H-InvDB - Transcript view HIT000499639

	H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID:	HIT000499639	Accession number:	AK316026	Created date:	26-Mar-2013	Last modified:	27-May-2015
Definition:	Similar to Cyclin-dependent kinase 14.

Transcript original information

Accession number		AK316026.1
CAGE tag ID		NA
EST ID		NA
Clone Number		BRAWH3044108
Experimental resources		NBRC ; HGPD ; Antibody (CLDN12) ; Catalog (CLDN12);
Sequence data provider		NA
Annotation project		NA
Length of cDNA		1944[bp] (No. of exon:14)[A:585 T:504 G:428 C:427]
Devision		HUM
Molecular type		mRNA
Library origin	Cell type	NA
	Tissue type	brain
	Develpmental stage	NA

Sequence quality information

CDS feature	N-truncated
Kozak sequence	NA
PolyA	NA
Vector/adapter sequence	NA
Frame shift	NA
Remaining intron	NA
Splice site acceptor (NAGNAG)	NA
Transcript quality feature	NA
Notes	NA

AGTTGCTGTATGAGCCTGGCCTGGTGCAAACACATTGCTAGAGACATGTT
AAAGAGTTCCAGGTGAATCAAGCCTGAGGGAGACAACAGCAAAACGATAT
GTGTCACAAAGATGTCTACACGGAACTGCCAGGGAATGGACTCAGTGATC
AAACCCCTGGACACAATTCCTGAGGATAAAAAAGTCAGAGTTCAGAGGAC
ACAGAGCACTTTTGACCCATTTGAGAAACCAGCTAATCAAGTAAAGAGGG
TGCATTCTGAGAACAATGCTTGCATTAACTTTAAGACCTCCTCCACTGGC
AAAGAGTCACCTAAAGTTAGGCGGCACTCCAGCCCCAGCTCGCCAACAAG
TCCCAAATTTGGAAAAGCTGACTCATATGAAAAGCTGGAAAAACTAGGGG
AAGGATCTTATGCTACAGTATACAAAGGGAAAAGCAAGGTAAATGGGAAG
TTGGTAGCTCTGAAGGTGATCAGGCTGCAGGAAGAAGAAGGGACACCTTT
CACAGCTATCAGGGAAGCTTCTCTTTTAAAAGGACTAAAACATGCTAACA
TAGTGCTACTTCATGACATCATCCATACCAAGGAGACGCTGACACTTGTG
TTTGAATATGTGCACACTGATTTATGTCAGTACATGGACAAGCACCCTGG
GGGGCTGCATCCAGATAATGTGAAGTTGTTTTTATTTCAGTTGCTGCGAG
GTCTGTCTTACATCCACCAGCGTTATATTTTGCACAGAGACCTGAAACCA
CAGAACCTTCTGATCAGTGACACGGGGGAGTTAAAGCTGGCAGATTTCGG
TCTTGCAAGAGCAAAATCCGTCCCTAGCCACACATACTCCAACGAAGTGG
TTACCTTGTGGTACAGACCTCCAGATGTCCTTCTAGGCTCAACAGAATAT
TCCACCTGCCTTGACATGTGGGGAGTAGGTTGCATCTTTGTTGAAATGAT
CCAAGGAGTTGCTGCTTTTCCAGGAATGAAAGACATTCAGGATCAACTTG
AACGAATATTTCTGGTTCTTGGAACACCAAATGAGGACACATGGCCTGGA
GTTCATTCTTTACCACATTTTAAGCCAGAACGCTTTACCCTGTACAGCTC
TAAAAACCTTAGACAAGCATGGAATAAGCTCAGCTATGTGAACCATGCAG
AGGACCTGGCCTCCAAGCTCCTACAATGTTCCCCAAAGAACAGACTGTCG
GCACAGGCTGCCTTGAGCCACGAGTATTTTAGTGACCTGCCGCCACGGCT
ATGGGAACTCACCGACATGTCTTCTATTTTTACTGTCCCAAATGTGAGAT
TGCAACCAGAAGCTGGAGAAAGCATGCGGGCCTTTGGGAAAAACAATAGT
TATGGCAAAAGTCTATCAAACAGCAAGCACTGACAAGCAGCACATTCTCA
AGAGCACACAGGATTAAGTTGTCATCATTCTGGGAAGAAAAAAAAAACAT
TAATGAAGAGGCCAATAATATGAAGGGAATCATGGATCAGTTTTCTTTCG
CTCCCTGTGGTGGATTTCACTTACAAGAAAATTGAAGCTGGCAAGACCCT
GTTTTCTCTGCAATTTATTTAAAACCTTGCACGCATTTGGATACCTTGTG
ATTTCCAAGAACTACGTGAAGATTAAGCTTTGCTTACTGATACATGGCAT
GTATTCTTTTCAGTCTTTTGTGTTTGATTTTGTTTGATTTCCCTCTGCAG
CACAGCGTCTCTGTAAAGGTTTTTATGCTTTCACCAGCCATGTCTTAAAT
ACATTAAGACAACACATTTGGTGTTCACACTTCTTCAGTAATGTCTGAAC
TTGAAAGCCACAGAGTGGCATAAAACAATGTGTGTTTTCTTTGAGAGCAG
TGCACATTTTGCAACCACTAGGAAGGAAATTTTCTGCTAAAGCAAACCCC
TGTTCTCTGACTTGACAACTTGGCCCCGGACTGTGGGGCCCCAC

Gene structure information

H-Inv cluster ID		HIX0006831
Genomic location	Chromosome	7
	Location	7q21.13
	Position	90339176- 90837012
	Strand	+
Possible duplicated location(s)		NA
Gene structure		14 exon(s)
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:5218;
	KEGG GENES	KEGG GENES(5218);
	GeneCard	CLDN12; *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS; G-integra; cDNA-genome alignment;

Predicted CDS information

HIP ID		HIP000193735
Predicted CDS		67..1383; 438[aa]; Orientation:+1;
Codon Adaptation Index (CAI).		0.737

IKPEGDNSKTICVTKMSTRNCQGMDSVIKPLDTIPEDKKVRVQRTQSTFD
PFEKPANQVKRVHSENNACINFKTSSTGKESPKVRRHSSPSSPTSPKFGK
ADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIRE
ASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPD
NVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAK
SVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAA
FPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQ
AWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTD
MSSIFTVPNVRLQPEAGESMRAFGKNNSYGKSLSNSKH*

Motif information

a.a. length	InterPro	Name
294	IPR011009	Protein kinase-like domain [Domain]
285	IPR002290	Serine/threonine/dual specificity protein kinase, catalytic domain [Domain]
285	IPR000719	Protein kinase domain [Domain]
24	IPR017441	Protein kinase, ATP binding site [Binding_site]
13	IPR008271	Serine/threonine-protein kinase, active site [Active_site]

Gene function information

H-Inv ID		HIT000499639
H-Inv cluster ID		HIX0006831
Accession number		AK316026.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		NO;
Coding potential		Protein coding;
Definition		Similar to Cyclin-dependent kinase 14.
Similarity category		Category: Similar to known protein(Category II).
Similarity category		Similar to known protein (NP_036527) [Identity/coverage = 100.0%/94.9%] to Homo sapiens protein.
Experimental evidence		Protein evidence
PubMed ID		NA
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	CLDN12
	HGNC aliases	NA
	HGNC name	claudin 12
	DDBJ	NA
	UniProt	NA
EC number		EC 2.7.11.22cyclin-dependent kinase;
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		04360 :Axon guidance; 04530 :Tight junction; 04540 :Gap junction; 04660 :T cell receptor signaling pathway;
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000193735
	No. of interaction	NA
	Interaction partner(s)	NA
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	NA
	IntAct	NA
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:5218;
	KEGG GENES	KEGG GENES(5218);
	GeneCard	CLDN12; *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Auto-annotated
Notes		NA
Related H-InvDB links		Gene family; Similarity Search Tool; TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

Gene ontology information

Molecular function	transferase activity, transferring phosphorus-containing groups (GO:0016772); ATP binding (GO:0005524); protein kinase activity (GO:0004672);
Biological process	protein amino acid phosphorylation (GO:0006468);

Subcellular localization information

Last modified:27-May-2015

WoLF PSORT

nuclear; cytosol;

Target P

Other

SOSUI

soluble protein

TMHMM

soluble protein

PTS1

Not targeted

Related H-InvDB links

LIFEdb;

JRE-1.4.0 or later is required.

Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified:27-May-2015

Start	End	PDB_ID	E-value	Identity	Coverage	SCOP_ID
10	377	1nw1A	9e-40	8.1	335/365	d.144.1.8

Related H-InvDB links	GTOP

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel
Location	Variation	dbSNP ID	Strand	CDS/UTR	Translation
2 .. 2	G/A	rs118037123	+	5'UTR
23 .. 23	G/A	rs144186128	+	5'UTR
29 .. 29	A/T	rs80217240	+	5'UTR
76 .. 76	G/T	rs146550540	+	CDS	AA-STOP[Glu4*]
122 .. 122	G/A	rs140679817	+	CDS	Nonsynonymous[Arg19Gln]
156 .. 156	C/T	rs144891494	+	CDS	Synonymous[Pro30Pro]
326 .. 326	A/G	rs187133761	+	CDS	Nonsynonymous[His87Arg]
332 .. 332	G/A	rs138436598	+	CDS	Nonsynonymous[Ser89Asn]
342 .. 342	G/A	rs55722725	+	CDS	Synonymous[Ser92Ser]
416 .. 416	C/T	rs148988868	+	CDS	Nonsynonymous[Thr117Ile]
420 .. 420	A/G	rs145790847	+	CDS	Synonymous[Val118Val]
429 .. 429	G/A	rs200795779	+	CDS	Synonymous[Gly121Gly]
492 .. 492	G/A	rs138497570	+	CDS	Synonymous[Gly142Gly]
501 .. 501	C/T	rs78919227	+	CDS	Synonymous[Phe145Phe]
550 .. 550	A/G	rs146138173	+	CDS	Nonsynonymous[Ile162Val]
588 .. 588	G/A	rs56269509	+	CDS	Synonymous[Thr174Thr]
654 .. 654	G/A/T	rs55664580	+	CDS
657 .. 657	G/A	rs184702498	+	CDS	Synonymous[Leu197Leu]
669 .. 669	T/C	rs141395840	+	CDS	Synonymous[Asn201Asn]
707 .. 707	C/G	rs150860380	+	CDS	Nonsynonymous[Ser214Cys]
756 .. 756	C/T	rs139294759	+	CDS	Synonymous[Asn230Asn]
798 .. 798	C/T	rs202149959	+	CDS	Synonymous[Phe244Phe]
819 .. 819	C/T	rs201386540	+	CDS	Synonymous[Ser251Ser]
842 .. 842	A/G	rs202143669	+	CDS	Nonsynonymous[Asn259Ser]
844 .. 844	G/A	rs144455762	+	CDS	Nonsynonymous[Glu260Lys]
856 .. 856	T/C	rs147407359	+	CDS	Synonymous[Leu264Leu]
895 .. 895	G/C	rs201692399	+	CDS	Nonsynonymous[Glu277Gln]
1002 .. 1002	A/G	rs112955689	+	CDS	Synonymous[Glu312Glu]
1004 .. 1004	G/A	rs139618090	+	CDS	Nonsynonymous[Arg313Gln]
1031 .. 1031	A/G	rs145309096	+	CDS	Nonsynonymous[Asn322Ser]
1047 .. 1047	T/C	rs199729119	+	CDS	Synonymous[Pro327Pro]
1108 .. 1108	C/T	rs34419285	+	CDS	Nonsynonymous[Leu348Phe]
1109 .. 1109	T/G	rs145058405	+	CDS	Nonsynonymous[Leu348Arg]
1136 .. 1136	A/G	rs149042459	+	CDS	Nonsynonymous[Tyr357Cys]
1147 .. 1147	G/A	rs112642464	+	CDS	Nonsynonymous[Ala361Thr]
1152 .. 1152	G/A	rs114347546	+	CDS	Synonymous[Glu362Glu]
1200 .. 1200	G/A	rs151182341	+	CDS	Synonymous[Ser378Ser]
1221 .. 1221	C/T	rs56412135	+	CDS	Synonymous[His385His]
1246 .. 1246	C/G	rs140184613	+	CDS	Nonsynonymous[Arg394Gly]
1249 .. 1249	C/G	rs200612683	+	CDS	Nonsynonymous[Leu395Val]
1327 .. 1327	C/T	rs145303395	+	CDS	Nonsynonymous[Arg421Trp]
1328 .. 1328	G/A	rs74839397	+	CDS	Nonsynonymous[Arg421Gln]
1360 .. 1360	A/C	rs35643773	+	CDS	Nonsynonymous[Ser432Arg]
1363 .. 1363	C/G	rs199515743	+	CDS	Nonsynonymous[Leu433Val]
1373 .. 1373	G/A	rs141334351	+	CDS	Nonsynonymous[Ser436Asn]
1402 .. 1402	G/T	rs192554076	+	3'UTR
1575 .. 1575	C/T	rs12538034	+	3'UTR
1647 .. 1647	G/A	rs186946911	+	3'UTR
1652 .. 1652	T/C	rs117606486	+	3'UTR
1707 .. 1707	G/A	rs79425377	+	3'UTR
1747 .. 1747	A/-	rs57373891	+	3'UTR
1776 .. 1776	C/A	rs192257107	+	3'UTR
1848 .. 1848	C/A	rs57094099	+	3'UTR
1901 .. 1901	T/C	rs144273645	+	3'UTR
1917 .. 1917	A/C	rs182871876	+	3'UTR
1927 .. 1927	C/T	rs187761972	+	3'UTR

Microsatellite (Short Tandem Repeat, STR)
No data available

Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available

Repeat
No data available

Database links	Human-Gene diversity Of Life-style related Diseases(H-GOLD);
Related H-InvDB links	VaryGene; Repeat Mask Viewer;