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H-Invitational ID: HIT000558721 Accession number: FJ542285 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Abelson tyrosine-protein kinase 2; EC=2.7.10.2; Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; Tyrosine-protein kinase ARG;
 
 

Transcript original information
Accession number FJ542285.1
CAGE tag ID NA
EST ID NA
Clone Number NA
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (ABL2) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (ABL2);
Sequence data provider NA
Annotation project NA
Length of cDNA 3486[bp] (No. of exon:11)[A:939 T:731 G:912 C:904]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type NA
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) CAGAAG; 
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0001374
Genomic location  G-integra Help Chromosome 1
Location 1q25.2
Position 179076853- 179198532
Strand -
Possible duplicated location(s) NA
Gene structure 11 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:27
KEGG GENES KEGG GENES(27)
GeneCard GeneCardABL2*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000285387
Predicted CDS 1..3486;  1161[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.761
Database links RefSeq NP_001161708
UniProt NA
CCDS CCDS53436

Motif information
ORF

length(1161),orf(1:3486)
MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFT
QHEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVAS
GDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKH
SWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYR
INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTV
YGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKE
DTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLD
YLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENH
VVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAF
GVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC
WKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPR
LPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSP
ALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSS
FREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGS
FAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTAS
DDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQ
PEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAI
TEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAP
VLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGD
KDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEG
...
a.a.
length
InterPro Name
length(61), motif(86:146) 61 IPR001452 SH3 domain [Domain]
length(86), motif(87:172) 86 IPR001452 SH3 domain [Domain]
length(57), motif(89:145) 57 IPR001452 SH3 domain [Domain]
length(47), motif(92:138) 47 IPR001452 SH3 domain [Domain]
length(120), motif(144:263) 120 IPR000980 SH2 domain [Domain]
length(141), motif(147:287) 141 IPR000980 SH2 domain [Domain]
length(84), motif(150:233) 84 IPR000980 SH2 domain [Domain]
length(15), motif(152:166) 15 IPR000980 SH2 domain [Domain]
length(91), motif(152:242) 91 IPR000980 SH2 domain [Domain]
length(76), motif(152:227) 76 IPR000980 SH2 domain [Domain]
length(11), motif(171:181) 11 IPR000980 SH2 domain [Domain]
length(12), motif(183:194) 12 IPR000980 SH2 domain [Domain]
length(11), motif(195:205) 11 IPR000980 SH2 domain [Domain]
length(15), motif(216:230) 15 IPR000980 SH2 domain [Domain]
length(273), motif(258:530) 273 IPR011009 Protein kinase-like domain [Domain]
length(252), motif(267:518) 252 IPR020635 Tyrosine-protein kinase, catalytic domain [Domain]
length(251), motif(267:517) 251 IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
length(252), motif(267:518) 252 IPR000719 Protein kinase domain [Domain]
length(24), motif(273:296) 24 IPR017441 Protein kinase, ATP binding site [Binding_site]
length(14), motif(340:353) 14 IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
length(19), motif(378:396) 19 IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
length(13), motif(384:396) 13 IPR008266 Tyrosine-protein kinase, active site [Active_site]
length(11), motif(426:436) 11 IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
length(23), motif(445:467) 23 IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
length(23), motif(489:511) 23 IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain [Domain]
length(122), motif(1040:1161) 122 IPR015015 F-actin binding [Domain]
length(103), motif(1059:1161) 103 IPR015015 F-actin binding [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000558721
H-Inv cluster ID Locus viewHIX0001374
Accession number FJ542285.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO;  Splicing isoformSplicing isoform
Coding potential  Help Protein coding; 
Definition Abelson tyrosine-protein kinase 2; EC=2.7.10.2; Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; Tyrosine-protein kinase ARG;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (P42684)  [Identity/coverage = 98.223%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 219857137872601274829012775773147020391472917915489334157357351588609816678104167104141696424317306540173448461752533217974005181822991866964818691976188107621894567419369195196903322006823120841568214066922141734322297987ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol ABL2
HGNC aliases "v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)", "v-abl Abelson murine leukemia viral oncogene homolog 2", "c-abl oncogene 2, non-receptor tyrosine kinase"
HGNC name ABL proto-oncogene 2, non-receptor tyrosine kinase
DDBJ NA
UniProt ABL2
EC number EC 2.7.10.2non-specific protein-tyrosine kinase; 
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway 04020 :Calcium signaling pathway;  04360 :Axon guidance;  04370 :VEGF signaling pathway;  04510 :Focal adhesion;  04520 :Adherens junction;  04530 :Tight junction;  04540 :Gap junction;  04630 :Jak-STAT signaling pathway;  04660 :T cell receptor signaling pathway;  04662 :B cell receptor signaling pathway;  04664 :Fc epsilon RI signaling pathway;  04670 :Leukocyte transendothelial migration;  04730 :Long-term depression;  04810 :Regulation of actin cytoskeleton;  04912 :GnRH signaling pathway;  04920 :Adipocytokine signaling pathway;  05120 :Epithelial cell signaling in Helicobacter pylori infection;  05130 :Pathogenic Escherichia coli infection - EHEC;  05131 :Pathogenic Escherichia coli infection - EPEC; 
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000285387
No. of interaction 10
Interaction partner(s) HIP000028444HIP000028444HIP000037309HIP000037309HIP000054177HIP000059105HIP000087997HIP000104670HIP000125446HIP000192588
BIND 177272;  258877;  258878;  58089;  58130; 
DIP 131587E;  131654E;  131745E;  131763E;  131975E;  132216E;  132385E;  288E;  58813E; 
MINT MINT-59458;  MINT-59459;  MINT-59461;  MINT-59462;  MINT-7041692;  MINT-74432;  MINT-74433;  MINT-74434;  MINT-74435;  MINT-74436;  MINT-74437;  MINT-74438;  MINT-74439;  MINT-74440;  MINT-74441;  MINT-74442;  MINT-74443;  MINT-74444;  MINT-74445;  MINT-74446;  MINT-74447;  MINT-74448;  MINT-74449;  MINT-74450;  MINT-74451;  MINT-74452;  MINT-74453;  MINT-74454;  MINT-74455;  MINT-74456;  MINT-74457;  MINT-74458;  MINT-7908314;  MINT-7908442;  MINT-8034736;  MINT-8110899;  MINT-8111655;  MINT-8112351;  MINT-8112867; 
HPRD 00579;  00796;  01281;  01398;  01809;  01819;  01820;  02533;  02740;  02767;  05142;  05813;  07338;  09352;  14381; 
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:27
KEGG GENES KEGG GENES(27)
GeneCard GeneCardABL2*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function transferase activity, transferring phosphorus-containing groups (GO:0016772);  ATP binding (GO:0005524);  non-membrane spanning protein tyrosine kinase activity (GO:0004715);  protein kinase activity (GO:0004672);  protein-tyrosine kinase activity (GO:0004713);  protein binding (GO:0005515); 
Biological process protein amino acid phosphorylation (GO:0006468); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT nuclear;  cytosol; 
Target P Not predicted
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
89 146 1aboA 2e-16 91.4 58/58 b.34.2.1
179 528 1nw1A 2e-59 8.9 349/365 d.144.1.8
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL liver; 
Probe
information DNAProbeLocator
AceGene NA
Affymetrix
GeneChip
HG-Focus NA
HG-U133 NA
HG-U133A NA
HG-U133A_2 NA
HG-U133B NA
HG-U133_Plus_2 NA
HG-U95 NA
HG-U95A NA
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 NA
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 NA
Whole Human Genome Oligo Microarray:PGID247 NA
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Disease/pathology information  DiseaseInfo Viewer LEGENDA Last modified:27-May-2015
Disease relation Disease name:NA
Related information in OMIM OMIM ID:  164690;  Title: V-ABL ABELSON MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 2
Co-localized orphan diseases NA
Disease related mutation NA
Literature-Extracted GENe-Disease Associations (LEGENDA) LEGENDA Gene name Entrez Gene ID:(27)
Disease Entrez Gene ID:(27)
Substance Entrez Gene ID:(27)
Related H-InvDB links DiseaseInfo ViewerDiseaseInfo ViewerLEGENDALEGENDA

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
94 .. 94 G/A rs61821692 - CDS Nonsynonymous[Gly32Ser]
170 .. 170 G/A rs55655202 - CDS Nonsynonymous[Arg57His]
176 .. 176 A/G rs140935116 - CDS Nonsynonymous[Tyr59Cys]
229 .. 229 A/G rs201376490 - CDS Nonsynonymous[Lys77Glu]
243 .. 243 C/T rs200064313 - CDS Synonymous[Leu81Leu]
244 .. 244 G/A rs187540054 - CDS Nonsynonymous[Gly82Arg]
273 .. 273 C/T rs200298102 - CDS Synonymous[Phe91Phe]
274 .. 274 G/A rs201168871 - CDS Nonsynonymous[Val92Ile]
317 .. 317 G/A rs147306941 - CDS Nonsynonymous[Ser106Asn]
383 .. 383 G/A rs148596386 - CDS Nonsynonymous[Arg128His]
401 .. 401 G/T rs61821670 - CDS Nonsynonymous[Gly134Val]
446 ^ 447 -/A rs35945588 - CDS
481 .. 481 G/A rs149352120 - CDS Nonsynonymous[Ala161Thr]
587 .. 587 T/C rs112007604 - CDS Nonsynonymous[Val196Ala]
588 .. 588 G/A rs28914528 + CDS Synonymous[Val196Val]
813 .. 813 C/T rs180770623 - CDS Synonymous[His271His]
825 .. 825 C/T rs201235188 - CDS Synonymous[Gly275Gly]
846 .. 846 C/T rs56032037 - CDS Synonymous[Tyr282Tyr]
853 .. 853 G/A rs200847097 - CDS Nonsynonymous[Val285Ile]
876 .. 876 A/G rs28914532 + CDS Synonymous[Thr292Thr]
892 .. 892 T/C rs28914533 + CDS Synonymous[Leu298Leu]
950 .. 950 A/G rs192943572 - CDS Nonsynonymous[Glu317Gly]
969 .. 969 G/A rs143159520 - CDS Synonymous[Leu323Leu]
1007 .. 1007 T/G rs147552979 - CDS Nonsynonymous[Phe336Cys]
1020 .. 1020 T/G rs150181582 - CDS Synonymous[Thr340Thr]
1023 .. 1023 A/G rs139334603 - CDS Synonymous[Glu341Glu]
1043 .. 1043 T/A rs141559171 - CDS AA-STOP[Leu348*]
1077 .. 1077 G/A rs199688019 - CDS Synonymous[Glu359Glu]
1107 .. 1107 C/T rs201521779 - CDS Synonymous[Ala369Ala]
1234 .. 1234 T/C rs140036159 - CDS Synonymous[Leu412Leu]
1254 .. 1254 T/C rs142746259 - CDS Synonymous[Tyr418Tyr]
1339 .. 1339 G/A rs144729350 - CDS Nonsynonymous[Val447Ile]
1401 .. 1401 T/C rs138565389 - CDS Synonymous[Gly467Gly]
1431 .. 1431 A/C rs2274230 + CDS Synonymous[Leu477Leu]
1568 .. 1568 A/G rs146942033 - CDS Nonsynonymous[His523Arg]
1614 .. 1614 C/T rs151170340 - CDS Synonymous[Ala538Ala]
1757 .. 1757 C/T rs185583542 - CDS Nonsynonymous[Ala586Val]
1759 .. 1759 C/T rs148985886 - CDS Nonsynonymous[Pro587Ser]
1863 .. 1863 A/G rs144233543 - CDS Synonymous[Thr621Thr]
1898 .. 1898 G/C rs199575608 - CDS Nonsynonymous[Ser633Thr]
1927 .. 1927 A/G rs141450341 - CDS Nonsynonymous[Thr643Ala]
1930 .. 1930 C/A rs144066805 - CDS Nonsynonymous[Pro644Thr]
1935 .. 1935 C/T rs138240636 - CDS Synonymous[Pro645Pro]
1986 .. 1986 C/T rs146997813 - CDS Synonymous[Tyr662Tyr]
1994 .. 1994 C/T rs200298510 - CDS Nonsynonymous[Thr665Met]
1995 .. 1995 G/T rs28913887 + CDS Synonymous[Thr665Thr]
2024 .. 2024 A/G rs150953979 - CDS Nonsynonymous[Gln675Arg]
2054 .. 2054 C/A rs143839622 - CDS Nonsynonymous[Ala685Asp]
2096 ^ 2097 -/G rs67764190 - CDS
2127 .. 2127 C/T rs28913888 + CDS Synonymous[Asp709Asp]
2130 .. 2130 C/T rs144460998 - CDS Synonymous[Asp710Asp]
2131 .. 2131 G/A rs148512062 - CDS Nonsynonymous[Gly711Ser]
2139 .. 2139 G/T rs139820193 - CDS Synonymous[Gly713Gly]
2173 .. 2173 T/G rs78418476 - CDS Nonsynonymous[Ser725Ala]
2175 .. 2175 T/C rs147272038 - CDS Synonymous[Ser725Ser]
2201 .. 2201 G/A rs147435995 - CDS Nonsynonymous[Arg734His]
2211 .. 2211 A/G rs202245355 - CDS Synonymous[Lys737Lys]
2218 .. 2218 C/T rs140267087 - CDS Synonymous[Leu740Leu]
2287 .. 2287 A/T rs55892721 - CDS Nonsynonymous[Thr763Ser]
2444 .. 2444 A/T rs146696301 - CDS Nonsynonymous[Lys815Ile]
2451 .. 2451 G/A rs138005479 - CDS Synonymous[Glu817Glu]
2562 .. 2562 C/T rs61731092 - CDS Synonymous[Asp854Asp]
2603 .. 2603 A/- rs34839060 - CDS
2650 .. 2650 C/A rs201832781 - CDS Nonsynonymous[Pro884Thr]
2659 .. 2659 G/A rs145907038 - CDS Nonsynonymous[Gly887Arg]
2671 .. 2671 G/T rs140629135 - CDS Nonsynonymous[Gly891Cys]
2713 .. 2713 A/T rs202035355 - CDS Nonsynonymous[Thr905Ser]
2726 .. 2726 A/G rs17277288 - CDS Nonsynonymous[Lys909Arg]
2753 .. 2753 T/G rs201190336 - CDS Nonsynonymous[Leu918Arg]
2773 .. 2773 G/A rs28913889 + CDS Nonsynonymous[Val925Met]
2781 .. 2781 C/T rs35124879 - CDS Synonymous[Leu927Leu]
2786 .. 2786 G/T rs181288208 - CDS Nonsynonymous[Gly929Val]
2821 .. 2821 T/C rs150587634 - CDS Nonsynonymous[Ser941Pro]
2867 .. 2867 G/A rs137859710 - CDS Nonsynonymous[Arg956Gln]
2924 .. 2924 C/G rs28913890 + CDS Nonsynonymous[Pro975Arg]
2925 .. 2925 G/C rs150940806 - CDS Synonymous[Pro975Pro]
2952 .. 2952 G/A rs145868471 - CDS Synonymous[Glu984Glu]
2956 .. 2956 A/G rs140945067 - CDS Nonsynonymous[Thr986Ala]
3002 .. 3002 G/A rs201697670 - CDS Nonsynonymous[Gly1001Glu]
3026 .. 3026 T/C rs140016842 - CDS Nonsynonymous[Val1009Ala]
3093 .. 3093 C/A rs147901436 - CDS Synonymous[Ser1031Ser]
3099 .. 3099 G/T/A rs148651616 - CDS
3116 .. 3116 A/G rs189362240 - CDS Nonsynonymous[Asn1039Ser]
3122 .. 3122 C/T rs202244816 - CDS Nonsynonymous[Thr1041Ile]
3191 .. 3191 G/A rs28913891 + CDS Nonsynonymous[Ser1064Asn]
3220 .. 3220 C/A rs149947908 - CDS Nonsynonymous[Leu1074Ile]
3226 .. 3226 T/A rs146190825 - CDS Nonsynonymous[Ser1076Thr]
3228 .. 3228 C/T rs184267733 - CDS Synonymous[Ser1076Ser]
3230 .. 3230 G/A rs142446654 - CDS Nonsynonymous[Ser1077Asn]
3238 .. 3238 A/G rs28913892 + CDS Nonsynonymous[Thr1080Ala]
3315 .. 3315 C/T rs201035509 - CDS Synonymous[Cys1105Cys]
3369 .. 3369 A/G rs148342392 - CDS Synonymous[Glu1123Glu]
3395 .. 3395 C/T rs143405311 - CDS Nonsynonymous[Ser1132Phe]
3421 .. 3421 A/G rs138532009 - CDS Nonsynonymous[Thr1141Ala]
3427 .. 3427 C/G rs199707055 - CDS Nonsynonymous[Pro1143Ala]
3441 .. 3441 C/T rs141543536 - CDS Synonymous[Asn1147Asn]
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
Type Start End Strand
MamRTE1 1038 1153 +
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer