H-InvDB x AHG DB
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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000493469 Accession number: AK298845 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Similar to Pyrroline-5-carboxylate reductase 2; P5C reductase 2; P5CR 2; EC=1.5.1.2;
 
 

Transcript original information
Accession number AK298845.1
CAGE tag ID NA
EST ID NA
Clone Number NT2NE2011421
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ;
Sequence data provider NA
Annotation project NA
Length of cDNA 1625[bp] (No. of exon:8)[A:272 T:291 G:545 C:517]
Devision HUM
Molecular type mRNA
Library origin Cell type teratocarcinoma
Tissue type NA
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) CAGAAG; 
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0200217
Genomic location  G-integra Help Chromosome 1
Location 1q42.12
Position 226074396- 226111978
Strand -
Possible duplicated location(s) NA
Gene structure 8 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene NA
KEGG GENES NA
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000359624
Predicted CDS 169..1248;  359[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.717

Motif information
ORF

length(359),orf(169:1248)
MSVGFIGAGQLAYVLARGFTAAGILSAHKIIASSPEMNLPTVSALRKMGV
NLTRSNKETVKHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVT
ISSVEKAFMALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSEQHP
CQLKDNVCSPGGATIHALHFLESGGFRSLLINAVEASCIRTRGGRQVPGV
GGQHTPAGVRHGAAAAAQQRAGAGRAAALPGAGPQGRAAQARAAVPAQRP
GPGDRRVAARPRRRLQPHLPHRLQAGVRPRERLEGLRRDRGRELLAAAEP
APAAAAATGVGAEGASGPAGVRRPQAGPLCLAGGASRAWGAPAGAAHPGP
WGLWSSGRL*
a.a.
length
InterPro Name
length(105), motif(1:105) 105 IPR016040 NAD(P)-binding domain [Domain]
length(201), motif(1:201) 201 IPR000304 Pyrroline-5-carboxylate reductase [Family]
length(96), motif(3:98) 96 IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal [Domain]
length(87), motif(106:192) 87 IPR029036 Pyrroline-5-carboxylate reductase, dimerisation domain [Domain]
length(86), motif(107:192) 86 IPR029036 Pyrroline-5-carboxylate reductase, dimerisation domain [Domain]
length(86), motif(107:192) 86 IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like [Domain]
length(23), motif(150:172) 23 IPR000304 Pyrroline-5-carboxylate reductase [Family]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000493469
H-Inv cluster ID Locus viewHIX0200217
Accession number AK298845.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help Representative H-Inv IDRepresentative transcript; 
Coding potential  Help Protein coding; 
Definition Similar to Pyrroline-5-carboxylate reductase 2; P5C reductase 2; P5CR 2; EC=1.5.1.2;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (Q96C36)  [Identity/coverage = 99.479%/83.12%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 272283868941531470203915489334167104141696424318669648200682312126946021406692ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol NA
HGNC aliases NA
HGNC name NA
DDBJ NA
UniProt PYCR2
EC number EC 1.5.1.2pyrroline-5-carboxylate reductase; 
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway 00220 :Urea cycle and metabolism of amino groups;  00330 :Arginine and proline metabolism; 
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000359624
No. of interaction 3
Interaction partner(s) HIP000087625HIP000176774HIP000251449
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene NA
KEGG GENES NA
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Human curated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function pyrroline-5-carboxylate reductase activity (GO:0004735); 
Biological process proline biosynthetic process (GO:0006561); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT mitochondria;  cytosol;  nuclear;  Other; 
Target P Not predicted
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
189 280 1bmpA 6e-17 25.0 88/104 g.17.1.2
Related H-InvDB links GTOP GTOP

Evolutionary information  Evola Help Last modified:27-May-2015
Relationship Species Accession number MGI Links
Orthology Equus sp. (Horse) ENSECAT00000011399 G-integraG-integra
Orthology Oryzias sp. (Medaka) ENSORLT00000015269 G-integraG-integra
Orthology Danio sp. (Zebrafish) XM_001918502 G-integraG-integra
Phylogenetic tree [View by ATV]
Neighbor-joining (phb) 
Related H-InvDB links EvolaEvoladN/dS (under constraction); 

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
9 .. 9 G/C rs112979418 - 5'UTR
34 .. 34 A/G rs77157663 + 5'UTR
42 .. 42 C/G/T rs11543045 + 5'UTR
53 .. 53 C/A rs28364597 + 5'UTR
171 .. 171 G/A rs11543043 + CDS Nonsynonymous[Met1Ile]
237 .. 237 C/T rs11543044 + CDS Synonymous[Gly23Gly]
283 .. 283 C/T/A rs146858362 - CDS
303 .. 303 C/G rs144950490 - CDS Synonymous[Leu45Leu]
328 .. 328 C/T rs149894811 - CDS Nonsynonymous[Arg54Cys]
360 .. 360 C/T rs149882706 - CDS Synonymous[Asp64Asp]
361 .. 361 G/A rs150712428 - CDS Nonsynonymous[Val65Ile]
376 .. 376 G/C rs138993893 - CDS Nonsynonymous[Val70Leu]
406 .. 406 G/T rs202095611 - CDS Nonsynonymous[Asp80Tyr]
420 ^ 421 -/C rs35240460 - CDS
442 .. 442 G/A rs200064314 - CDS Nonsynonymous[Val92Met]
456 .. 456 G/A rs148023221 - CDS Synonymous[Ala96Ala]
496 .. 496 G/A rs142577088 - CDS Nonsynonymous[Ala110Thr]
507 .. 507 A/T rs145493247 - CDS Synonymous[Ala113Ala]
544 .. 544 C/T rs199945116 - CDS Nonsynonymous[Arg126Cys]
547 .. 547 C/T rs56362902 - CDS Synonymous[Leu127Leu]
553 .. 553 A/G rs201142342 - CDS Nonsynonymous[Ile129Val]
556 .. 556 C/T rs113324645 - CDS AA-STOP[Gln130*]
561 .. 561 C/T rs55803945 - CDS Synonymous[Leu131Leu]
585 .. 585 T/C rs200949659 - CDS Synonymous[Ala139Ala]
621 .. 621 C/G rs150765933 - CDS Nonsynonymous[Cys151Trp]
622 .. 622 C/T rs201784173 - CDS AA-STOP[Gln152*]
657 .. 657 C/A rs148117976 - CDS Synonymous[Ala163Ala]
699 .. 699 C/T rs138792831 - CDS Synonymous[Arg177Arg]
768 .. 768 T/C rs145431393 - CDS Synonymous[Val200Val]
868 .. 868 C/T rs12753531 - CDS Nonsynonymous[Pro234Ser]
918 .. 918 G/A rs191758097 - CDS Synonymous[Pro250Pro]
1013 .. 1013 G/C rs201293717 - CDS Nonsynonymous[Arg282Pro]
1019 .. 1019 A/G rs200306047 - CDS Nonsynonymous[Glu284Gly]
1160 .. 1160 T/C rs201517157 - CDS Nonsynonymous[Leu331Pro]
1171 .. 1171 G/T rs145906534 - CDS Nonsynonymous[Ala335Ser]
1181 .. 1181 C/T rs201650960 - CDS Nonsynonymous[Ala338Val]
1186 .. 1186 G/A rs41303105 - CDS Nonsynonymous[Gly340Arg]
1202 .. 1202 C/G rs200296829 - CDS Nonsynonymous[Ala345Gly]
1259 .. 1259 C/T rs147571576 - 3'UTR
1268 .. 1268 G/A rs139440539 - 3'UTR
1268 .. 1268 G/A rs75429575 - 3'UTR
1294 .. 1294 G/C rs148675652 - 3'UTR
1317 .. 1317 T/C rs201362049 - 3'UTR
1328 .. 1328 G/A rs146485828 - 3'UTR
1350 .. 1350 C/T rs146082781 - 3'UTR
1386 .. 1386 G/A rs61739581 - 3'UTR
1395 .. 1395 C/T rs150915411 - 3'UTR
1407 .. 1407 C/A rs202201616 - 3'UTR
1413 .. 1413 A/C rs201076564 - 3'UTR
1420 .. 1420 G/A rs146733248 - 3'UTR
1427 .. 1427 G/A rs143958321 - 3'UTR
1432 .. 1432 T/G rs143474754 - 3'UTR
1433 .. 1433 C/G rs200607882 - 3'UTR
1449 .. 1449 C/G rs117876231 - 3'UTR
1458 .. 1458 A/C rs360057 - 3'UTR
1564 .. 1564 T/G rs146506148 - 3'UTR
1581 .. 1581 G/A rs139254695 - 3'UTR
1585 .. 1585 C/G rs35684337 - 3'UTR
1592 .. 1592 T/C rs141038694 - 3'UTR
1599 .. 1599 C/A rs56769658 - 3'UTR
1616 .. 1616 G/A rs200925389 - 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer