H-InvDB_9.0 released on May 27, 2015. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

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H-Invitational ID: HIT000493450 Accession number: AK298826 Created date: 26-Mar-2013 Last modified: 27-May-2015 Definition: Similar to Nuclear valosin-containing protein-like isoform 2.

		Select format Flat file XML file Nucleotide sequence fasta Protein sequence fasta

Transcript original information Accession number AK298826.1 CAGE tag ID NA EST ID NA Clone Number NT2NE2009164 Experimental resources   NBRC ; HGPD ; Antibody (NVL) ; Catalog (NVL); Sequence data provider NA Annotation project NA Length of cDNA 2295[bp] (No. of exon:19)[A:709 T:544 G:567 C:475] Devision HUM Molecular type mRNA Library origin Cell type teratocarcinoma Tissue type NA Develpmental stage NA

Sequence quality information CDS feature Complete CDS Kozak sequence NA PolyA NA Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) TAGGAG;  Transcript quality feature NMD predicted;  Truncation;  Notes NA

GAAAGACCGACGCGATGAAGCCCAGACCTGCAGGGTTCGTGGATAATAAA CTCAAGCAGCGAGTCATCCAGTATAGACTATGGTCGAAGAAAAAGAAATG CTTTTAGGATTCAGGTAGAAAAAGTATTTAGCATAATTAGTAGTGAGAAG GAACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGGC AAGACAAGGTGAAGAGGATAATGAGTATACTGAAAGCTATTCTGATGATG ATTCAAGTATGGAAGACTACCCAGATCCACAGTCAGCAAATCACATGAAC AGTTCCCTGCTGTCTTTATATCGGAAAGGAAATCCTGATTCTGTTTCAAA TACTCCTGAGATGGAGCAAAGAGAAACCACCTCTTCAACACCACGAATAA GTTCCAAAACAGGCTCCATTCCCTTGAAGACCCCTGCCAAAGATTCTGAA GGAGGATGGTTTATTGACAAAACCCCAAGTGTAAAGAAAGACAGTTTTTT CTTGGACCTGTCATGTGAGAAAAGTAATCCTAAGAAGCCAATAACTGAGA TACAGGATTCAAAAGATTCTTCTCTTTTGGAGAGTGATATGAAACGGAAA GGCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGA AGTAGATGGAGAAATTGAAGCTGTCCTACAAAAGAAAGCTAAAGCCAGGG GGTTAGAATTCCAGATCTCCAACGTGAAGTTTGAAGATGTGGGAGGCAAT GATATGACATTAAAAGAGGTCTGCAAGATGCTCATACACATGCGTCACCC GGAGGTGTACCACCACCTGGGCGTCGTGCCCCCTCGTGGAGTTCTCCTTC ATGGACCACCAGGCTGTGGGAAGACATTACTTGCACATGCAATTGCTGGG GAACTTGACCTGCCAATTTTGAAAGTGGCTGCTCCAGAGATTGTGTCTGG AGTATCCGGAGAGTCTGAGCAGAAGCTGAGAGAACTATTTGAGCAAGCTG TGTCAAATGCACCATGTATCATTTTCATTGATGAAATTGATGCTATTACC CCCAAAAGAGAAGTGGCTTCAAAAGATATGGAACGAAGAATTGTAGCCCA ACTCCTAACCTGCATGGATGATCTGAATAATGTGGCTGCTACAGCCCGGG TCCTAGTTATTGGAGCTACTAATCGACCAGACTCGTTAGACCCTGCTTTG AGACGTGCGGGAAGGTTCGACCGAGAAATATGCCTAGGTATCCCAGATGA AGCATCCAGGGAAAGAATACTTCAAACATTGTGCAGAAAACTGAGGCTTC CTCAAGCTTTTGATTTCTGTCACTTAGCACACCTAACTCCAGGCTTTGTT GGTGCTGATCTCATGGCACTGTGCCGAGAGGCAGCAATGTGTGCAGTCAA TAGAGTCTTAATGAAGCTACAGGAACAGCAGAAGAAAAATCCTGAAATGG AAGATTTGCCATCTAAAGGAGTCCAGGAGGAAAGGCTGGGAACTGAGCCC ACTTCTGAAACACAGGATGAATTACAAAGGCTGCTGGGGTTGCTAAGAGA CCAAGATCCCCTCTCAGAGGAGCAGATGCAAGGACTGTGCATTGAACTGA ATGATTTCATTGTTGCTCTATCCTCAGTCCAACCCTCTGCCAAAAGGGAA GGCTTTGTCACTGTCCCTAATGTGACATGGGCAGATATTGGTGCCCTGGA AGACATTAGAGAGGAGCTCACCATGGCAATATTGGCACCAGTACGCAACC CAGACCCGTTCAAAGCTCTTGGATTGGTGACTCCAGCTGGGGTCCTCCTT GCTGGTCCTCCTGGCTGTGGGAAGACTCTGCTGGCGAAGGCTGTTGCAAA TGAGTCCGGACTAAATTTTATATCTGTCAAGGGCCCCGAATTACTAAACA TGTATGTTGGTGAGAGTGAACGTGCTGTGCGACAAGTTTTTCAACGAGCC AAGAACTCAGCACCCTGTGTGATATTCTTTGATGAAGTGGATGCTTTATG TCCTCGAAGATCAGACCGAGAGATATAATTGACCCTGCAATCCTGCGCCC GGGCCGCCTGGACAAAACACTGTTTGTGGGTTTACCGCCCCCTGCAGATC GCCTTGCCATCTTAAAAACTATCACAAAAAATGGTACCAAACCACCACTG GATGCAGATGTAAATTTGGAAGCAATTGCTGGTGACCTTCGCTGTGATTG CTATACGGGCGCAGATCTCTCTGCTTTGGTACGAGAAGCTTCTATCTGTG CCCTGAGACAGGAAATGGCAAGACAGAAGAGTGGAGATGAAAAAG

Gene structure information

H-Inv cluster ID		HIX0001627
Genomic location	Chromosome	1
	Location	1q42.11
	Position	224420903- 224517843
	Strand	-
Possible duplicated location(s)		NA
Gene structure		19 exon(s)
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:4931;
	KEGG GENES	KEGG GENES(4931);
	GeneCard	NVL;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000252655 Predicted CDS 259..2028;  589[aa];  Orientation:+1;  Codon Adaptation Index (CAI). 0.702

MEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSK TGSIPLKTPAKDSEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQD SKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLE FQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGP PGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSN APCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLV IGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQA FDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDL PSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDF IVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDP FKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYV GESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDREI*

Motif information

	a.a. length	InterPro	Name
	230	IPR027417	P-loop containing nucleoside triphosphate hydrolase [Domain]
	315	IPR027417	P-loop containing nucleoside triphosphate hydrolase [Domain]
	140	IPR003593	AAA+ ATPase domain [Domain]
	132	IPR003959	ATPase, AAA-type, core [Domain]
	19	IPR003960	ATPase, AAA-type, conserved site [Conserved_site]
	115	IPR027417	P-loop containing nucleoside triphosphate hydrolase [Domain]
	115	IPR027417	P-loop containing nucleoside triphosphate hydrolase [Domain]
	80	IPR003593	AAA+ ATPase domain [Domain]
	74	IPR003959	ATPase, AAA-type, core [Domain]

Gene function information

H-Inv ID		HIT000493450
H-Inv cluster ID		HIX0001627
Accession number		AK298826.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		NO;
Coding potential		Protein coding;
Definition		Similar to Nuclear valosin-containing protein-like isoform 2.
Similarity category		Category: Similar to known protein(Category II).
		Similar to known protein (NP_996671)  [Identity/coverage = 99.705%/94.93%] to Homo sapiens protein.
Experimental evidence		Protein evidence
PubMed ID		NA
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	NVL
	HGNC aliases	NA
	HGNC name	nuclear VCP-like
	DDBJ	NA
	UniProt	NA
EC number		NA
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000252655
	No. of interaction	NA
	Interaction partner(s)	NA
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	NA
	IntAct	NA
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:4931;
	KEGG GENES	KEGG GENES(4931);
	GeneCard	NVL;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Auto-annotated
Notes		NA
Related H-InvDB links		Gene family;  Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Molecular function	ATP binding (GO:0005524);

