 1824 .. 1824 C/T rs12538034 + 3'UTR 1896 .. 1896 G/A rs186946911 + 3'UTR 1901 .. 1901 T/C rs117606486 + 3'UTR 1956 .. 1956 G/A rs79425377 + 3'UTR 1996 .. 1996 A/- rs57373891 + 3'UTR  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  No data available Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;