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Accession No.: BC053878
Definition: Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

  Auto-functional annotation Mapping cDNA Predicted ORF Predicted motif
H-Inv ID HIT000054010
Definition Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).
Similarity category III III IV V NA
DataSource P43403
Species Homo sapiens (Human).
Identity 100 %
Coverage 100 %
Evidence FASTY Similar
CDS 184..2043
Amino acid length [amino acids] 619
Codon Adaptation Index(CAI). 0.835


Corresponding HIX HIX0002292
Chromosome No. 2
Location on Chromosome 97696461-97722757
Chromosomal band 2q11.2
Strand forward


DNA Databank accession number BC053878.1
Definition in DNA Databanks Homo sapiens zeta-chain (TCR) associated protein kinase 70kDa, mRNA (cDNA clone MGC:61743 IMAGE:5757161), complete cds.
Length of cDNA 2468 [bp]
Species Homo sapiens
Clone No MGC:61743 IMAGE:5757161
Cell type NA
Tissue type Blood, adult leukocytes
Developmental stage NA
EC number NA
Gene name ZAP70
Sequence(2468 bp)


Predicted ORF
Translation(619 aa) : Start 184 End 2043 Frame +1


Start End a.a.length InterPro Name Go
1195 1983 263 IPR000719 Protein kinase, core [Domain] Molecular Function: protein kinase activity (GO:0004672), Molecular Function: ATP binding (GO:0005524), Biological Process: protein amino acid phosphorylation (GO:0006468)
1213 1290 26 IPR000719 Protein kinase, core [Domain] Molecular Function: protein kinase activity (GO:0004672), Molecular Function: ATP binding (GO:0005524), Biological Process: protein amino acid phosphorylation (GO:0006468)
1213 1941 243 IPR000719 Protein kinase, core [Domain] Molecular Function: protein kinase activity (GO:0004672), Molecular Function: ATP binding (GO:0005524), Biological Process: protein amino acid phosphorylation (GO:0006468)
190 516 109 IPR000980 SH2 motif [Domain] Biological Process: intracellular signaling cascade (GO:0007242)
205 462 86 IPR000980 SH2 motif [Domain] Biological Process: intracellular signaling cascade (GO:0007242)
211 444 78 IPR000980 SH2 motif [Domain] Biological Process: intracellular signaling cascade (GO:0007242)
211 489 93 IPR000980 SH2 motif [Domain] Biological Process: intracellular signaling cascade (GO:0007242)
214 498 95 IPR000980 SH2 motif [Domain] Biological Process: intracellular signaling cascade (GO:0007242)
655 951 99 IPR000980 SH2 motif [Domain] Biological Process: intracellular signaling cascade (GO:0007242)
664 918 85 IPR000980 SH2 motif [Domain] Biological Process: intracellular signaling cascade (GO:0007242)
670 714 15 IPR000980 SH2 motif [Domain] Biological Process: intracellular signaling cascade (GO:0007242)
670 900 77 IPR000980 SH2 motif [Domain] Biological Process: intracellular signaling cascade (GO:0007242)
670 945 92 IPR000980 SH2 motif [Domain] Biological Process: intracellular signaling cascade (GO:0007242)
670 948 93 IPR000980 SH2 motif [Domain] Biological Process: intracellular signaling cascade (GO:0007242)
733 765 11 IPR000980 SH2 motif [Domain] Biological Process: intracellular signaling cascade (GO:0007242)
766 801 12 IPR000980 SH2 motif [Domain] Biological Process: intracellular signaling cascade (GO:0007242)
802 834 11 IPR000980 SH2 motif [Domain] Biological Process: intracellular signaling cascade (GO:0007242)
865 909 15 IPR000980 SH2 motif [Domain] Biological Process: intracellular signaling cascade (GO:0007242)
1195 1962 256 IPR001245 Tyrosine protein kinase [Domain] Molecular Function: protein-tyrosine kinase activity (GO:0004713), Molecular Function: ATP binding (GO:0005524), Biological Process: protein amino acid phosphorylation (GO:0006468)
1195 1962 256 IPR001245 Tyrosine protein kinase [Domain] Molecular Function: protein-tyrosine kinase activity (GO:0004713), Molecular Function: ATP binding (GO:0005524), Biological Process: protein amino acid phosphorylation (GO:0006468)
1423 1464 14 IPR001245 Tyrosine protein kinase [Domain] Molecular Function: protein-tyrosine kinase activity (GO:0004713), Molecular Function: ATP binding (GO:0005524), Biological Process: protein amino acid phosphorylation (GO:0006468)
1534 1590 19 IPR001245 Tyrosine protein kinase [Domain] Molecular Function: protein-tyrosine kinase activity (GO:0004713), Molecular Function: ATP binding (GO:0005524), Biological Process: protein amino acid phosphorylation (GO:0006468)
1684 1716 11 IPR001245 Tyrosine protein kinase [Domain] Molecular Function: protein-tyrosine kinase activity (GO:0004713), Molecular Function: ATP binding (GO:0005524), Biological Process: protein amino acid phosphorylation (GO:0006468)
1741 1809 23 IPR001245 Tyrosine protein kinase [Domain] Molecular Function: protein-tyrosine kinase activity (GO:0004713), Molecular Function: ATP binding (GO:0005524), Biological Process: protein amino acid phosphorylation (GO:0006468)
1873 1941 23 IPR001245 Tyrosine protein kinase [Domain] Molecular Function: protein-tyrosine kinase activity (GO:0004713), Molecular Function: ATP binding (GO:0005524), Biological Process: protein amino acid phosphorylation (GO:0006468)
1195 1974 260 IPR002290 Serine/threonine protein kinase [Domain] Molecular Function: protein serine/threonine kinase activity (GO:0004674), Molecular Function: ATP binding (GO:0005524), Biological Process: protein amino acid phosphorylation (GO:0006468)
1552 1590 13 IPR008266 Tyrosine protein kinase, active site [Active_site] Molecular Function: protein-tyrosine kinase activity (GO:0004713), Molecular Function: ATP binding (GO:0005524), Biological Process: protein amino acid phosphorylation (GO:0006468)
1111 1998 296 IPR011009 Protein kinase-like [Domain] NA
184 1989 602 IPR012234 Tyrosine protein kinase, SYK/ZAP-70 [Family] Molecular Function: non-membrane spanning protein tyrosine kinase activity (GO:0004715), Molecular Function: ATP binding (GO:0005524), Cellular Component: cytoplasm (GO:0005737), Biological Process: signal transduction (GO:0007165)



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