Subcellular localization information

Last modified:27-May-2015

WoLF PSORT	cytosol;  nuclear;  plasma membrane;  Other;
Target P	Other
SOSUI	soluble protein
TMHMM	soluble protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified:27-May-2015

Start End PDB_ID E-value Identity Coverage SCOP_ID 156 393 1oz4A2 1e-38 49.8 235/270 c.37.1.20 443 585 1qhbA 2e-25 8.5 142/595 a.111.1.2

Related H-InvDB links GTOP

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 2 .. 2 A/G rs2896990 + 5'UTR 22 .. 22 C/T/G rs138268824 - 5'UTR 34 .. 34 G/A rs150333766 - 5'UTR 54 .. 54 A/T rs185167238 - 5'UTR 136 .. 136 A/G rs188734539 - 5'UTR 159 .. 159 G/T rs148207074 - 5'UTR 180 .. 180 T/G rs200417559 - 5'UTR 251 .. 251 A/G rs141925881 - 5'UTR 288 .. 288 A/T rs145284132 - CDS Synonymous[Ala10Ala] 303 .. 303 T/C rs146647214 - CDS Synonymous[Ser15Ser] 322 .. 322 C/G rs200984793 - CDS Nonsynonymous[Arg22Gly] 323 .. 323 G/A rs149707008 - CDS Nonsynonymous[Arg22Gln] 335 .. 335 C/T rs144983418 - CDS Nonsynonymous[Pro26Leu] 343 .. 343 G/A rs200499785 - CDS Nonsynonymous[Val29Ile] 353 .. 353 C/T rs188779693 - CDS Nonsynonymous[Thr32Ile] 380 .. 380 C/G rs182870329 - CDS Nonsynonymous[Thr41Ser] 395 .. 395 G/A rs61729123 - CDS Nonsynonymous[Arg46Gln] 396 .. 396 A/G rs7534447 - CDS Synonymous[Arg46Arg] 541 .. 541 A/G rs35056350 - CDS Nonsynonymous[Ile95Val] 550 .. 550 A/G rs35095827 - CDS Nonsynonymous[Ile98Val] 595 .. 595 C/T rs185890200 - CDS Nonsynonymous[Arg113Trp] 604 .. 604 A/C rs201576372 - CDS Nonsynonymous[Lys116Gln] 641 .. 641 A/T rs138739288 - CDS Nonsynonymous[Asp128Val] 678 .. 678 A/G rs3754090 + CDS Synonymous[Leu140Leu] 680 .. 680 A/G rs116571578 - CDS Nonsynonymous[Gln141Arg] 724 .. 724 G/A rs202032588 - CDS Nonsynonymous[Val156Met] 744 .. 744 A/G rs142174769 - CDS Synonymous[Gly162Gly] 746 .. 746 G/A rs149082458 - CDS Nonsynonymous[Gly163Asp] 754 .. 754 A/G rs184833826 - CDS Nonsynonymous[Met166Val] 794 .. 794 G/A rs143693597 - CDS Nonsynonymous[Arg179His] 801 .. 801 G/A rs192990289 - CDS Synonymous[Pro181Pro] 814 .. 814 C/T rs146061915 - CDS Nonsynonymous[His186Tyr] 823 .. 823 G/A rs12084919 - CDS Nonsynonymous[Val189Ile] 887 .. 887 A/G rs142913195 - CDS Nonsynonymous[His210Arg] 903 .. 903 A/G rs143535962 - CDS Synonymous[Glu215Glu] 932 .. 932 C/G rs201749970 - CDS Nonsynonymous[Ala225Gly] 951 .. 951 A/G rs16846339 - CDS Synonymous[Gly231Gly] 957 .. 957 C/T rs143457273 - CDS Synonymous[Ser233Ser] 971 .. 971 A/G rs138668303 - CDS Nonsynonymous[Gln238Arg] 1010 .. 1010 C/T rs146483979 - CDS Nonsynonymous[Ala251Val] 1020 .. 1020 C/T rs202040245 - CDS Synonymous[Ile254Ile] 1045 .. 1045 A/G rs199859247 - CDS Nonsynonymous[Ile263Val] 1147 ^ 1148 -/C rs34955143 - CDS 1149 .. 1149 G/T rs201587242 - CDS Synonymous[Arg297Arg] 1150 .. 1150 G/A rs34631151 - CDS Nonsynonymous[Val298Ile] 1182 .. 1182 C/T rs142809512 - CDS Synonymous[Asp308Asp] 1185 .. 1185 G/A rs149850559 - CDS Synonymous[Ser309Ser] 1187 .. 1187 T/G rs201713614 - CDS AA-STOP[Leu310*] 1209 .. 1209 G/A rs147300158 - CDS Synonymous[Ala317Ala] 1354 .. 1354 G/T rs112890149 - CDS Nonsynonymous[Ala366Ser] 1391 .. 1391 G/A rs199638209 - CDS Nonsynonymous[Cys378Tyr] 1398 .. 1398 C/T rs200507325 - CDS Synonymous[Val380Val] 1442 .. 1442 C/G rs139575589 - CDS Nonsynonymous[Pro395Arg] 1472 .. 1472 T/G rs200066624 - CDS Nonsynonymous[Val405Gly] 1485 .. 1485 G/C rs141166869 - CDS Nonsynonymous[Arg409Ser] 1501 .. 1501 A/G rs201616896 - CDS Nonsynonymous[Thr415Ala] 1541 .. 1541 T/A rs202007160 - CDS AA-STOP[Leu428*] 1591 .. 1591 A/G rs143207798 - CDS Nonsynonymous[Ile445Val] 1617 .. 1617 T/G rs138081362 - CDS Synonymous[Ala453Ala] 1676 .. 1676 C/T rs201811533 - CDS Nonsynonymous[Thr473Ile] 1749 .. 1749 C/T rs140321757 - CDS Synonymous[Asn497Asn] 1767 .. 1767 T/G rs145277303 - CDS Synonymous[Ala503Ala] 1800 .. 1800 T/G rs201113340 - CDS Synonymous[Leu514Leu] 1849 .. 1849 A/C rs151245412 - CDS Nonsynonymous[Asn531His] 1863 .. 1863 A/G rs141045059 - CDS Synonymous[Leu535Leu] 1870 .. 1870 A/C rs147736516 - CDS Nonsynonymous[Ile538Leu] 1898 .. 1898 A/C rs144521437 - CDS Nonsynonymous[Asn547Thr] 1945 .. 1945 C/T rs183678662 - CDS AA-STOP[Arg563*] 1953 .. 1953 G/A rs149269387 - CDS Synonymous[Lys565Lys] 1965 .. 1965 C/T rs140910184 - CDS Synonymous[Pro569Pro] 1989 .. 1989 G/A rs150509891 - CDS Synonymous[Val577Val] 2013 .. 2013 A/G rs138138775 - CDS Synonymous[Ser585Ser] 2034 .. 2034 C/T rs199771667 - 3'UTR 2051 .. 2051 G/A rs143731277 - 3'UTR 2076 .. 2076 G/A rs199945670 - 3'UTR 2169 ^ 2170 -/G rs36093498 - 3'UTR 2175 .. 2175 A/G rs76700603 - 3'UTR 2210 .. 2210 C/T rs147752785 - 3'UTR 2232 .. 2232 C/G rs201381012 - 3'UTR 2256 .. 2256 A/G rs140573935 - 3'UTR  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  No data available Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;