H-InvDB x AHG DB
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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000558720 Accession number: FJ542284 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Similar to Abelson tyrosine-protein kinase 2 isoform h.
 
 

Transcript original information
Accession number FJ542284.1
CAGE tag ID NA
EST ID NA
Clone Number NA
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (ABL2) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (ABL2);
Sequence data provider NA
Annotation project NA
Length of cDNA 3240[bp] (No. of exon:13)[A:887 T:669 G:851 C:833]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type NA
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) CAGAAG; 
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0001374
Genomic location  G-integra Help Chromosome 1
Location 1q25.2
Position 179076853- 179198532
Strand -
Possible duplicated location(s) NA
Gene structure 13 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:27
KEGG GENES KEGG GENES(27)
GeneCard GeneCardABL2*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000285386
Predicted CDS 1..3240;  1079[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.763
Database links RefSeq NP_001161709
UniProt NA
CCDS CCDS53438

Motif information
ORF

length(1079),orf(1:3240)
MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFT
QHDHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKEN
LLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS
KNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRES
ESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHST
VADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG
EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGV
CTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL
EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIK
WTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEK
GYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISE
EVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATE
NSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKG
GFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGLPEQDRMAMTLPR
NCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLL
PRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAG
VPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDS
QGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPT
EEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSI
SPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADLLSSALTEP
...
a.a.
length
InterPro Name
length(61), motif(107:167) 61 IPR001452 SH3 domain [Domain]
length(86), motif(108:193) 86 IPR001452 SH3 domain [Domain]
length(57), motif(110:166) 57 IPR001452 SH3 domain [Domain]
length(47), motif(113:159) 47 IPR001452 SH3 domain [Domain]
length(120), motif(165:284) 120 IPR000980 SH2 domain [Domain]
length(141), motif(168:308) 141 IPR000980 SH2 domain [Domain]
length(84), motif(171:254) 84 IPR000980 SH2 domain [Domain]
length(15), motif(173:187) 15 IPR000980 SH2 domain [Domain]
length(91), motif(173:263) 91 IPR000980 SH2 domain [Domain]
length(76), motif(173:248) 76 IPR000980 SH2 domain [Domain]
length(11), motif(192:202) 11 IPR000980 SH2 domain [Domain]
length(12), motif(204:215) 12 IPR000980 SH2 domain [Domain]
length(11), motif(216:226) 11 IPR000980 SH2 domain [Domain]
length(15), motif(237:251) 15 IPR000980 SH2 domain [Domain]
length(273), motif(279:551) 273 IPR011009 Protein kinase-like domain [Domain]
length(252), motif(288:539) 252 IPR020635 Tyrosine-protein kinase, catalytic domain [Domain]
length(251), motif(288:538) 251 IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
length(252), motif(288:539) 252 IPR000719 Protein kinase domain [Domain]
length(24), motif(294:317) 24 IPR017441 Protein kinase, ATP binding site [Binding_site]
length(14), motif(361:374) 14 IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
length(19), motif(399:417) 19 IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
length(13), motif(405:417) 13 IPR008266 Tyrosine-protein kinase, active site [Active_site]
length(11), motif(447:457) 11 IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
length(23), motif(466:488) 23 IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
length(23), motif(510:532) 23 IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
length(122), motif(958:1079) 122 IPR015015 F-actin binding [Domain]
length(103), motif(977:1079) 103 IPR015015 F-actin binding [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000558720
H-Inv cluster ID Locus viewHIX0001374
Accession number FJ542284.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help Representative H-Inv IDRepresentative transcript;  Splicing isoformSplicing isoform
Coding potential  Help Protein coding; 
Definition Similar to Abelson tyrosine-protein kinase 2 isoform h.
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (NP_001161710)  [Identity/coverage = 95.841%/100.0%] to Homo sapiens protein.
Experimental evidence Protein evidence
PubMed ID NA
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol ABL2
HGNC aliases "v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)", "v-abl Abelson murine leukemia viral oncogene homolog 2", "c-abl oncogene 2, non-receptor tyrosine kinase"
HGNC name ABL proto-oncogene 2, non-receptor tyrosine kinase
DDBJ NA
UniProt NA
EC number EC 2.7.10.2non-specific protein-tyrosine kinase; 
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway 04020 :Calcium signaling pathway;  04360 :Axon guidance;  04370 :VEGF signaling pathway;  04510 :Focal adhesion;  04520 :Adherens junction;  04530 :Tight junction;  04540 :Gap junction;  04630 :Jak-STAT signaling pathway;  04660 :T cell receptor signaling pathway;  04662 :B cell receptor signaling pathway;  04664 :Fc epsilon RI signaling pathway;  04670 :Leukocyte transendothelial migration;  04730 :Long-term depression;  04810 :Regulation of actin cytoskeleton;  04912 :GnRH signaling pathway;  04920 :Adipocytokine signaling pathway;  05120 :Epithelial cell signaling in Helicobacter pylori infection;  05130 :Pathogenic Escherichia coli infection - EHEC;  05131 :Pathogenic Escherichia coli infection - EPEC; 
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000285386
No. of interaction 16
Interaction partner(s) HIP000008212HIP000021733HIP000022718HIP000026075HIP000030971HIP000033435HIP000041738HIP000046292HIP000066345HIP000075375HIP000083211HIP000083789HIP000085283HIP000102704HIP000106185HIP000157576
BIND NA
DIP NA
MINT NA
HPRD 00282;  00796;  01044;  01267;  01809;  02997;  05813;  12473;  16124; 
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:27
KEGG GENES KEGG GENES(27)
GeneCard GeneCardABL2*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Human curated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function transferase activity, transferring phosphorus-containing groups (GO:0016772);  ATP binding (GO:0005524);  non-membrane spanning protein tyrosine kinase activity (GO:0004715);  protein kinase activity (GO:0004672);  protein-tyrosine kinase activity (GO:0004713);  protein binding (GO:0005515); 
Biological process protein amino acid phosphorylation (GO:0006468); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT nuclear;  cytosol; 
Target P Not predicted
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
110 167 1aboA 2e-16 91.4 58/58 b.34.2.1
200 549 1nw1A 2e-58 8.9 349/365 d.144.1.8
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL liver; 
Probe
information DNAProbeLocator
AceGene NA
Affymetrix
GeneChip
HG-Focus NA
HG-U133 NA
HG-U133A NA
HG-U133A_2 NA
HG-U133B NA
HG-U133_Plus_2 NA
HG-U95 NA
HG-U95A NA
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 NA
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 NA
Whole Human Genome Oligo Microarray:PGID247 NA
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Disease/pathology information  DiseaseInfo Viewer LEGENDA Last modified:27-May-2015
Disease relation Disease name:NA
Related information in OMIM OMIM ID:  164690;  Title: V-ABL ABELSON MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 2
Co-localized orphan diseases NA
Disease related mutation NA
Literature-Extracted GENe-Disease Associations (LEGENDA) LEGENDA Gene name Entrez Gene ID:(27)
Disease Entrez Gene ID:(27)
Substance Entrez Gene ID:(27)
Related H-InvDB links DiseaseInfo ViewerDiseaseInfo ViewerLEGENDALEGENDA

Evolutionary information  Evola Help Last modified:27-May-2015
Relationship Species Accession number MGI Links
Orthology Mus sp. (Mouse) DQ084361 G-integraG-integra
Orthology Equus sp. (Horse) ENSECAT00000006120 G-integraG-integra
Orthology Oryzias sp. (Medaka) ENSORLT00000009306 G-integraG-integra
Orthology Pongo sp. (Orangutan) ENSPPYT00000000554 G-integraG-integra
Orthology Pan sp. (Chimpanzee) ENSPTRT00000058473 G-integraG-integra
Orthology Tetraodon sp. (Tetraodon) GSTENT00028837001 G-integraG-integra
Orthology Takifugu sp. (Fugu) SINFRUT00000176586 G-integraG-integra
Orthology Macaca sp. (Macaque) XM_001115453 G-integraG-integra
Orthology Bos sp. (Cow) XM_001253284 G-integraG-integra
Orthology Monodelphis sp. (Opossum) XM_001365918 G-integraG-integra
Orthology Danio sp. (Zebrafish) XM_001923465 G-integraG-integra
Orthology Gallus sp. (Chicken) XM_422269 G-integraG-integra
Orthology Canis sp. (Dog) XM_537174 G-integraG-integra
Phylogenetic tree [View by ATV]
Neighbor-joining (phb) 
Related H-InvDB links EvolaEvoladN/dS (under constraction); 

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
94 .. 94 G/A rs61821692 - CDS Nonsynonymous[Gly32Ser]
208 .. 208 G/A rs140292380 - CDS Nonsynonymous[Gly70Ser]
233 .. 233 G/A rs55655202 - CDS Nonsynonymous[Arg78His]
239 .. 239 A/G rs140935116 - CDS Nonsynonymous[Tyr80Cys]
292 .. 292 A/G rs201376490 - CDS Nonsynonymous[Lys98Glu]
306 .. 306 C/T rs200064313 - CDS Synonymous[Leu102Leu]
307 .. 307 G/A rs187540054 - CDS Nonsynonymous[Gly103Arg]
336 .. 336 C/T rs200298102 - CDS Synonymous[Phe112Phe]
337 .. 337 G/A rs201168871 - CDS Nonsynonymous[Val113Ile]
380 .. 380 G/A rs147306941 - CDS Nonsynonymous[Ser127Asn]
446 .. 446 G/A rs148596386 - CDS Nonsynonymous[Arg149His]
464 .. 464 G/T rs61821670 - CDS Nonsynonymous[Gly155Val]
509 ^ 510 -/A rs35945588 - CDS
544 .. 544 G/A rs149352120 - CDS Nonsynonymous[Ala182Thr]
650 .. 650 T/C rs112007604 - CDS Nonsynonymous[Val217Ala]
651 .. 651 G/A rs28914528 + CDS Synonymous[Val217Val]
876 .. 876 C/T rs180770623 - CDS Synonymous[His292His]
888 .. 888 C/T rs201235188 - CDS Synonymous[Gly296Gly]
909 .. 909 C/T rs56032037 - CDS Synonymous[Tyr303Tyr]
916 .. 916 G/A rs200847097 - CDS Nonsynonymous[Val306Ile]
939 .. 939 A/G rs28914532 + CDS Synonymous[Thr313Thr]
955 .. 955 T/C rs28914533 + CDS Synonymous[Leu319Leu]
1013 .. 1013 A/G rs192943572 - CDS Nonsynonymous[Glu338Gly]
1032 .. 1032 G/A rs143159520 - CDS Synonymous[Leu344Leu]
1070 .. 1070 T/G rs147552979 - CDS Nonsynonymous[Phe357Cys]
1083 .. 1083 T/G rs150181582 - CDS Synonymous[Thr361Thr]
1086 .. 1086 A/G rs139334603 - CDS Synonymous[Glu362Glu]
1106 .. 1106 T/A rs141559171 - CDS AA-STOP[Leu369*]
1140 .. 1140 G/A rs199688019 - CDS Synonymous[Glu380Glu]
1170 .. 1170 C/T rs201521779 - CDS Synonymous[Ala390Ala]
1297 .. 1297 T/C rs140036159 - CDS Synonymous[Leu433Leu]
1317 .. 1317 T/C rs142746259 - CDS Synonymous[Tyr439Tyr]
1402 .. 1402 G/A rs144729350 - CDS Nonsynonymous[Val468Ile]
1464 .. 1464 T/C rs138565389 - CDS Synonymous[Gly488Gly]
1494 .. 1494 A/C rs2274230 + CDS Synonymous[Leu498Leu]
1631 .. 1631 A/G rs146942033 - CDS Nonsynonymous[His544Arg]
1677 .. 1677 C/T rs151170340 - CDS Synonymous[Ala559Ala]
1820 .. 1820 C/T rs185583542 - CDS Nonsynonymous[Ala607Val]
1822 .. 1822 C/T rs148985886 - CDS Nonsynonymous[Pro608Ser]
1926 .. 1926 A/G rs144233543 - CDS Synonymous[Thr642Thr]
1961 .. 1961 G/C rs199575608 - CDS Nonsynonymous[Ser654Thr]
1990 .. 1990 A/G rs141450341 - CDS Nonsynonymous[Thr664Ala]
1993 .. 1993 C/A rs144066805 - CDS Nonsynonymous[Pro665Thr]
1998 .. 1998 C/T rs138240636 - CDS Synonymous[Pro666Pro]
2049 .. 2049 C/T rs146997813 - CDS Synonymous[Tyr683Tyr]
2057 .. 2057 C/T rs200298510 - CDS Nonsynonymous[Thr686Met]
2058 .. 2058 G/T rs28913887 + CDS Synonymous[Thr686Thr]
2198 .. 2198 A/T rs146696301 - CDS Nonsynonymous[Lys733Ile]
2205 .. 2205 G/A rs138005479 - CDS Synonymous[Glu735Glu]
2316 .. 2316 C/T rs61731092 - CDS Synonymous[Asp772Asp]
2357 .. 2357 A/- rs34839060 - CDS
2404 .. 2404 C/A rs201832781 - CDS Nonsynonymous[Pro802Thr]
2413 .. 2413 G/A rs145907038 - CDS Nonsynonymous[Gly805Arg]
2425 .. 2425 G/T rs140629135 - CDS Nonsynonymous[Gly809Cys]
2467 .. 2467 A/T rs202035355 - CDS Nonsynonymous[Thr823Ser]
2480 .. 2480 A/G rs17277288 - CDS Nonsynonymous[Lys827Arg]
2507 .. 2507 T/G rs201190336 - CDS Nonsynonymous[Leu836Arg]
2527 .. 2527 G/A rs28913889 + CDS Nonsynonymous[Val843Met]
2535 .. 2535 C/T rs35124879 - CDS Synonymous[Leu845Leu]
2540 .. 2540 G/T rs181288208 - CDS Nonsynonymous[Gly847Val]
2575 .. 2575 T/C rs150587634 - CDS Nonsynonymous[Ser859Pro]
2621 .. 2621 G/A rs137859710 - CDS Nonsynonymous[Arg874Gln]
2678 .. 2678 C/G rs28913890 + CDS Nonsynonymous[Pro893Arg]
2679 .. 2679 G/C rs150940806 - CDS Synonymous[Pro893Pro]
2706 .. 2706 G/A rs145868471 - CDS Synonymous[Glu902Glu]
2710 .. 2710 A/G rs140945067 - CDS Nonsynonymous[Thr904Ala]
2756 .. 2756 G/A rs201697670 - CDS Nonsynonymous[Gly919Glu]
2780 .. 2780 T/C rs140016842 - CDS Nonsynonymous[Val927Ala]
2847 .. 2847 C/A rs147901436 - CDS Synonymous[Ser949Ser]
2853 .. 2853 G/T/A rs148651616 - CDS
2870 .. 2870 A/G rs189362240 - CDS Nonsynonymous[Asn957Ser]
2876 .. 2876 C/T rs202244816 - CDS Nonsynonymous[Thr959Ile]
2945 .. 2945 G/A rs28913891 + CDS Nonsynonymous[Ser982Asn]
2974 .. 2974 C/A rs149947908 - CDS Nonsynonymous[Leu992Ile]
2980 .. 2980 T/A rs146190825 - CDS Nonsynonymous[Ser994Thr]
2982 .. 2982 C/T rs184267733 - CDS Synonymous[Ser994Ser]
2984 .. 2984 G/A rs142446654 - CDS Nonsynonymous[Ser995Asn]
2992 .. 2992 A/G rs28913892 + CDS Nonsynonymous[Thr998Ala]
3069 .. 3069 C/T rs201035509 - CDS Synonymous[Cys1023Cys]
3123 .. 3123 A/G rs148342392 - CDS Synonymous[Glu1041Glu]
3149 .. 3149 C/T rs143405311 - CDS Nonsynonymous[Ser1050Phe]
3175 .. 3175 A/G rs138532009 - CDS Nonsynonymous[Thr1059Ala]
3181 .. 3181 C/G rs199707055 - CDS Nonsynonymous[Pro1061Ala]
3195 .. 3195 C/T rs141543536 - CDS Synonymous[Asn1065Asn]
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
Type Start End Strand
L2 157 230 -
MamRTE1 1101 1216 +
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer